Mutational studies of human DNA polymerase alpha. Identification of residues critical for deoxynucleotide binding and misinsertion fidelity of DNA synthesis.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

An attempt to unify the structure of polymerases

1990 • 640 citations

EUKARYOTIC DNA POLYMERASES

1991 • 493 citations

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

1988 • 405 citations

A third essential DNA polymerase in S. cerevisiae

1990 • 360 citations

Proteins : structures and molecular principles

1983 • 357 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

1990 • 261 citations

Preparation and preliminary characterization of monoclonal antibodies against human DNA polymerase alpha.

1982 • 257 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.

1989 • 231 citations

Human DNA polymerase α: predicted functional domains and relationships with viral DNA polymerases

1989 • 201 citations

DNA replication fidelity.

1992 • 191 citations

An in vitro transversion by a mutationally altered T4-induced DNA polymerase

1968 • 190 citations

Elementary steps in the DNA polymerase I reaction pathway

1983 • 179 citations

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.

1990 • 169 citations

DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.

1988 • 168 citations

DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.

1990 • 129 citations

A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

1991 • 124 citations

Fidelity of mammalian DNA replication and replicative DNA polymerases

1991 • 119 citations

Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA.

1992 • 105 citations

Mutational analysis of the human DNA polymerase alpha. The most conserved region in alpha-like DNA polymerases is involved in metal-specific catalysis

1993 • 99 citations

Butylphenyl dGTP: a selective and potent inhibitor of mammalian DNA polymerase alpha

1984 • 94 citations

Human DNA polymerase α catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus

1990 • 88 citations

Primary structure of the catalytic subunit of calf thymus DNA polymerase .delta.: sequence similarities with other DNA polymerases

1991 • 82 citations

Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini.

1992 • 81 citations

Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment).

1992 • 73 citations

Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterization.

1991 • 71 citations

Kinetic Analysis of Base Substitution Mutagenesis by Transient Misalignment of DNA and by Miscoding

1989 • 70 citations

Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.

1991 • 65 citations

The POL1 gene from the fission yeast, Schizosaccharomyces pombe, shows conserved amino acid blocks specific for eukaryotic DNA polymerases alpha

1991 • 57 citations

On the fidelity of DNA replication. Studies with human placenta DNA polymerases.

1979 • 54 citations

Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis

1993 • 53 citations

A DNA polymerase alpha pause site is a hot spot for nucleotide misinsertion.

1992 • 47 citations

Cell cycle expression of two replicative DNA polymerases alpha and delta from Schizosaccharomyces pombe.

1993 • 42 citations

DNA replication fidelity: kinetics and thermodynamics

1988 • 37 citations

Fidelity of fractionated deoxyribonucleic acid polymerases from human placenta

1980 • 36 citations

Mutational studies of human DNA polymerase alpha. Serine 867 in the second most conserved region among alpha-like DNA polymerases is involved in primer binding and mispair primer extension.

1993 • 33 citations