Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40).

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury

2001 • 614 citations

The biology of SPARC, a protein that modulates cell‐matrix interactions

1994 • 533 citations

Cloning and characterization of five overlapping cDNAs specific for the human proα 1(I) collagen chain

1982 • 496 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Wound repair in the context of extracellular matrix

1994 • 435 citations

The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

1992 • 358 citations

Osteopenia and decreased bone formation in osteonectin-deficient mice

2000 • 319 citations

Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells

1997 • 229 citations

Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.

1993 • 217 citations

SPARC deficiency leads to early-onset cataractogenesis.

1998 • 198 citations

Isolation and characterization of cDNA clones for human and bovine fibronectins.

1983 • 184 citations

SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-β1 in Mesangial Cells

1999 • 182 citations

Purification and tissue distribution of a small protein (BM-40) extracted from a basement membrane tumor

1986 • 157 citations

SPARC antagonizes the effect of basic fibroblast growth factor on the igration of bovine aortic endothelial cells

1992 • 142 citations

SPARC: a potential diagnostic marker of invasive meningiomas.

1999 • 134 citations

Primary Mesenchymal Cells Isolated from SPARC-null Mice Exhibit Altered Morphology and Rates of Proliferation

1999 • 92 citations

Differential modulation of cell adhesion by interaction between adhesive and counter-adhesive proteins: characterization of the binding of vitronectin to osteonectin (BM40, SPARC)

1997 • 90 citations

Disruption of theSparcLocus in Mice Alters the Differentiation of Lenticular Epithelial Cells and Leads to Cataract Formation

1999 • 87 citations

Terms of attachment: SPARC and tumorigenesis

1997 • 85 citations

Localization of collagen α1(I) gene expression during wound healing by in situ hybridization

1989 • 78 citations

Lenses of SPARC-null Mice Exhibit an Abnormal Cell Surface–Basement Membrane Interface

2000 • 65 citations

Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: Implications for fibroblast function

1996 • 56 citations

Osteonectin/SPARC Regulates Cellular Secretion Rates of Fibronectin and Laminin Extracellular Matrix Proteins

1994 • 43 citations

The Counteradhesive Protein SPARC Regulates an Endothelial Paracellular Pathway through Protein Tyrosine Phosphorylation

1998 • 34 citations

Localization of Collagen alpha1(I) Gene Expression During Wound Healing by In Situ Hybridization.

1989 • 33 citations

Down-regulation of the extracellular matrix protein SPARC in vSrc- and vJun-transformed chick embryo fibroblasts contributes to tumor formation in vivo

2000 • 32 citations

Changes in cytokeratin expression in epidermal keratinocytes during wound healing

1995 • 27 citations

A calcium‐binding motif in SPARC/osteonectin inhibits chordomesoderm cell migration during Xenopus laevis gastrulation: Evidence of counter‐adhesive activity in vivo

1999 • 27 citations

Loss of insulin-like growth factor I receptor-dependent expression of p107 and cyclin A in cells that lack the extracellular matrix protein secreted protein acidic and rich in cysteine.

1999 • 9 citations