Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis.

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

2013 • 5,819 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Viral Hepatitis and Liver Disease

1985 • 1,886 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response

1996 • 832 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.

1995 • 483 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.

1991 • 363 citations

Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.

1994 • 345 citations

Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells

1996 • 341 citations

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

1993 • 333 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.

1991 • 330 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.

1991 • 302 citations

Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.

1996 • 299 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.

1996 • 294 citations

Definition of specific peptide motifs for four major HLA-A alleles.

1994 • 282 citations

Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients

1996 • 265 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Development, multiplexing, and application of ARMS tests for common mutations in the CFTR gene.

1992 • 246 citations

Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

1994 • 233 citations

Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen.

1991 • 230 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules

1995 • 216 citations

The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2.

1991 • 214 citations

Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype.

1995 • 213 citations

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

1996 • 201 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

Structural model of HLA-DR1 restricted T cell antigen recognition

1988 • 172 citations

Functional consequences of engagement of the T cell receptor by low affinity ligands.

1993 • 171 citations

Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.

1991 • 159 citations

Differences and similarities in the A2.1‐restricted cytotoxic T cell repertoire in humans and human leukocyte antigen‐transgenic mice

1996 • 119 citations

Hepatitis B Virus Immunopathogenesis

1995 • 116 citations

Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides.

1988 • 107 citations

Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.

1996 • 103 citations

Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types.

1991 • 100 citations

HLA class I nucleotide sequences, 1992

1992 • 96 citations

Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes

1995 • 92 citations

DNA typing for HLA class I alleles: I. Subsets of HLA-A2 and of -A28

1992 • 85 citations

Toward A Vaccine for AIDS: The Emergence of Immunobiology-Based Vaccine Development

1994 • 77 citations

Truncation analysis of several DR binding epitopes.

1991 • 76 citations

Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines

1992 • 66 citations

A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination.

1992 • 55 citations

Human tumor antigens recognized by T lymphocytes: implications for cancer therapy

1996 • 47 citations

The inhibition of different T cell lines specific for the same antigen with TCR antagonist peptides.

1993 • 34 citations

HLA Class I nucleotide sequences, 1991

1991 • 34 citations

Evaluation of hepatitis C virus protein epitopes for vaccine development

1996 • 18 citations

Toward a Vaccine for AIDS: The Emergence of Immunobiology-Based Vaccine Development

1994 • 5 citations