Thyroid Hormone Control of Brain and Motor Development: Molecular, Neuroanatomical, and Behavioral Studies

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Thomas, Springfield, Illinois

1965 • 2,935 citations

The Metabolic Basis of Inherited Diseases

1972 • 1,762 citations

Submitted Publication

2022 • 1,326 citations

Antecedents of Cerebral Palsy

1986 • 938 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Cytoskeletal dynamics and nerve growth

1988 • 855 citations

Maternal-Fetal Transfer of Thyroxine in Congenital Hypothyroidism Due to a Total Organification Defect or Thyroid Agenesis

1989 • 783 citations

ULTRASTRUCTURE AND FUNCTION OF GROWTH CONES AND AXONS OF CULTURED NERVE CELLS

1971 • 769 citations

Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology

1988 • 599 citations

The expression and posttranslational modification of a neuron‐specific β‐tubulin isotype during chick embryogenesis

1990 • 589 citations

A membrane phosphoprotein associated with neural development, axonal regeneration, phospholipid metabolism, and synaptic plasticity

1987 • 543 citations

Thyroid Development and Disorders of Thyroid Function in the Newborn

1981 • 528 citations

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

1985 • 506 citations

The Postnatal Development of the Human Cerebral Cortex

1960 • 480 citations

Structure and Utilization of Tubulin Isotypes

1988 • 474 citations

Normal and abnormal development of the human nervous system

1975 • 405 citations

Normal and abnormal development of the human nervous system

1976 • 403 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Effects of Maternal Hypothyroidism on the Weight and Thyroid Hormone Content of Rat Embryonic Tissues, before and after Onset of Fetal Thyroid Function*

1985 • 366 citations

The pyramidal tract

1990 • 349 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Neuronal Cytomechanics: The Actin-Based Motility of Growth Cones

1988 • 331 citations

Five mouse tubulin isotypes and their regulated expression during development.

1985 • 323 citations

Regulation of gene expression by thyroid hormone.

1988 • 317 citations

Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats.

1990 • 298 citations

Axonal transport of the cytoplasmic matrix.

1984 • 295 citations

Growth and target finding by axons of the corticospinal tract in prenatal and postnatal rats

1982 • 291 citations

The development of the cerebral cortex in the embryonic mouse: An electron microscopic serial section analysis

1978 • 282 citations

Prenatal and early postnatal ontogenesis of the human motor cortex: A Golgi study. I. The sequential development of the cortical layers

1970 • 280 citations

Intrapartum Asphyxia and Cerebral Palsy

1988 • 278 citations

Growth of the corticospinal tract and the development of placing reactions in the postnatal rat

1977 • 276 citations

Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype.

1988 • 271 citations

Mechanisms of Fast and Slow Axonal Transport

1991 • 269 citations

ONTOGENESIS OF THE NUCLEAR 3,5,3′-TRIIODOTHYRONINE RECEPTOR IN THE HUMAN FETAL BRAIN

1984 • 268 citations

Intrinsic determinants of neuronal form and function

1989 • 264 citations

Studies in developmental neurobiology

1983 • 263 citations

Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary.

1989 • 251 citations

Development of Projection and Local Circuit Neurons in Neocortex

1988 • 249 citations

Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system.

1984 • 238 citations

Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers.

1985 • 228 citations

Hormonal Effects on Ontogeny of Swimming Ability in the Rat: Assessment of Central Nervous System Development

1970 • 227 citations

Pediatric Clinics of North America

2020 • 226 citations

Ontogeny of spatial navigation behaviors in the rat: Dissociation of "proximal"- and "distal"-cue-based behaviors.

1987 • 226 citations

Ontogeny of spatial navigation behaviors in the rat: Dissociation of "proximal"- and "distal"-cue-based behaviors.

1987 • 223 citations

Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons

1989 • 217 citations

Common and distinct tubulin binding sites for microtubule-associated proteins.

1986 • 216 citations

Antecedents of Cerebral Palsy

1985 • 214 citations

Two Drosophila beta tubulin isoforms are not functionally equivalent.

1990 • 212 citations

Plasma Thyroxine and Triiodothyronine Levels in Spontaneously Metamorphosing Rana catesbeiana Tadpoles and in Adult Anuran Amphibia*

1978 • 210 citations

Isotypes of alpha-tubulin are differentially regulated during neuronal maturation.

1987 • 207 citations

Maturation of pyramidal cell form in relation to developing afferent and efferent connections of rat somatic sensory cortex

1979 • 206 citations

Regulation of tubulin and actin mRNA production in rat brain: expression of a new beta-tubulin mRNA with development.

1983 • 205 citations

THE CEREBRAL CORTEX OF NORMAL AND HYPOTHYROID RATS

1955 • 202 citations

Intellectual outcome in children with fetal hypothyroidism

1987 • 197 citations

Association of microtubule-associated protein 2 (MAP 2) with microtubules and intermediate filaments in cultured brain cells.

1983 • 193 citations

Histology and histopathology of the nervous system

1982 • 188 citations

Correlation of axonal regeneration and slow component B in two branches of a single axon

1983 • 178 citations

Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin

1989 • 174 citations

Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine

1985 • 173 citations

In situ localization of microtubule-associated protein mRNA in the developing and adult rat brain

1989 • 165 citations

Inherited Primary Hypothyroidism in Mice

1981 • 161 citations

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells.

1988 • 160 citations

Determinants of cell shape and orientation: A comparative Golgi analysis of cell‐axon interrelationships in the developing neocortex of normal and reeler mice

1979 • 159 citations

Thyroxine-dependent modulation of actin polymerization in cultured astrocytes. A novel, extranuclear action of thyroid hormone.

1990 • 155 citations

Differential distribution of beta-tubulin isotypes in cerebellum.

1988 • 154 citations

Thyroid hormone and development of the rat hippocampus: Morphological alterations in granule and pyramidal cells

1986 • 152 citations

NEUROLOGICAL SIGNS IN CONGENITAL IODINE‐DEFICIENCY DISORDER (ENDEMIC CRETINISM)

1985 • 150 citations

Effect of prenatal exposure to alcohol on the distribution and time of origin of corticospinal neurons in the rat

1987 • 147 citations

Altered slow axonal transport and regeneration in a myelin-deficient mutant mouse: the trembler as an in vivo model for Schwann cell-axon interactions

1990 • 140 citations

Axonal transport of actin: Slow component b is the principal source of actin for the axon

1979 • 137 citations

Scientific basis of clinical neurology

1985 • 137 citations

Localization of the tubulin binding site for tau protein

1985 • 129 citations

Early Ontogenesis of the Human Cerebral Cortex

1988 • 128 citations

POLYNEUROPATHY ASSOCIATED WITH HYPOTHYROIDISM

1970 • 123 citations

Differential interaction of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with microtubule-associated proteins.

1988 • 120 citations

Neurological abnormalities in patients treated for hypothyroidism from early life.

1978 • 120 citations

Methemoglobinemia Provoked by Malarial Chemoprophylaxis in Vietnam

1968 • 119 citations

G Proteins and Regulation of Adenylyl Cyclase

1989 • 114 citations

Early Treatment of Congenital Hypothyroidism

1989 • 113 citations

MATERNAL THYROID HORMONE LEVELS IN PREGNANCY AND THE SUBSEQUENT COGNITIVE AND MOTOR PERFORMANCE OF THE CHILDREN

1984 • 113 citations

A nonsense mutation causes hereditary goitre in the Afrikander cattle and unmasks alternative splicing of thyroglobulin transcripts.

1987 • 111 citations

Complex regulation and functional versatility of mammalian alpha- and beta-tubulin isotypes during the differentiation of testis and muscle cells.

1988 • 110 citations

Thyroid Hormones and the Developing Brain

1986 • 109 citations

Congenital Hypothyroidism

1984 • 107 citations

Triiodothyronine Stimulation of Oligodendroglial Differentiation and Myelination

1985 • 106 citations

Control of Thyroperoxidase and Thyroglobulin Transcription by cAMP: Evidence for Distinct Regulatory Mechanisms

1989 • 105 citations

Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation

1989 • 103 citations

The Reeler Malformation

1988 • 97 citations

Stabilization of a Specific Nuclear mRNA Precursor by Thyroid Hormone

1985 • 96 citations

Iodine and the Brain

1989 • 95 citations

Thyroid hormone and development of the rat hippocampus: Cell acquisition in the dentate gyrus

1986 • 93 citations

NEUROPSYCHOLOGICAL STUDY IN TREATED THYROID DYSGENESIS

1979 • 93 citations

Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain.

1976 • 92 citations

Audiogenic Seizures and Cochlear Damage in Rats after Perinatal Antithyroid Treatment*

1980 • 91 citations

Periods of Sensitivity to Thyroid Hormone during the Development of the Organ of Corti

1986 • 89 citations

The maturation of behaviour in hypothyroidism and starvation

1955 • 89 citations

Immature and mature variants of MAP2 and tau proteins and neuronal plasticity

1988 • 88 citations

Research in Congenital Hypothyroidism

1989 • 87 citations

HORMONES THYROIDIENNES ET MATURATION DU SYSTEME NERVEUX

1982 • 87 citations

Thyroid function in human pregnancy

1964 • 82 citations

Autoregulated control of tubilin synthesis in animal cells

1989 • 82 citations

Clathrin is axonally transported as part of slow component b: the microfilament complex.

1981 • 81 citations

Place learning in the Morris place navigation task is impaired by damage to the hippocampal formation even if the temporal demands are reduced

1988 • 81 citations

Iodine deficiency impairs intellectual and neuromotor development in apparently‐normal persons: A study of rural inhabitants of north‐central China

1989 • 81 citations

Thalamocortical connections in newborn mice

1984 • 81 citations

Programmed expression of beta-tubulin genes during development and differentiation of the chicken.

1984 • 80 citations

Axon strata of the cerebral wall in embryonic mice

1984 • 76 citations

A Comparative Study of Neurological and Myxedematous Endemic Cretinism in Western China*

1988 • 75 citations

Congenital Hypothyroidism with Impaired Thyroid Response to Thyrotropin

1968 • 75 citations

Neuronal differentiation in somatosensory cortex of the rat. I. Relationship to synaptogenesis in the first postnatal week

1978 • 72 citations

Effect of neonatal and adult-onset hypothyroidism on pyramidal cells of the rat auditory cortex

1983 • 70 citations

Developing forebrain astrocytes are sensitive to thyroid hormone

1990 • 68 citations

Growth and Maturation of the Rat Corticospinal Tract

1982 • 67 citations

Elementary school performance of children with congenital hypothyroidism

1990 • 67 citations

Tubulin Isotypes and the Multigene Tubulin Families

1983 • 62 citations

Triiodothyronine enhances the morphological maturation of dopaminergic neurons from fetal mouse hypothalamus cultured in serum-free medium

1983 • 60 citations

Effect of Thyroid Deficiency on the Growth of the Hippocampus in the Rat

1979 • 59 citations

Effects of Thyroid State on the Formation and Early Morphological Development of Bergmann Glia in the Developing Rat Cerebellum

1980 • 58 citations

INHERITED CONGENITAL GOITER IN MICE

1987 • 55 citations

A cloned cDNA encoding MAP1 detects a single copy gene in mouse and a brain-abundant RNA whose level decreases during development.

1986 • 54 citations

Axonal transport of a clathrin uncoating atpase (HSC70): A role for hsc70 in the modulation of coated vesicle assembly in vivo

1989 • 52 citations

Hypothyroidism: Learning deficit induced in rats by early exposure to thiouracil*1

1972 • 52 citations

Ontogenesis of the Rat Corticospinal Tract

1967 • 49 citations

Cerebral Palsy. A Clinical and Neuropathological Study

1968 • 49 citations

Thyroid function in human pregnancy

1971 • 49 citations

Induction of the ipsilateral retinothalamic projection in Xenopus laevis by thyroxine

1984 • 48 citations

Defective thyroid ontogenesis in fetal hypothyroid (hyt/hyt) mice

1982 • 48 citations

One β-tubulin subunit accumulates during neurite outgrowth in mouse neuroblastoma cells

1981 • 46 citations

The development of children with congenital hypothyroidism

1963 • 46 citations

Basic Neurochemistry

1989 • 46 citations

An etiologic and diagnostic study of cerebral palsy

1964 • 45 citations

Congenital Hypothyroidism Associated with Thyrotropin Unresponsiveness and Thyroid Cell Membrane Alterations

1980 • 45 citations

Development of the human cervical spinal cord with reference to synapse formation in the motro nucleus

1980 • 45 citations

Hypomyelination in the Cerebrum of the Congenitally Hypothyroid Mouse (hyt)

1984 • 45 citations

Do Neurotransmitters, Neurohumors, and Hormones Specify Critical Periods?

1986 • 45 citations

Effects of thyroid deficiency and corrective effects of thyroxine on microtubules and mitochondria in cerebellar Purkinje cell dendrites of developing rats

1983 • 44 citations

The congenital goiter mutation is linked to the thyroglobulin gene in the mouse.

1987 • 43 citations

Long‐term effects of propylthiouracil‐induced neonatal hypothyroidism

1979 • 42 citations

Behavioral Testing of Progenies of Tx (Hypothyroid) and Growth Hormone-Treated Tx Rats: An Animal Model for Mental Retardation

1984 • 42 citations

Axonal Transport of Microtubule Proteins: Cytotypic Variation of Tubulin and MAPs in Neuronsa

1986 • 41 citations

Psychoneuroendocrinology: Brain, Behavior, and Hormonal Interactions

1990 • 41 citations

Non-phosphorylated and phosphorylated neurofilaments in the cerebellum of the rat: an immunocytochemical study using monoclonal antibodies. Development in normal and thyroid-deficient animals

1986 • 39 citations

Synaptic organization of the molecular and the outer granular layer in the motor cortex in the white mouse during postnatal development. A Golgi- and electronmicroscopical study

1968 • 38 citations

Advances in Perinatal Thyroidology

1991 • 38 citations

Evaluation and Characterization of the Hypothyroid <i>hyt/hyt </i>Mouse I: Somatic and Behavioral Studies

1989 • 38 citations

Reversible Corticospinal Tract Disease Due to Hyperthyroidism

1977 • 37 citations

Neurologic complications of thyroid dysfunction.

1978 • 36 citations

Perinatal hypothyroidism in rats: Persistent motivational and metabolic effects

1976 • 34 citations

Neonatal Thyroid Deficiency: Early Temperamental and Cognitive Characteristics

1984 • 34 citations

Severity and timing of early thyroid deficiency as factors in the induction of learning disorders in rats

1976 • 34 citations

Cerebroside and Sulfatide Biosynthesis in the Brain of Snell Dwarf Mouse: Effects of Thyroxine and Growth Hormone in the Early Postnatal Period

1983 • 33 citations

Differential Effects of Cortical Lesions in Humans

2007 • 33 citations

Early brain insult and cognition: A comparison of malnutrition and hypothyroidism

1983 • 31 citations

Induction of brain tubulin by triidothyronine: dual effect of the hormone on the synthesis and turnover of the protein

1985 • 30 citations

Influence of triiodothyronine (l-T3) on the morphological and biochemical development of fetal brain acetylcholinesterase-positive neurons cultured in a chemically defined medium

1988 • 29 citations

Cell formation in the motor nucleus and mesencephalic nucleus of the trigeminal nerve of rats made hypothyroid by propylthiouracil

1985 • 29 citations

Evidence of hypothyroidism in the genetically epilepsy-prone rat

1988 • 26 citations

Histopathologische Befunde in Gehirnen von kongenitalem Myxödem (Thyreoaplasie)

1929 • 26 citations

Mutant gene-induced disorders of structure, function and thyroglobulin synthesis in congenital goitre (cog/cog) in mice

1990 • 25 citations

Infantile cerebral disorders Clinical-neuropathological correlations to elucidate the aetiological factors

1968 • 25 citations

An immunocytochemical and electron microscopic study of the hyt mouse anterior pituitary gland

1986 • 25 citations

Behavioral consequences of perinatal hypothyrodism in postnatal and adult rats

1985 • 24 citations

Ultrastructural Aspects of the Goiter in cog/cog Mice

1988 • 24 citations

Microtubules and neurofilaments in the sciatic nerve fibres of the developing rat: Effects of thyroid deficiency

1985 • 23 citations

IMPAIRED CYCLIC-AMP RESPONSE TO THYROTROPHIN IN CONGENITAL HYPOTHYROIDISM WITH THYROGLOBULIN DEFICIENCY

1979 • 23 citations

Effects of induced thyroid deficiency on the development of suckling behavior in rats

1982 • 22 citations

Infantile hypothyroidism then and now: The results of neonatal screening

1985 • 22 citations

DEFECTIVE THYROGLOBULIN EXPORT AS A CAUSE OF CONGENITAL GOITRE

1975 • 22 citations

THE EFFECTS ON FETAL BRAIN DEVELOPMENT IN THE RAT OF A SEVERELY IODINE DEFICIENT DIET DERIVED FROM AN ENDEMIC AREA: OBSERVATIONS ON THE FIRST GENERATION

1986 • 22 citations

Triiodothyronine (T3) induces neurite formation and increases synthesis of a protein related to MAP 1B in cultured cells of neuronal origin

1988 • 22 citations

The Postnatal Development of the Human Cerebral Cortex

1964 • 22 citations

Histogenesis of the anterior limb of the anterior commissure of the mouse brain. II. A quantitative study of pre- and postnatal mitosis.

1974 • 22 citations

Development of home orientation in hypothyroid and hyperthyroid rat pups

1980 • 21 citations

Iodine and the Brain

1989 • 20 citations

Differential Expression of the β‐Tubulin Multigene Family during Rat Brain Developmenta

1986 • 19 citations

Metabolic Mapping of Sensorimotor Integration in the Human Brain

2007 • 18 citations

The Site of the Molecular Defect in the Thyroid Gland of thehyt/hytMouse: Abnormalities in the TSH Receptor-G Protein Complex

1991 • 18 citations

Congenital Hypothyroidism: Intellectual and Neuropsychological Functioning

1990 • 18 citations

Alterations of Serum Thyroxine, Triiodothyronine, and Thyrotropin in the Progeny of Hypothyroid Rats*

1981 • 17 citations

THE DEVELOPMENT OF CHILDREN WITH CONGENITAL HYPOTHYRODISM

1983 • 17 citations

Axonal Transport Methods and Applications

2003 • 17 citations

Endocrine Studies of the Untreated Progeny of Thyroidectomized Rats

1975 • 16 citations

Effect of hypothyroidism on the expression of three microtubule-associated proteins (1A, IB and 2) in developing rat cerebellum

1988 • 16 citations

Perinatal, not adult, hypothyroidism suppresses dopaminergic axon sprouting in the deafferented olfactory tubercle of adult rat

1987 • 16 citations

Cellular and molecular aspects of neural development and regeneration

1987 • 15 citations

QUANTITATION AND CHARACTERIZATION OF BRAIN TUBULIN (COLCHICINE‐BINDING ACTIVITY) IN DEVELOPING HYPOTHYROID RATS

1978 • 14 citations

Effects of hypothyroidism on postnatal development in the peripheral vestibular system

1986 • 14 citations

CONGENITAL HYPOTHYROIDISM AND NEUROLOGICAL DEVELOPMENT

1983 • 14 citations

Morphological and functional effects of triiodothyronine on regenerating peripheral nerve

1986 • 13 citations

In Purkinje cell dendrites of the young rat, thyroid hormone controls the resistance of microtubules to fixation at low temperature

1984 • 13 citations

Influence of thyroid hormones on rat cerebellar cell aggregation and survival in culture

1986 • 13 citations

COMPARATIVE STUDY OF NEUROLOGICAL AND MYXOEDEMATOUS CRETINISM ASSOCIATED WITH SEVERE IODINE DEFICIENCY

1988 • 13 citations

Thyroid Influences on the Developing Cerebellum and Hippocampus of the Rat

1989 • 12 citations

Neurological Development in Congenital Hypothyroidism

1989 • 11 citations

Effect of maternal hypothyroxinaemia in the rat on brain biochemistry in adult progeny

1990 • 11 citations

Brain development in dwarf mice

1988 • 10 citations

Action of Thyroid Hormones on Brain Development

1989 • 9 citations

Cytotypic Specialization of the Neuronal Cytoskeleton and the Cytomatrix: Implications for Neuronal Growth and Regeneration

1988 • 7 citations

Reduced Axoplasmic Somatostatin Transport in Hypothyroid Rats

1985 • 6 citations

Mental Development of Patients with Congenital Hypothyroidism Detected by Screening: Quebec Experience

1989 • 6 citations

Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on tubulin content in fetal brains in rats.

1984 • 6 citations

Institutionalized cretins in the state of Michigan.

1959 • 6 citations

Early Correction of Iodine Deficiency and Late Effects on Psychomotor Capabilities and Migration

1989 • 5 citations

General Autopsy Findings and Neuropathological Techniques

1967 • 5 citations

Optic nerve hypoplasia with hyperthyroidism and third nerve palsy.

1980 • 3 citations

Ultrastructural aspects of the thyroid in a case of human congenital goitre with cretinism.

1975 • 3 citations

[Neurophysiological study of peripheral nerves in newborn infants with congenital hypothyroidism. Value in the surveillance of replacement therapy].

1988 • 2 citations