Growth factors modify the epidermal growth factor receptor through multiple pathways

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

The epidermal growth factor-induced calcium signal in A431 cells.

1986 • 297 citations

Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts

1984 • 232 citations

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

1984 • 219 citations

Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

1984 • 180 citations

Cancer cells. 3: Growth factors and transformation

1985 • 176 citations

Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

1983 • 168 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Platelet-derived growth factor treatment decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells.

1983 • 129 citations

Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alpha.

1985 • 111 citations

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

1985 • 101 citations

Effects of Epidermal Growth Factor and 12-O-Tetradecanoylphorbol-13-Acetate on Metabolism of the Epidermal Growth Factor Receptor in Normal Human Fibroblasts

1984 • 94 citations

Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.

1986 • 76 citations

Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.

1984 • 49 citations

Relationship between biological responsiveness to phorbol esters and receptor levels in GH4C1 rat pituitary cells.

1981 • 40 citations

Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.

1987 • 13 citations