Internalization of insulin and its receptor in the isolated rat adipose cell

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

1981 • 456 citations

Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions

1983 • 432 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.

1975 • 203 citations

On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.

1981 • 198 citations

Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps.

1981 • 187 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

1979 • 174 citations

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL

1970 • 173 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Monensin inhibits intracellular dissociation of asialoglycoproteins from their receptor.

1983 • 157 citations

A simple, rapid, and sensitive method for measuring protein concentration in subcellular membrane fractions prepared by sucrose density ultracentrifugation

1982 • 142 citations

Intracellular polypeptide hormone receptors. Characterization of insulin binding sites in Golgi fractions from the liver of female rats.

1978 • 123 citations

Mechanism of Insulin-resistant Glucose Transport Activity in the Enlarged Adipose Cell of the Aged, Obese Rat

1982 • 117 citations

INSULIN BINDING TO RAT LIVER GOLGI FRACTIONS

1973 • 117 citations

Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

1980 • 116 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Subcellular distribution of enzymes determined by rapid digitonin fractionation of isolated hepatocytes

1980 • 96 citations

Evidence for different pathways for the degradation of insulin and insulin receptor in the chick liver cell.

1982 • 93 citations

Ligand-induced translocation of insulin receptors in intact rat liver.

1982 • 85 citations

Insulin receptors of cultured human lymphocytes (IM-9). Lack of receptor-mediated degradation.

1980 • 67 citations

Insulin binding leads to the formation of covalent (-S-S-) hormone receptor complexes.

1982 • 64 citations

Receptor‐mediated internalisation of insulin in intact rat liver

1979 • 57 citations

Effects of temperature on basal and insulin-stimulated glucose transport activities in fat cells. Further support for the translocation hypothesis of insulin action.

1982 • 55 citations

Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin.

1983 • 46 citations

Tris(hydroxmethyl)aminomethane permits the expression of insulin-induced receptor loss in isolated rat adipocytes

1981 • 32 citations

The binding of 125I-insulin to specific receptors in IM-9 human lymphocytes. Detection of radioactivity covalently linked to receptors.

1981 • 31 citations

Rapid down regulation of insulin receptors in adipocytes artifact of the incubation buffer

1981 • 29 citations

Localization of [125I]-insulin in subcellular particles of perfused rat liver

1980 • 18 citations

Metformin reduces post prandial insulin needs in type 1 diabetics assessment by the artificial pancreas

1981 • 7 citations

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