Drugs targeting the renin–angiotensin–aldosterone system

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure

1997 • 5,689 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

2001 • 3,093 citations

A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure

2001 • 3,065 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

2000 • 2,991 citations

A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure

1991 • 2,867 citations

The world health report 2001 - Mental health: new understanding, new hope

2001 • 2,803 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

International union of pharmacology. XXIII. The angiotensin II receptors.

2000 • 2,055 citations

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

1999 • 2,051 citations

Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II

2000 • 1,956 citations

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

1977 • 1,851 citations

Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials

2000 • 1,789 citations

Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)

1997 • 1,680 citations

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 1,592 citations

Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials

1995 • 1,526 citations

Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study

1999 • 1,472 citations

Preserving renal function in adults with hypertension and diabetes: A consensus approach

2000 • 1,406 citations

Overview of Randomized Trials of Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Patients With Heart Failure

1995 • 1,301 citations

Effect of Captopril on Progressive Ventricular Dilatation after Anterior Myocardial Infarction

1988 • 1,119 citations

Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke

1972 • 1,098 citations

Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease

2001 • 1,050 citations

The Renin-Angiotensin System

1978 • 969 citations

Effect of Ramipril vs Amlodipine on Renal Outcomes in Hypertensive Nephrosclerosis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2001 • 931 citations

Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure

2000 • 928 citations

Comparison of Candesartan, Enalapril, and Their Combination in Congestive Heart Failure

1999 • 898 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Association of the Renin-Sodium Profile with the Risk of Myocardial Infarction in Patients with Hypertension

1991 • 734 citations

Angiotensin II receptor antagonists

2000 • 706 citations

Reversal of Left Ventricular Hypertrophy in Essential Hypertension

1996 • 609 citations

Rationale and Design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

1996 • 598 citations

Angiotensin Receptors and Their Antagonists

1996 • 568 citations

Indications for ACE inhibitors in the early treatment of acute myocardial infarction - Systematic overview of individual data from 100,000 patients in randomized trials

1998 • 549 citations

Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.

1995 • 539 citations

Indications for ACE Inhibitors in the Early Treatment of Acute Myocardial Infarction

1998 • 527 citations

Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection.

1994 • 511 citations

Mineralocorticoid excess, dietary sodium, and myocardial fibrosis.

1992 • 499 citations

A BRADYKININ‐POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARACA

1965 • 488 citations

Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase

2001 • 450 citations

Effect of Bradykinin-Receptor Blockade on the Response to Angiotensin-Converting–Enzyme Inhibitor in Normotensive and Hypertensive Subjects

1998 • 446 citations

Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study

1996 • 443 citations

Effect of Angiotensin-Converting Enzyme Inhibitors on the Progression of Nondiabetic Renal Disease

1997 • 436 citations

Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.

1993 • 409 citations

Converting-Enzyme Inhibitors in the Treatment of Hypertension

1988 • 362 citations

Converting Enzyme Inhibition Specifically Prevents the Development and Induces Regression of Cardiac Hypertrophy in Rats

1989 • 344 citations

Role of Bradykinin in Mediating Vascular Effects of Angiotensin-Converting Enzyme Inhibitors in Humans

1997 • 332 citations

THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE

1957 • 320 citations

Post-stroke antihypertensive treatment study. A preliminary result

1995 • 311 citations

The Renin-Angiotensin System

1974 • 307 citations

Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV.

1995 • 303 citations

Long-term Renoprotective Effect of Angiotensin-converting Enzyme Inhibition in Non—insulin-dependent Diabetes Mellitus

1996 • 297 citations

Vasopeptidase Inhibitors

2001 • 296 citations

Trends in the Prevalence of Hypertension, Antihypertensive Therapy, and Left Ventricular Hypertrophy from 1950 to 1989

1999 • 281 citations

Effect of Activation and Inhibition of the Renin-Angiotensin System on Plasma PAI-1

1998 • 273 citations

Efficacy and tolerance of spironolactone in essential hypertension

1987 • 268 citations

Comparative Efficacy of Olmesartan, Losartan, Valsartan, and Irbesartan in the Control of Essential Hypertension

2001 • 264 citations

A Comparative Study of the Distributions of Renin and Angiotensinogen Messenger Ribonucleic Acids in Rat and Mouse Tissues*

1987 • 260 citations

Functional and Biochemical Analysis of Angiotensin II–Forming Pathways in the Human Heart

1997 • 246 citations

Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade.

1982 • 243 citations

A specific B₂‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril

1992 • 236 citations

Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.

1996 • 230 citations

Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations

1997 • 223 citations

Proposed Update of Angiotensin Receptor Nomenclature

1995 • 220 citations

Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.

1997 • 216 citations

Angiotensin II-Forming Activity in a Reconstructed Ancestral Chymase

1996 • 210 citations

The role of spironolactone in the treatment of patients with refractory hypertension

2002 • 204 citations

Antihypertensive Therapy with MK 4211

1982 • 188 citations

ABPM comparison of the antihypertensive profiles of the selective angiotensin II receptor antagonists telmisartan and losartan in patients with mild-to-moderate hypertension

1999 • 179 citations

Pilot study of the uricosuric effect of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects

1992 • 174 citations

Angiotensin II antagonists for hypertension: are there differences in efficacy?

2000 • 173 citations

[Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomized trials].

2001 • 167 citations

Cardiovascular drug therapy

1965 • 166 citations

Bradykinin Stimulates Tissue Plasminogen Activator Release in Human Vasculature

1999 • 153 citations

Cardiac angiotensinogen and its local activation in the isolated perfused beating heart.

1990 • 152 citations

Cloning and characterization of a human angiotensin II type 1 receptor

1992 • 152 citations

The Antihypertensive Effect and Tolerability of Candesartan Cilexetil, a New Generation Angiotensin II Antagonist, in Comparison with Losartan

1998 • 136 citations

Björn Fokow Award Lecture The angiotensin type 2 receptor

1999 • 133 citations

Cardiac aldosterone production and ventricular remodeling

2000 • 117 citations

The Angiotensin II Type 1 Receptor Antagonists

1995 • 114 citations

Physiological and Pathophysiological Functions of the AT ₂ Subtype Receptor of Angiotensin II

2001 • 114 citations

Superoxide Production, Risk Factors, and Endothelium-Dependent Relaxations in Human Internal Mammary Arteries

1999 • 101 citations

Vasopeptidase inhibitors

2001 • 95 citations

An elective-titration study of the comparative effectiveness of two angiotensin II-receptor blockers, irbesartan and losartan

1998 • 94 citations

Angioedema Associated With Angiotensin II Receptor Antagonists: Challenging Our Knowledge of Angioedema and Its Etiology

2001 • 94 citations

Book ReviewHuman Gene Therapy

1988 • 93 citations

Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart

1993 • 92 citations

Extra-adrenal Mineralocorticoids and Cardiovascular Tissue

1999 • 87 citations

In vitro and in vivo pharmacology of olmesartan medoxomil, an angiotensin II type AT1 receptor antagonist

2001 • 85 citations

Transient upregulation of the AT2 receptor mRNA level after global ischemia in the rat brain

1996 • 85 citations

Hypertension : a companion to Brenner and Rector's the kidney

2000 • 77 citations

Angiotensin II Receptor Blockade: An Innovative Approach to Cardiovascular Pharmacotherapy

1993 • 76 citations

The new oral angiotensin II antagonist olmesartan medoxomil: a concise overview

2002 • 74 citations

Biological properties of the angiotensin peptides other than angiotensin II: implications for hypertension and cardiovascular diseases

2002 • 73 citations

Inhibitors of Renin as Potential Therapeutic Agents

1987 • 69 citations

The chymase-angiotensin system in humans

1993 • 69 citations

Choosing the Right ACE Inhibitor

1995 • 69 citations

Hypertension: A Companion to Brenner and Rector's The Kidney

2000 • 61 citations

Effects of candesartan cilexetil in patients with systemic hypertension

1998 • 57 citations

Effects of candesartan cilexetil in patients with severe systemic hypertension

1999 • 56 citations

Resistant hypertension

2002 • 54 citations

Angiotensin AT2 Receptor Stimulation Increases Survival in Gerbils with Abrupt Unilateral Carotid Ligation

1994 • 54 citations

Protection against ischemia: a physiological function of the renin-angiotensin system22Abbreviations: RAS, renin-angiotensin system; ACE, angiotensin-converting enzyme; NO, nitric oxide; cGMP, cyclic GMP; GBM, glioblastoma multiforme; and SHR, spontaneously hypertensive rat.

2001 • 50 citations

Contribution of circulating renin to local synthesis of angiotensin peptides in the heart

2000 • 49 citations

Effects of bradykinin B₂ receptor antagonism on the hypotensive effects of ACE inhibition

1994 • 41 citations

Cardiovascular Drug Therapy.

1975 • 38 citations

Antihypertensive drug therapy and survival by treatment status in a national survey.

1989 • 32 citations

Bradykinin pathway is involved in acute hemodynamic effects of enalaprilat in dogs with heart failure

1996 • 32 citations

Converting-enzyme inhibitors increase converting-enzyme mRNA and activity in endothelial cells

1992 • 31 citations

Manual of hypertension

1995 • 27 citations

New Therapeutic Agents in the Management of Hypertension: Angiotensin II-Receptor Antagonists and Renin Inhibitors

1993 • 20 citations

Mineralocorticoid receptors and hypertension

1995 • 19 citations

Microalbuminuria reduction with valsartan

2001 • 17 citations

Endogenous xanthine oxidase-derived O2 metabolites inhibit surfactant metabolism

1990 • 15 citations

Dose response antihypertensive efficacy of aliskiren (SPP 100), an orally active renin inhibitor

2002 • 9 citations

The selective aldosterone blocker eplerenone is safe and efficacious for the long-term treatment of mild-to-moderate hypertension

2002 • 7 citations