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p53, the Cellular Gatekeeper for Growth and Division

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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Mdm2 promotes the rapid degradation of p53

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1996 • 2,304 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

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HIF-1alpha is required for solid tumor formation and embryonic vascularization

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Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

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Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

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Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

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Angiogenesis and Tumor Metastasis

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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Loss of PTEN facilitates HIF-1-mediated gene expression

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Stabilization of wild-type p53 by hypoxia-inducible factor 1α

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Understanding Ras: ‘it ain’t over ’til it’s over’

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p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

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Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

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Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

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Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

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Expression of hypoxia-inducible factor 1? in brain tumors

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1997 • 526 citations

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Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

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Activating SRC mutation in a subset of advanced human colon cancers

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Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

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The VHL tumour-suppressor gene paradigm

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Down-regulation of Vascular Endothelial Growth Factor in a Human Colon Carcinoma Cell Line Transfected with an Antisense Expression Vector Specific for c-src

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Novel anticancer drug discovery

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Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma

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1996 • 27 citations

Tumor angiogenesis: A physiological process or genetically determined?

1996 • 27 citations

Oxygen Transport in Tumors

1996 • 26 citations