Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat

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Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

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A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia

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CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

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Neuronal Necrosis After Middle Cerebral Artery Occlusion in Wistar Rats Progresses at Different Time Intervals in the Caudoputamen and the Cortex

1995 • 349 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Electron Microscopic Evidence against Apoptosis as the Mechanism of Neuronal Death in Global Ischemia

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Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

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1997 • 240 citations

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A model of Perinatal Hypoxic‐Ischemic Brain Damage^a

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Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase Activation

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Apoptosis in a Neonatal Rat Model of Cerebral Hypoxia-Ischemia

1998 • 203 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia–ischaemia

1997 • 196 citations

Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat

1998 • 190 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain

1997 • 173 citations

Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons

1998 • 164 citations

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death

1998 • 163 citations

Exacerbation of Ischemic Brain Damage by Localized Striatal Injection of Interleukin-1β in the Rat

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Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury

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Apoptosis and protein expression after focal cerebral ischemia in rat

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A Model of Transient Unilateral Focal Ischemia With Reperfusion in the P7 Neonatal Rat

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1995 • 139 citations

Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study

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Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity

1998 • 136 citations

Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult

1994 • 130 citations

Neuronal Death in Newborn Striatum after Hypoxia-Ischemia Is Necrosis and Evolves with Oxidative Stress

2000 • 129 citations

Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?

1999 • 115 citations

Ultrastructural detection of DNA strand breaks in apoptotic neural cells by in situ end‐labelling techniques

1995 • 112 citations

Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat

1996 • 105 citations

Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia

1998 • 96 citations

Apoptosis in Focal Cerebral Ischemia

1996 • 94 citations

Susceptibility to apoptosis is enhanced in immature cortical neurons

1997 • 92 citations

Asynchrony and Commitment to Die during Apoptosis

1998 • 92 citations

Nature, time-course, and extent of cerebral edema in perinatal hypoxic-ischemic brain damage

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Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats

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Postnatal distribution ofcpp32/caspase 3 mRNA in the mouse central nervous system: An in situ hybridization study

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Cell death in perinatal hypoxic–ischaemic brain injury

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Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. metabotropic receptors

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Apoptosis and programmed cell death: a role in cerebral ischemia

1998 • 36 citations

Immunolocalization of caspase proteolysis in situ: evidence for widespread caspase-mediated apoptosis of neurons and glia in the postnatal rat brain

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[Apoptosis in the nervous system].

1996 • 25 citations

Apoptosis Detection in Brain Using Low-Magnification Dark-Field Microscopy

1999 • 15 citations

Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischaemia

1997 • 13 citations

Cell death in perinatal hypoxic-ischaemic brain injury

1997 • 1 citations