The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Osteonectin, a bone-specific protein linking mineral to collagen

1981 • 1,131 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment

1987 • 636 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin

1991 • 560 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Platelet-derived growth factor: mechanism of action and possible in vivo function.

1990 • 491 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.

1989 • 375 citations

In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.

1987 • 292 citations

INDUCTION OF B-TYPE RECEPTORS FOR PLATELET-DERIVED GROWTH FACTOR IN VASCULAR INFLAMMATION: POSSIBLE IMPLICATIONS FOR DEVELOPMENT OF VASCULAR PROLIFERATIVE LESIONS

1988 • 247 citations

The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor.

1988 • 240 citations

Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets

1990 • 226 citations

The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells.

1991 • 223 citations

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

1991 • 220 citations

Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues

1987 • 211 citations

Isolation and characterization of native adult osteonectin.

1985 • 207 citations

Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.

1990 • 203 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

Distribution of the calcium-binding protein SPARC in tissues of embryonic and adult mice.

1989 • 192 citations

Osteonectin cDNA sequence reveals potential binding regions for calcium and hydroxyapatite and shows homologies with both a basement membrane protein (SPARC) and a serine proteinase inhibitor (ovomucoid).

1988 • 189 citations

Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin.

1984 • 186 citations

The high molecular weight receptor to transforming growth factor-beta contains glycosaminoglycan chains.

1988 • 178 citations

Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes

1988 • 172 citations

Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape.

1990 • 164 citations

Human microvascular endothelial cells express receptors for platelet-derived growth factor.

1991 • 154 citations

Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

1989 • 153 citations

Human platelets contain and secrete osteonectin, a major protein of mineralized bone.

1986 • 148 citations

The Effects of Platelet-Derived Growth Factor in Cultured Microvessel Endothelial Cells*

1989 • 137 citations

Platelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons. Association in vivo of platelet-derived growth factor mRNA and protein with cellular proliferation.

1991 • 122 citations

Plasma binding proteins for platelet-derived growth factor that inhibit its binding to cell-surface receptors.

1984 • 95 citations

Relative Platelet-derived Growth Factor Receptor Subunit Expression Determines Cell Migration to Different Dimeric Forms of PDGF

1990 • 87 citations

The B chain of PDGF alone is sufficient for mitogenesis.

1985 • 50 citations

Isolation and chemical characterization of the phosphoproteins of chicken bone matrix: heterogeneity in molecular weight and composition

1986 • 47 citations

Importance of PDGF receptor expression in accelerated atherosclerosis-chronic rejection.

1989 • 32 citations

[5] Identification and assay of platelet-derived growth factor-binding proteins

1987 • 17 citations