The human C_Kgene segment and the kappa deleting element are closely linked

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

Lambda replacement vectors carrying polylinker sequences

1983 • 1,809 citations

Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.

1968 • 833 citations

CYTOLOGY OF BURKITT'S TUMOUR (AFRICAN LYMPHOMA)

1964 • 627 citations

An EBV-Genome-Negative Cell Line Established from an American Burkitt Lymphoma; Receptor Characteristics. EBV Infectibility and Permanent Conversion into EBV-Positive Sublines by <i>in vitro</i> Infection

1975 • 434 citations

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

1980 • 402 citations

Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells

1981 • 332 citations

Production of Free Light Chains of Immunoglobulin by a Hematopoietic Cell Line Derived from a Patient with Multiple Myeloma.

1967 • 294 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

A uniform deleting element mediates the loss of κ genes in human B cells

1985 • 259 citations

A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events

1980 • 158 citations

Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes

1984 • 157 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

Normal human B cells display ordered light chain gene rearrangements and deletions.

1982 • 124 citations

Cytogenetic Study of Human Lymphoid T -Cell Lines Derived From Lymphocytic Leukemia 2

1974 • 116 citations

DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.

1982 • 113 citations

Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

1984 • 110 citations

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

1985 • 109 citations

Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining.

1985 • 99 citations

Origin of Immune Diversity: Genetic Variation and Selection

1985 • 99 citations

Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement.

1985 • 73 citations

Contribution of human VκII germ-line genes to light-chain diversity

1984 • 65 citations

Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation.

1985 • 63 citations

Immunoglobulin genes of thexlight chain type from two human lymphoid cell lines are closely related

1984 • 39 citations

Nonproductive Kappa Immunoglobulin Genes: Recombinational Abnormalities and Other Lesions Affecting Transcription, RNA Processing, Turnover, and Translation

1985 • 29 citations

Cloning and sequencing of a rearranged V_λgene from a Burkitt's tymphoma cell line expressing kappa light chains

1985 • 27 citations

Correlation between DNase I hypersensitive sites and putative regulatory sequences in human immunoglobulin genes of thexlight chain type

1984 • 21 citations