A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

Isolation, Characterization, and Expression in Escherichia coli of the DNA Polymerase Gene from Thermus aquaticus

1989 • 370 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

Selective Elimination of the Exonuclease Activity of the Deoxyribonucleic Acid Polymerase from Escherichia coli B by Limited Proteolysis

1970 • 326 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Deoxyribonucleic Acid Polymerase: Two Distinct Enzymes in One Polypeptide

1972 • 215 citations

An active fragment of DNA polymerase produced by proteolytic cleavage

1969 • 190 citations

Elementary steps in the DNA polymerase I reaction pathway

1983 • 179 citations

Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.

1983 • 168 citations

[61] Rapid kinetic analysis of mechanochemical adenosinetriphosphatases

1986 • 151 citations

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity.

1986 • 148 citations

High-resolution structure of a DNA helix containing mismatched base pairs

1985 • 133 citations

Structural Studies of DNA Fragments: The G·T Wobble Base Pair in A, B and Z DNA; The G·A Base Pair in B-DNA

1985 • 130 citations

A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics

1988 • 130 citations

Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α

1989 • 129 citations

Molecular mechanisms of manganese mutagenesis.

1984 • 96 citations

Characterization of the polA Gene of Streptococcus pneumoniae and Comparison of the DNA Polymerase I It Encodes to Homologous Enzymes from Escherichia coli and Phage T7

1989 • 78 citations

Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts

1990 • 60 citations

T5 DNA polymerase: structural--functional relationships to other DNA polymerases.

1989 • 58 citations

Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions.

1986 • 55 citations

Kinetics of base misinsertion by DNA polymerase I of Escherichia coli

1983 • 44 citations