The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Multiple receptors for dopamine

1979 • 3,739 citations

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

The organization of the projection from the cerebral cortex to the striatum in the rat

1989 • 1,334 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.

1979 • 1,184 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Basal Ganglia and Limbic System Pathology in Schizophrenia

1985 • 891 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Advances in Biochemical Psychopharmacology

1970 • 760 citations

An Anatomy of Schizophrenia?

1973 • 721 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Psychiatric Aspects of Neurologic Disease

1976 • 674 citations

ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA

1974 • 673 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Release of dopamine from dendrites in rat substantia nigra

1976 • 644 citations

On the Presence of 3-Hydroxytyramine in Brain

1958 • 632 citations

In Vivo Measurement of Dopamine and Its Metabolites by Intracerebral Dialysis: Changes After d‐Amphetamine

1983 • 615 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

1990 • 597 citations

Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

1973 • 590 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Significance of Neuroleptic Dose and Plasma Level in the Pharmacological Treatment of Psychoses

1988 • 554 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies

1977 • 544 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1970 • 534 citations

Overview: toward a dysregulation hypothesis of depression

1985 • 519 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists

1979 • 502 citations

The chemical excitation of spinal neurones by certain acidic amino acids

1960 • 484 citations

Phencyclidine-induced psychosis

1978 • 482 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Catecholamines: Basic and clinical frontiers

1981 • 458 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system

1989 • 435 citations

Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons

1989 • 434 citations

Amphetamine Psychosis

1957 • 429 citations

Catecholamines in the Brain as Mediators of Amphetamine Psychosis

1972 • 428 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

Biochemical and Histochemical Studies on the Effects of Imipramine‐like Drugs and (+)‐Amphetamine on Central and Peripheral Catecholamine Neurons

1966 • 414 citations

The Mechanism of Action of Novel Antipsychotic Drugs

1991 • 410 citations

Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons

1979 • 393 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

The neurochemistry of Parkinson's disease: effect of L-dopa therapy.

1975 • 386 citations

In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs implications for the origin of extracellular DOPAC

1988 • 378 citations

Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia

1985 • 373 citations

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.

1965 • 348 citations

Differential effects of amphetamine and neuroleptics on negative Vs. positive symptoms in schizophrenia

1980 • 347 citations

Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum

1976 • 343 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases

1987 • 322 citations

D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics

1989 • 322 citations

Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients

1986 • 318 citations

Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis

1985 • 314 citations

Psychopharmacology: A Generation of Progress

1978 • 310 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine.

1966 • 307 citations

In vivo presynaptic control of dopamine release in the cat caudate nucleus—II. Facilitatory or inhibitory influence ofl-glutamate

1986 • 290 citations

An Analysis of the Arrangement of Neurons in the Cingulate Cortex of Schizophrenic Patients

1987 • 280 citations

Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity

1985 • 279 citations

An In Vivo Study of Dopamine Release and Metabolism in Rat Brain Regions Using Intracerebral Dialysis

1986 • 261 citations

Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats

1990 • 260 citations

Psychiatric Aspects of Neurologic Disease

1985 • 254 citations

Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

1973 • 251 citations

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

1989 • 250 citations

Dopamine release in substantia nigra?

1976 • 249 citations

Prevalence Studies in Schizophrenia

1987 • 247 citations

Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis

1984 • 247 citations

Neuroleptic-Induced Decrease in Plasma Homovanillic Acid and Antipsychotic Activity in Schizophrenic Patients

1984 • 244 citations

Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen.

1989 • 242 citations

[Therapeutic use in psychiatry of phenothiazine of central elective action (4560 RP)].

1952 • 240 citations

Hippocampal Pyramidal Cell Disarray in Schizophrenia as a Bilateral Phenomenon

1991 • 239 citations

Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence

1980 • 239 citations

Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia.

1987 • 238 citations

Differential effects of D- and L-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain

1971 • 235 citations

Schizophrenic Symptoms Improve with Apomorphine

1978 • 228 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates

1983 • 227 citations

Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.

1977 • 222 citations

Biological Psychiatry

1986 • 218 citations

Quantification of the dopamine innervation in adult rat neostriatum

1986 • 216 citations

Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat

1983 • 212 citations

Dopamine Synaptic Mechanisms Reflected in Studies Combining Behavioural Recordings and Brain Dialysis

1982 • 210 citations

Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.

1989 • 208 citations

Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics

1988 • 205 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—3. Evidence for electrotonic coupling

1983 • 204 citations

Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia

1975 • 202 citations

Release of dopamine evoked by electrical stimulation of the motor and visual areas of the cerebral cortex in both caudate nuclei and in the substantia nigra in the cat

1978 • 202 citations

Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: Evidence for its mediation by quisqualateor kainate-receptors

1985 • 201 citations

Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia

1983 • 201 citations

Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons

1985 • 196 citations

Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis.

1981 • 194 citations

The role of dopamine in intracranial self-stimulation of the ventral tegmental area

1987 • 189 citations

Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: Differences between normal controls and schizophrenic patients

1987 • 185 citations

Imaging of Neurotransmitter Receptors in the Living Human Brain

1986 • 182 citations

The glutamate-mediated release of dopamine in the rat striatum: Further characterization of the dual excitatory-inhibitory function

1990 • 179 citations

Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies

1990 • 176 citations

EFFECTS OF DRUGS ON AVOIDANCE AND ESCAPE BEHAVIOR.

1964 • 163 citations

Feedback loop or output pathway in striato-nigral fibres?

1977 • 160 citations

Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum.

1976 • 160 citations

Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy

1986 • 159 citations

Schizophrenia—A Follow-up Study of Results of Treatment

1976 • 158 citations

[A new vegetative stabilizer; 4560 R.P..].

1952 • 157 citations

Special antagonism of amphetamine-induced abnormal behaviour

1965 • 156 citations

Evidence of glutamatergic deficiency in schizophrenia

1991 • 154 citations

Detecting behaviorally relevant changes in extracellular dopamine with microdialysis

1987 • 150 citations

Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons.

1977 • 149 citations

Real-time measurement of dopamine release in rat brain

1986 • 148 citations

Plasma catecholamine metabolites and early response to haloperidol.

1984 • 146 citations

The Effect of Neuroleptics and Other Psychotropic Drugs on Negative Symptoms in Schizophrenia

1986 • 143 citations

Monitoring the Stimulated Release of Dopamine with In Vivo Voltammetry. I: Characterization of the Response Observed in the Caudate Nucleus of the Rat

1984 • 143 citations

Differentiation of Dopamine Overflow and Uptake Processes in the Extracellular Fluid of the Rat Caudate Nucleus with Fast-Scan In Vivo Voltammetry

1988 • 129 citations

Amino Acids in Rat Striatal Dialysates: Methodological Aspects and Changes After Electroconvulsive Shock

1985 • 126 citations

Comparative Psychotomimetic Effects of Stereoisomers of Amphetamine

1971 • 125 citations

Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy

1983 • 125 citations

Autoradiographic localization of D1 and D2 dopamine receptors in the human brain

1988 • 124 citations

Kritische Stellungnahme zum Begriff der Neuroleptika

1971 • 122 citations

Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: Correlations to symptomatology and family history

1985 • 121 citations

Aminergic Systems in Basal Ganglia Associated with Stereotyped Hyperactive Behavior and Catalepsy

1968 • 116 citations

Stress‐induced neurological impairments in an animal model of parkinsonism

1985 • 115 citations

Supersensitivity in rat caudate nucleus: Effects of 6-hydroxydopamine on the time course of dopamine receptor and cyclic AMP changes

1980 • 113 citations

Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction

1982 • 112 citations

Extracellular Events Induced by γ‐Hydroxybutyrate in Striatum: A Microdialysis Study

1991 • 112 citations

Psychopharmacological effects of low and high doses of apomorphine during ontogeny

1980 • 112 citations

The effect of l-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs

1975 • 111 citations

Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones

1982 • 111 citations

Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra

1980 • 110 citations

Substantia nigra dopaminergic unit activity in behaving cats: Effect of arousal on spontaneous discharge and sensory evoked activity

1985 • 109 citations

Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.

1985 • 109 citations

Haloperidol increases and apomorphine decreases striatal dopamine metabolism after destruction of striatal dopamine-sensitive adenylate cyclase by kainic acid

1977 • 104 citations

Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology

1985 • 101 citations

Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo

1987 • 99 citations

5-Hydroxyindoleacetic acid (5 HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines

1973 • 98 citations

Cerebroventricular size and cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy volunteers

1983 • 96 citations

Monitoring the Stimulated Release of Dopamine with In Vivo Voltammetry. II: Clearance of Released Dopamine from Extracellular Fluid

1984 • 95 citations

Compensatory responses to nigrostriatal bundle injury

1989 • 95 citations

Reversal of two manifestations of dopamine receptor supersensitivity by administration of L-dopa.

1977 • 92 citations

Effect of dopamine agonists and antagonists on the electrical activity of substantia nigra neurons transplanted into the lateral ventricle of the rat

1981 • 91 citations

Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons

1989 • 91 citations

Naloxone overcomes the dopaminergic, EEG, and behavioral effects of γ‐hydroxybutyrahe

1980 • 86 citations

Long-term effects of dopamine-depleting brain lesions on spontaneous activity of type II striatal neurons: Relation to behavioral recovery

1986 • 85 citations

Differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in rats

1976 • 83 citations

Effects of electrical stimulation of brain reward sites on release of dopamine in rat: An in vivo electrochemical study

1988 • 83 citations

Presynaptic regulation of dopaminergic transmission in the striatum

1988 • 81 citations

Presynaptic dopamine receptors. Development of supersensitivity following treatment with fluphenazine decanoate.

1977 • 80 citations

Notes from the graveyard: neuropathology and schizophrenia*

1990 • 77 citations

Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers

1988 • 73 citations

Amantadine versus trihexyphenidyl in the treatment of neuroleptic- induced parkinsonism

1976 • 71 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1969 • 70 citations

Glutamate Receptors of a Quisqualate‐Kainate Subtype are Involved in the Presynaptic Regulation of Dopamine Release in the Cat Caudate Nucleus in vivo

1990 • 70 citations

Presynaptic modulation of the release of GABA by GABAA receptors in pars compacta and by GABAB receptors in pars reticulata of the rat substantia nigra

1988 • 69 citations

Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.

1991 • 69 citations

Do endogenous excitatory amino acids influence striatal dopamine release?

1991 • 69 citations

Tardive dyskinesia associated with metoclopramide.

1978 • 68 citations

Chronic haloperidol decreases dopamine release in striatum and nucleus accumbens in vivo: Depolarization block as a possible mechanism of action

1987 • 66 citations

Effect of extracellular dopamine on the release of dopamine in the rabbit caudate nucleus: Evidence for a dopaminergic feedback inhibition

1979 • 66 citations

Experimental neurological syndromes and thenew drug therapies in psychiatry

1960 • 61 citations

Environmental stress increases extracellular dopamine in striatum of 6-hydroxydopamine-treated rats: in vivo microdialysis studies

1990 • 60 citations

Further studies on the antagonism of stereotyped behaviour induced by amphetamine

1969 • 58 citations

Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats

1988 • 58 citations

Neurotransmitters and depression Too much, too little, or too unstable?

1979 • 57 citations

Responses of substantia nigra pars reticulata neurons to GABA and SKF 38393 in 6-hydroxydopamine-lesioned rats are differentially affected by continuous and intermittent levodopa administration

1990 • 56 citations

Presynaptic dopamine receptors: Insensitivity to kainic acid and the development of supersensitivity following chronic haloperidol

1980 • 56 citations

Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons

1992 • 54 citations

In vivo presynaptic control of dopamine release in the cat caudate nucleus—I. Opposite changes in neuronal activity and release evoked from thalamic motor nuclei

1986 • 52 citations

Responses of rat substantia nigra compacta neurones to L‐DOPA

1990 • 49 citations

Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: Further evidence for depolarization block

1991 • 49 citations

Plasma catecholamine metabolites and treatment response at neuroleptic steady state

1989 • 48 citations

The effect of uptake inhibition on dopamine release from the nucleus accumbens of rats during self- or forced stimulation of the medial forebrain bundle: A microdialysis study

1989 • 48 citations

The need for continuous use of antiparkinsonian medication with chronic schizophrenic patients receiving long-term neuroleptic therapy

1981 • 47 citations

GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB

1990 • 46 citations

The GABAB antagonist, CGP 35348, antagonizes the effects of baclofen, ?-butyrolactone and HA 966 on rat striatal dopamine synthesis

1991 • 46 citations

Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum

1980 • 46 citations

The effect of neuroleptic discontinuation on psychopathology, involuntary movements, and biochemical measures in patients with persistent tardive dyskinesia

1989 • 45 citations

Amphetamine attenuates the stimulated release of dopamine in vivo.

1985 • 44 citations

Anomalously High Concentrations of Brain Extracellular Uric Acid Detected with Chronically Implanted Probes: Implications for In Vivo Sampling Techniques

1991 • 42 citations

Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions

1989 • 41 citations

Psychosis and the temporal lobe.

1991 • 41 citations

Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats

1990 • 40 citations

Clinical Pharmacology in Psychiatry: Neuroleptic and Antidepressant Research

1981 • 39 citations

Brain dialysis and dopamine: does the extracellular concentration of dopamine reflect synaptic release?

1990 • 39 citations

Behavioral evidence for midbrain dopamine depolarization inactivation

1989 • 39 citations

Effect of γ‐hydroxybutyrate on the release of monoamines from the rat striatum

1972 • 37 citations

The effect of l-DOPA on in vivo dopamine release from nigrostriatal bundle neurons

1988 • 36 citations

Clinical Implications of Receptor Sensitivity Modification

1983 • 35 citations

Response to Neuroleptic Drugs as a Device for Classifying Schizophrenia

1989 • 34 citations

Paradoxical reaction to L-dopa in schizophrenic patients

1978 • 32 citations

GABA in the thalamic motor nuclei modulates dopamine release from the two dopaminergic nigrostriatal pathways in the cat

1983 • 31 citations

NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens

1989 • 31 citations

Electrical stimulation of the midbrain central gray facilitates lateral vestibulospinal activation of back muscle EMG in the rat

1987 • 30 citations

Tolerance to tyrosine hydroxylase activation in N. Accumbens and C. Striatum after repeated injections of “classical” and “atypical” antischizophrenic drugs

1978 • 28 citations

Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment

1980 • 27 citations

GABAergic supersensitivity within the pars reticulata of the rat substantia nigra following chronic haloperidol administration

1987 • 26 citations

Partial dopamine depletions result in an enhanced sensitivity of residual dopamine neurons to apomorphine

1991 • 25 citations

Effect of gamma-hydroxybutyrate and gamma-butyrolactone on dopamine synthesis and uptake by rat striatum

1972 • 25 citations

A quantitative description of excitatory amino acid neurotransmitter responses on cultured embryonic Xenopus spinal neurons

1989 • 24 citations

Review on neuroleptic receptors: specificity and multiplicity of in vitro binding related to pharmacological activity

1981 • 24 citations

Does treatment with haloperidol for 3 weeks produce depolarization block in midbrain dopamine neurons of unanaesthetized rats?

1988 • 22 citations

Tolerance to haloperidol-induced increases in dopamine metabolites: fact or artifact?

1987 • 21 citations

Spontaneous activity of A9 and A10 dopamine neurons after acute and chronic administration of the selective dopamine D-1 receptor antagonist SCH 23390

1988 • 20 citations

Ontogeny of tolerance to haloperidol: Behavioral and biochemical measures

1985 • 20 citations

Effects of phencyclidine on the release and synthesis of newly formed dopamine

1983 • 19 citations

Subsensitivity of striatal and mesolimbic dopamine target cells after repeated treatment with apomorphine dipivaloyl ester

1978 • 17 citations

Chronic treatment with high doses of haloperidol fails to decrease the time course for the development of depolarization inactivation of midbrain dopamine neurons

1988 • 16 citations

Combined treatment of tardive dyskinesia with clonidine and neuroleptics: A follow-up study of three cases for three years

1983 • 15 citations

Clinical Pharmacology in Psychiatry: Neuroleptic and Antidepressant Research

1983 • 15 citations

[Systematic neuroleptic therapy with the appearance of parkinsonian states].

1956 • 14 citations

Dr. Manos Replies

1981 • 13 citations

An adverse reaction to metoclopramide therapy

1978 • 13 citations

Thérapeutique par médication neuroleptique obtenue en réalisant systématiquement des états parkinsoniformes.

1956 • 12 citations

Focal neuroleptization: an approach to optimal dosing for initial and continuing therapy.

1985 • 12 citations

CI-943, a potential antipsychotic agent. III. Evaluation of effects on dopamine neuronal activity.

1989 • 11 citations

Effect of chronic haloperidol on dopamine release following microinjection of GABA into the substantia nigra zona reticulata in the rat

1986 • 10 citations

Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine-lesioned rats.

1991 • 10 citations

Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine-lesioned rats.

1991 • 9 citations

[Neuroplegic medications and cures in psychiatry: preliminary trials with reserpine; comparison with the effects of chlorpromazine].

1955 • 7 citations

Chronic haloperidol administration increases GABA binding and enhances neuronal responsiveness to iontophoresed GABA in rat globus pallidus

1989 • 7 citations

EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY

1979 • 6 citations

Characteristics of the adaptive aspects of the dopaminergic system.

1988 • 5 citations

Deleted Work

1955 • 0 citations