Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Molecular Mechanisms of Myocardial Remodeling

1999 • 1,456 citations

Collagen remodeling after myocardial infarction in the rat heart.

1995 • 538 citations

Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen

1990 • 531 citations

Infarct scar: a dynamic tissue

2000 • 500 citations

Mineralocorticoid excess, dietary sodium, and myocardial fibrosis.

1992 • 499 citations

Mineralocorticoids, hypertension, and cardiac fibrosis.

1994 • 440 citations

Anti-Aldosterone Treatment and the Prevention of Myocardial Fibrosis in Primary and Secondary Hyperaldosteronism

1993 • 432 citations

The alpha-smooth muscle actin-positive cells in healing human myocardial scars.

1994 • 380 citations

Serum Carboxy-Terminal Propeptide of Procollagen Type I Is a Marker of Myocardial Fibrosis in Hypertensive Heart Disease

2000 • 358 citations

Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type III procollagen.

1988 • 347 citations

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

1997 • 342 citations

Incidence, clinical and etiologic features, and outcomes of advanced chronic heart failure: the EPICAL study

1999 • 299 citations

Abnormalities of the Extracellular Degradation of Collagen Type I in Essential Hypertension

1998 • 296 citations

Immunoassay for intact amino-terminal propeptide of human type I procollagen

1996 • 286 citations

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions

1993 • 270 citations

Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis

1995 • 254 citations

Increased Serum Concentrations of Procollagen Peptides in Essential Hypertension

1995 • 218 citations

Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension.

1994 • 179 citations

Analysis of healing after myocardial infarction using polarized light microscopy.

1989 • 167 citations

Temporal differences in fibroblast proliferation and phenotype expression in response to chronic administration of angiotensin II or aldosterone

1995 • 137 citations

Collagen Scar Formation After Acute Myocardial Infarction

1997 • 124 citations

Serum Markers of Collagen Type I Metabolism in Spontaneously Hypertensive Rats

1996 • 121 citations

Analysing connective tissue metabolites in human serum. Biochemical, physiological and methodological aspects.

1995 • 120 citations

Aldosterone and cardiac fibrosis: in vitro studies

1994 • 108 citations

Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction.

1990 • 85 citations

Thrombolytic therapy with streptokinase stimulates collagen breakdown.

1991 • 80 citations

Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation

1993 • 80 citations

Measuring serum aminoterminal type III procollagen peptide, 7S domain of type IV collagen, and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy

1997 • 78 citations

The aminoterminal propeptide of type III procollagen provides new information on prognosis after acute myocardial infarction

1995 • 77 citations

Aldosterone and heart failure

1995 • 64 citations

Analytical Aspects Regarding the Measurement of Metalloproteinases and Their Inhibitors in Blood

1997 • 62 citations

Monitoring fibrillar collagen turnover in hypertensive heart disease

1997 • 60 citations

Quantitating coronary collateral flow velocity in patients during coronary angioplasty using a Doppler guidewire

1993 • 56 citations

Antagonism of the renin-angiotensin-aldosterone system and collagen metabolism in cardiac fibroblasts

1999 • 41 citations

Angiotensin-converting enzyme inhibitor and spironolactone combination therapy

1993 • 39 citations

Studies on collagen in the experimental myocardial infarction.

1985 • 23 citations