Functional and Biochemical Analysis of Angiotensin II–Forming Pathways in the Human Heart

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

1992 • 1,956 citations

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury

1989 • 1,061 citations

Angiotensin II-forming pathways in normal and failing human hearts.

1990 • 585 citations

Concentrations of angiotensin-converting enzyme in tissues of the rat

1971 • 415 citations

Angiotensin-converting enzyme: new concepts concerning its biological role

1989 • 400 citations

Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.

1993 • 397 citations

Converting-Enzyme Inhibitors in the Treatment of Hypertension

1988 • 362 citations

Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade.

1982 • 243 citations

Additive Effects of Combined Angiotensin-Converting Enzyme Inhibition and Angiotensin II Antagonism on Blood Pressure and Renin Release in Sodium-Depleted Normotensives

1995 • 221 citations

Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension.

1990 • 191 citations

Antihypertensive Therapy with MK 4211

1982 • 188 citations

Microinjection of α-Calcitonin Gene-Related Peptide into the Hypothalamus Activates Sympathetic Outflow in Rats

1993 • 160 citations

Cloning of the gene and cDNA for human heart chymase.

1991 • 154 citations

Different distribution of two types of angiotensin II-generating enzymes in the aortic wall

1987 • 151 citations

Specific measurement of angiotensin metabolites and in vitro generated angiotensin II in plasma.

1986 • 133 citations

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart.

1991 • 127 citations

Angiotensin II formation in the intact human heart. Predominance of the angiotensin-converting enzyme pathway.

1995 • 123 citations

Plasma angiotensins and blood pressure during converting enzyme inhibition.

1987 • 117 citations

Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells.

1989 • 112 citations

Progression of left ventricular dysfunction secondary to coronary artery disease, sustained neurohormonal activation and effects of ibopamine therapy during long-term therapy with angiotensin-converting enzyme inhibitor

1994 • 107 citations

Tissue Renin-Angiotensin Systems: Focus on the Heart

1987 • 88 citations

Activation of two angiotensin‐generating systems in the balloon‐injured artery

1993 • 88 citations

Effects of angiotensin II generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboon.

1995 • 77 citations

Cilazapril and early atherosclerotic changes after balloon injury of porcine carotid arteries.

1992 • 76 citations

Evidence for a role of an intracardiac renin-angiotensin system in normal and failing hearts

1993 • 75 citations

Angiotensin-Converting Enzyme Inhibitors in Hypertension

1994 • 72 citations

Measurement of angiotensin I converting enzyme inhibition in the heart.

1993 • 71 citations

Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure.

1992 • 70 citations

Angiotensin II formation by an alternative pathway during exercise in humans

1994 • 65 citations

Renal Circulation and Blockade of the Renin-Angiotensin System

1995 • 62 citations

Corcoran Lecture. Angiotensin-converting enzyme inhibition and the heart.

1994 • 56 citations

Effects of Blocking the Angiotensin II Receptor, Converting Enzyme, and Renin Activity on the Renal Hemodynamics of Normotensive Guinea Pigs

1993 • 45 citations

Direct evidence for the presence of a different converting enzyme in the hamster cheek pouch.

1979 • 44 citations

Direct formation of angiotensin II without renin or converting enzyme in the ischemic dog heart.

1989 • 44 citations

Differing Early Blood Pressure and Renin-Angiotensin System Responses to the First Dose of Angiotensin-Converting Enzyme Inhibitors in Congestive Heart Failure

1996 • 40 citations

Beneficial effects of a serine protease inhibitor in peripheral vascular disease

1993 • 23 citations