5 Acetyl-Coenzyme A Carboxylase

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Studies on the Metabolism of Adipose Tissue

1964 • 390 citations

Mechanisms and regulation of biosynthesis of saturated fatty acids.

1976 • 340 citations

A MALONIC ACID DERIVATIVE AS AN INTERMEDIATE IN FATTY ACID SYNTHESIS

1958 • 338 citations

Regulation of Hepatic Acetyl Coenzyme A Carboxylase by Phosphorylation and Dephosphorylation

1973 • 337 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Control Mechanisms in the Synthesis of Saturated Fatty Acids

1977 • 324 citations

Molecular Basis of Insulin Action

1985 • 309 citations

Evidence for the participation of biotin in the enzymic synthesis of fatty acids

1958 • 282 citations

The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.

1978 • 269 citations

Biotin Enzymes

1977 • 257 citations

Acetyl coenzyme A carboxylase.

1974 • 216 citations

A partial view of the mechanism of insulin action

1981 • 215 citations

Molecular basis of insulin action

1986 • 201 citations

Perfusion in Situ with Tritium Oxide to Measure Hepatic Lipogenesis and Lipid Secretion

1966 • 190 citations

The Concentration of Malonyl-Coenzyme A and the Control of Fatty Acid Synthesis in Vivo

1972 • 182 citations

Regulation of Fatty Acid Synthesis in Isolated Hepatocytes

1973 • 156 citations

Recently discovered systems of enzyme regulation by reversible phosphorylation

1980 • 156 citations

Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge.

1980 • 149 citations

Regulation of hepatic acetyl coenzyme A carboxylase by insulin and glucagon.

1979 • 147 citations

Acetyl Coenzyme A Carboxylase* *The investigations cited in this review and unpublished studies carried out in the authors' laboratory were supported in part by research grants AM-14574 and AM-14575, United States Public Health Service and a research grant from the American Heart Association, Inc.

1974 • 136 citations

Inhibition of Rat-Liver Acetyl-Coenzyme-A Carboxylase by Palmitoyl-Coenzyme A. Formation of Equimolar Enzyme-Inhibitor Complex

1978 • 126 citations

Opposite Effects of Insulin and Glucagon in Acute Hormonal Control of Hepatic Lipogenesis

1979 • 121 citations

Reversible Phosphorylation and Inactivation of Acetyl‐CoA Carboxylase from Lactating Rat Mammary Gland by Cyclic AMP‐Dependent Protein Kinase

1980 • 111 citations

Short‐term effects of insulin and glucagon on lipid synthesis in isolated rat hepatocytes

1978 • 106 citations

Glucagon regulation of protein phosphorylation. Identification of acetyl coenzyme A carboxylase as a substrate.

1979 • 104 citations

Acetyl Coenzyme A Carboxylase from Rat Liver

1972 • 102 citations

Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis.

1977 • 99 citations

Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase

1984 • 95 citations

LIVER ACETYL COA CARBOXYLASE: THE DISSOCIATION-REASSOCIATION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY

1966 • 89 citations

Stimulation of site-specific phosphorylation of acetyl coenzyme A carboxylase by insulin and epinephrine.

1983 • 87 citations

Acetyl-CoA carboxylase. Evidence for polymeric filament to protomer transition in the intact avian liver cell.

1978 • 85 citations

Mechanism for acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in the liver cell.

1977 • 84 citations

Activation of acetyl-CoA carboxylase. Purification and properties of a Mn2+-dependent phosphatase.

1985 • 84 citations

Inhibition of Rat Liver Acetyl Coenzyme A Carboxylase by N6,O2′-Dibutyryl Cyclic Adenosine 3′:5′-Monophosphate in Vitro

1973 • 83 citations

Effect of Insulin on Fatty Acid Synthesis from Pyuvate, Lactate, or Endogenous Sources in Adipose Tissue: Evidence for the Hormonal Regulation of Pyruvate Dehydrogenase¹

1970 • 82 citations

SOME OBSERVATIONS ON A CELL FREE LIPID SYNTHESIZING SYSTEM FROM SACCHAROMYCES CEREVISIAE

1957 • 81 citations

Regulation of Acetyl-CoA Carboxylase

1983 • 81 citations

Kinetics of activation of acetyl-CoA carboxylase by citrate. Relationship to the rate of polymerization of the enzyme.

1983 • 76 citations

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

1985 • 76 citations

In vitro phosphorylation and inactivation of rat liver acetyl-CoA carboxylase purified by avidin affinity chromatography

1982 • 75 citations

The regulation of fatty acid biosynthesis

1978 • 73 citations

The Protein Phosphatases Involved in Cellular Regulation. 3. Fatty Acid Synthesis, Cholesterol Synthesis and Glycolysis/Gluconeogenesis

1983 • 69 citations

2 Acyl-CoA Carboxylases

1972 • 65 citations

Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase.

1982 • 64 citations

Acetyl Coenzyme A Carboxylase

1972 • 64 citations

Fatty acid biosynthesis

1966 • 61 citations

REQUIREMENT FOR BICARBONATE IN FATTY ACID SYNTHESIS¹

1958 • 59 citations

The polymerization of acetyl-CoA carboxylase.

1983 • 59 citations

Dephosphorylation and activation of Acetyl‐CoA‐carboxylase from lactating rabbit mammary gland

1979 • 59 citations

Reevaluation of properties of acetyl-CoA carboxylase from rat liver.

1981 • 58 citations

Purification and Physicochemical Properties of Fatty Acid Synthetase and Acetyl‐CoA Carboxylase from Lactating Rabbit Mammary Gland

1978 • 56 citations

Regulation of rat liver acetyl-CoA carboxylase. Stimulation of phosphorylation and subsequent inactivation of liver acetyl-CoA carboxylase by cyclic 3‘:5‘-monophosphate and effect on the structure of the enzyme.

1978 • 56 citations

Acetyl coenzyme A carboxylase. Rapid purification of the chick liver enzyme and steady state kinetic analysis of the carboxylase-catalyzed reaction.

1982 • 55 citations

Levels of acetyl coenzyme A carboxylase and its effectors in rat liver after short‐term fat‐free refeeding

1973 • 54 citations

Stimulation by epinephrine of in vivo phosphorylation and inactivation of acetyl coenzyme A carboxylase of rat epididymal adipose tissue.

1979 • 54 citations

Regulation of acetyl‐CoA carboxylase: identity of sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP‐dependent protein kinase

1980 • 50 citations

Inactivation of hepatic acetyl-CoA carboxylase by catecholamine and its agonists through the alpha-adrenergic receptors.

1981 • 48 citations

Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation.

1979 • 47 citations

Purification and subunit structure of rat mammary gland acetyl coenzyme A carboxylase.

1978 • 47 citations

Short-term dietary regulation of lipogenesis in the lactating mammary gland of the rat

1983 • 47 citations

Opposite effects of insulin and glucagon in acute hormonal control of hepatic lipogenesis

1979 • 45 citations

Magnetic resonance studies of the proximity and spatial arrangement of propionyl coenzyme A and pyruvate on a biotin-metalloenzyme, transcarboxylase

1976 • 43 citations

Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity

1984 • 43 citations

Regulation of Fatty Acid Synthesis in the Liver of Prenatal and Early Postnatal Chicks

1973 • 42 citations

Multiple phosphorylation of acetyl-CoA carboxylase in chick liver cells. A cyclic AMP-independent process

1978 • 40 citations

Are carboxylations involving biotin concerted or nonconcerted?

1980 • 40 citations

Purification and properties of acetyl-CoA carboxylase phosphatase.

1981 • 39 citations

Evidence for phosphorylation and activation of acetyl CoA carboxylase by a membrane‐associated cyclic AMP‐independent protein kinase

1981 • 34 citations

Pyruvate Carboxylase

1984 • 33 citations

Effect of epinephrine on acetyl-CoA carboxylase in rat epididymal fat tissue.

1978 • 33 citations

Effects of starvation, insulin or prolactin deficiency on the activity of acetyl‐CoA carboxylase in mammary gland and liver of lactating rats

1982 • 31 citations

A new method for the isolation of rat liver acetyl-CoA carboxylase.

1981 • 30 citations

Hormonal Regulation of Acetyl-CoA Carboxylase Activity in the Liver Cel

1979 • 29 citations

Acetyl Coenzyme A Carboxylase

1974 • 27 citations

Carboxybiotin translocation mechanisms suggested by diffraction studies of biotin and its vitamers.

1980 • 26 citations

Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase.

1980 • 26 citations

Internalization of insulin and its receptor in the isolated rat adipose cell

1984 • 25 citations

Regulation of mammalian acetyl‐CoA carboxylase

1981 • 23 citations

Chapter 1 Acetyl-coenzyme A carboxylase and its regulation

1984 • 21 citations

The role of phosphorylation in the regulation of fatty acid synthesis by insulin and other hormones

1983 • 20 citations

Subunit size and paracrystal structure of avian liver acetyl-CoA carboxylase

1978 • 18 citations

1 Structure and Mechanism of Fatty Acid Synthetase

1983 • 18 citations

5-Aminolaevulinate dehydratase: Zinc-65 binding and exchange with the enzyme from human erythrocytes

1981 • 18 citations

Mechanism of glucagon inhibition of liver acetyl-CoA carboxylase. Interrelationship of the effects of phosphorylation, polymer-protomer transition, and citrate on enzyme activity.

1985 • 18 citations

Regulation of acetyl-CoA carboxylase by guanine nucleotides.

1981 • 18 citations

Microsomal acetyl-CoA carboxylase: evidence for association of enzyme polymer with liver microsomes.

1981 • 17 citations

Phosphatidylinositol as essential constituent of the acetyl-CoA carboxylase from rat liver

1977 • 13 citations

Mechanisms of optic disc swelling with diffuse choroidal melanomas: clinicopathologic correlations.

1982 • 12 citations

Hormonal regulation of acetyl-CoA carboxylase in epididymal adipose tissue

1981 • 8 citations

Effects of Fluoroacetate and (—)-Hydroxycitrate on Fatty Acid Synthesis in Rat Epididymal Adipose Tissue

1977 • 6 citations

Mechanisms involved in the short-term regulation of acetyl-CoA carboxylase by insulin

1986 • 4 citations

Insulin-activated acetyl-CoA carboxylase kinase in Triton extracts of human placenta membranes

1985 • 3 citations