Modulation of Endothelial Cell Apoptosis by Heme Oxygenase-1-Derived Carbon Monoxide

Caspases: Enemies Within

1998 • 6,923 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

The ferritins: molecular properties, iron storage function and cellular regulation

1996 • 2,572 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders

1998 • 2,263 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

1995 • 709 citations

Expression of heme oxygenase-1 can determine cardiac xenograft survival

1998 • 621 citations

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

1993 • 603 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Haem oxygenase-1 prevents cell death by regulating cellular iron

1999 • 519 citations

Heme oxygenase-1 protects against vascular constriction and proliferation

2001 • 515 citations

Defective smooth muscle regulation in cGMP kinase I-deficient mice

1998 • 510 citations

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1998 • 496 citations

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

1999 • 493 citations

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

1999 • 489 citations

NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival

1998 • 484 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

1987 • 466 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

2001 • 455 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

1997 • 406 citations

Cytokine regulation of endothelial cell function: from molecular level to the bedside

1997 • 403 citations

Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

2001 • 396 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

1998 • 382 citations

Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

1996 • 348 citations

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase

1997 • 332 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1.

1995 • 309 citations

An Inhibitor of p38 Mitogen-activated Protein Kinase Protects Neonatal Cardiac Myocytes from Ischemia

1999 • 300 citations

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

2000 • 296 citations

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.

1999 • 290 citations

Induction of Apoptosis by SB202190 through Inhibition of p38β Mitogen-activated Protein Kinase

1998 • 281 citations

Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B.

1996 • 252 citations

Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System

1996 • 242 citations

Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase‐1

1998 • 239 citations

Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase α, β, γ, and δ in Inflammatory Cell Lineages

1999 • 238 citations

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

1998 • 228 citations

MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner

1998 • 227 citations

Protective genes expressed in endothelial cells: a regulatory response to injury

1997 • 222 citations

Basis of guanylate cyclase activation by carbon monoxide.

1995 • 206 citations

Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells.

1997 • 204 citations

Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells

1999 • 192 citations

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

2000 • 192 citations

Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB

1999 • 174 citations

Purification and Identification of a Major Activator for p38 from Osmotically Shocked Cells

1996 • 166 citations

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

1999 • 152 citations

Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo

1995 • 115 citations

Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation

2002 • 111 citations

Murine p38-δ Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines

1999 • 96 citations

Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase

1988 • 95 citations

Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways.

1997 • 92 citations

Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B.

1997 • 85 citations

Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis

1998 • 82 citations

Protective Effects of Heme Oxygenase-1 in Acute Lung Injury

1999 • 68 citations