Specific Promoter Methylations Cause Gene Inactivation

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Genomic sequencing.

1984 • 8,343 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.

1977 • 2,233 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1981 • 873 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

5-Methylcytosine in Eukaryotic DNA

1981 • 744 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.

1982 • 575 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 • 496 citations

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

1981 • 475 citations

Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.

1980 • 471 citations

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

1983 • 467 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.

1982 • 396 citations

MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites

1978 • 395 citations

Specific DNA methylation sites in the vicinity of the chicken β-globin genes

1979 • 365 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

1981 • 353 citations

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

1977 • 335 citations

Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression.

1980 • 309 citations

The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets

1981 • 290 citations

Promoters and heterogeneous 5′ termini of the messenger RNAs of adenovirus serotype 2

1981 • 289 citations

Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29

1983 • 287 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

1982 • 253 citations

Inhibition of DNA methylation by chemical carcinogens in vitro

1983 • 252 citations

DNA-binding Proteins specific for Cells infected by Adenovirus

1973 • 247 citations

The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter

1983 • 241 citations

Selective Silencing of Eukaryotic DNA

1975 • 224 citations

Specificity of<u>Hpa</u>II and<u>Hae</u>II DNA methylases

1977 • 221 citations

Correlation between Hypomethylation of DNA and Expression of Globin Genes in Friend Erythroleukemia Cells

1977 • 209 citations

Induction of thymidine kinase in enzyme-deficient chinese hamster cells

1982 • 205 citations

Dna Methylation and its Possible Biological Roles

1981 • 202 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

DNA Methylation--A Regulatory Signal in Eukaryotic Gene Expression

1981 • 192 citations

Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells

1981 • 190 citations

Expression of a cloned adenovirus gene is inhibited by in vitro methylation.

1982 • 184 citations

Methylation of Herpesvirus saimiri DNA in lymphoid tumor cell lines

1979 • 179 citations

Unusual methylation pattern of the α2(I) collagen gene

1982 • 177 citations

Patterns of integration of viral dna sequences in the genomes of adenovirus type 12-transformed hamster cells

1978 • 177 citations

Building for Earthquakes

2004 • 157 citations

DNA methylation in adenovirus, adenovirus-transformed cells, and host cells.

1976 • 155 citations

Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA

1980 • 155 citations

Hypomethylation of DNA during differentiation of friend erythroleukemia cells

1980 • 154 citations

Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine.

1982 • 149 citations

Pattern of methylation of two genes coding for housekeeping functions.

1983 • 148 citations

Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene.

1982 • 142 citations

Asymmetrical distribution of CpG in an ‘average’ mammalian gene

1982 • 140 citations

Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of promoter methylation on gene expression.

1983 • 139 citations

DNA methylation and viral gene expression in adenovirus-transformed and-infected cells

1980 • 131 citations

Undermethylation at the 5′ end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture

1982 • 124 citations

Structure and gene organization in the transforming Hind III-G fragment of Ad12

1980 • 119 citations

Integration Sites of Adenovirus Type 12 DNA in Transformed Hamster Cells and Hamster Tumor Cells

1980 • 118 citations

Transcription of the genome of adenovirus type 12. III. Maps of stable RNA from productively infected human cells and abortively infected and transformed hamster cells

1976 • 108 citations

DNA methylation of three 5' C-C-G-G 3' sites in the promoter and 5' region inactivate the E2a gene of adenovirus type 2.

1984 • 105 citations

Functional analysis of a herpes simplex virus type 1 promoter: identification of far-upstream regulatory sequences

1983 • 98 citations

Quantitative determination of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography

1983 • 95 citations

Changes in the helical repeat of poly(dG-m5 dC) · poly(dG-m5dC) and poly(dG-dC) · poly(dG-dC) associated with the B—Z transition

1981 • 94 citations

Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells.

1982 • 88 citations

In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated

1983 • 87 citations

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

1982 • 85 citations

Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2

1978 • 84 citations

Delimitation of a promoter for RNA polymerase III by means of a functional test.

1979 • 79 citations

The unmethylated state of the promoter/leader and 5′-regions of integrated adenovirus genes correlates with gene expression.

1982 • 79 citations

Host response to adenovirus 2-transformed hamster embryo cells.

1979 • 75 citations

An unusual symmetric recombinant between adenovirus type 12 DNA and human cell DNA

1981 • 73 citations

Role of Methylation in the Induced and Spontaneous Expression of the Avian Endogenous Virusev-1: DNA Structure and Gene Products

1982 • 69 citations

Effect of methylation on expression of microinjected genes.

1982 • 61 citations

Shifts in the extent and patterns of DNA methylation upon explantation and subcultivation of adenovirus type 12-induced hamster tumor cells

1982 • 60 citations

Morphological Revertants of Adenovirus Type 12-transformed Hamster Cells

1978 • 59 citations

DNA methylation in chicken alpha-globin gene expression.

1982 • 58 citations

Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells

1980 • 57 citations

Methylation of Integrated Viral DNA Sequences in Hamster Cells Transformed by Adenovirus 12

1980 • 54 citations

Expression of Early Viral Gene Products in Adenovirus Type 12-infected and -transformed cells

1982 • 54 citations

Nucleotide sequence at the site of junction between adenovirus type 12 DNA and repetitive hamster cell DNA in transformed cell line CLAC1

1982 • 53 citations

Patterns of integration of viral DNA in adenovirus type 2-transformed hamster cells

1981 • 51 citations

Expression of Viral DNA in Adenovirus Type 12-Transformed Cells, in Tumor Cells, and in Revertants

1981 • 47 citations

Comparison of the methylation patterns of the two rat insulin genes.

1983 • 44 citations

Revertants of Adenovirus Type 12-Transformed Hamster Cell Line T637 as Tools in the Analysis of Integration Patterns

1980 • 44 citations

Proof of recombination between viral and cellular genomes in human KB cells productively infected by adenovirus type 12: structure of the junction site in a symmetric recombinant (SYREC)

1983 • 42 citations

Loss of viral genomes from hamster tumor cells and nonrandom alterations in patterns of methylation of integrated adenovirus type 12 DNA

1983 • 42 citations

In Vitro Methylation of Specific Regions of the Cloned Moloney Sarcoma Virus Genome Inhibits Its Transforming Activity

1983 • 42 citations

Enzymatic dna methylation in higher eukaryotes

1980 • 36 citations

Structure, stability, methylation, expression and glucocorticoid induction of endogenous and transfected proviral genes of mouse mammary tumor virus in mouse fibroblasts

1981 • 35 citations

Methylation of adenovirus genes in transformed cells and in vitro: influence on the regulation of gene expression?

1981 • 35 citations

DNA Methylation and Its Functional Significance: Studies on the Adenovirus System

1984 • 34 citations

Restriction and modification in Bacillus subtilis: two DNA methyltransferases with BsuRI specificity. II. Catalytic properties, substrate specificity, and mode of action.

1981 • 34 citations

Coupled Demethylation of Sites in a Conserved Sequence of Xenopus Ribosomal DNA

1983 • 33 citations

Viral gene products in adenovirus type-2 transformed hamster cells

1982 • 30 citations

Integrated adenovirus type 12 DNA in the transformed hamster cell line T637: sequence arrangements at the termini of viral DNA and mode of amplification

1982 • 29 citations

In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity.

1983 • 29 citations

Transcription of the Genome of Adenovirus Type 12. Viral mRNA in Productively Infected KB Cells

1975 • 28 citations

DNA Methylation and Gene Activity: The Adenovirus System as a Model

1983 • 25 citations

Different levels of DNA modification at 5'CCGG in murine erythroleukemia cells and the tissues of normal mouse spleen

1982 • 23 citations

In Vitro Methylation of theBsuRI (5′-GGCC-3′) Sites in the E2a Region of Adenovirus Type 2 DNA Does Not Affect Expression inXenopus laevisOocytes

1982 • 22 citations

Structure and Expression of the Human Globin Genes and Murine Histoeompatability Antigen Genes

1983 • 22 citations

Revertants of adenovirus type‐12‐transformed hamster cells have lost part of the viral genomes

1979 • 20 citations

Methylation of viral DNA in Vivo and in Vitro

1979 • 19 citations

Excision of amplified viral DNA at palindromic sequences from the adenovirus type 12-transformed hamster cell line T637.

1983 • 10 citations

Can DNA Methylation Regulate Gene Expression?

1983 • 6 citations