Activation of CFTR chloride current by nitric oxide in human T lymphocytes.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

NO at work

1994 • 1,493 citations

A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

1959 • 1,397 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

The biology of nitrogen oxides in the airways.

1994 • 928 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

1986 • 581 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

The Cystic Fibrosis Transmembrane Conductance Regulator

1993 • 438 citations

Responses of lymphocytes to anisotonic media: volume-regulating behavior

1984 • 427 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase.

1994 • 268 citations

Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP

1992 • 265 citations

Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation.

1977 • 238 citations

Comparative effects of some nitric oxide donors on cyclic GMP levels in rat cerebellar slices

1991 • 207 citations

LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase.

1988 • 205 citations

Chloride channels activated by osmotic stress in T lymphocytes.

1993 • 204 citations

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1991 • 192 citations

CFTR!

1992 • 192 citations

Nitric oxide signaling: a possible role for G proteins.

1993 • 175 citations

A cAMP-Regulated Chloride Channel in Lymphocytes That Is Affected in Cystic Fibrosis

1989 • 163 citations

Identification and regulation of whole-cell chloride currents in airway epithelium.

1989 • 117 citations

Neurotransmitters, hormones, and cyclic nucleotides in lymphocyte regulation.

1985 • 114 citations

Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.

1993 • 112 citations

L-arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways

1993 • 104 citations

Quantitative expression patterns of multidrug‐resistance P‐glycoprotein (MDR1) and differentially spliced cystic‐fibrosis transmembrane‐conductance regulator mRNA transcripts in human epithelia

1992 • 97 citations

Cell Cycle Dependence of Chloride Permeability in Normal and Cystic Fibrosis Lymphocytes

1990 • 94 citations

Expression of cystic fibrosis transmembrane regulator Cl- channels in heart.

1992 • 87 citations

Nitric oxide generation from L-arginine is required for optimal human peripheral blood lymphocyte DNA synthesis.

1991 • 84 citations

Volume response of quiescent and interleukin 2-stimulated T-lymphocytes to hypotonicity

1988 • 75 citations

Alternative splicing of CFTR Cl- channels in heart

1993 • 74 citations

Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current.

1992 • 71 citations

Cloned murine T lymphocytes synthesize a molecule with the biological characteristics of nitric oxide

1990 • 66 citations

cGMP-dependent protein kinase regulation of a chloride channel in T84 cells

1992 • 52 citations

In vitro T cell responses in patients with cystic fibrosis and allergic bronchopulmonary aspergillosis.

1989 • 47 citations

Transfection of wild-type CFTR into cystic fibrosis lymphocytes restores chloride conductance at G1 of the cell cycle.

1992 • 45 citations

Regulation of cyclic GMP formation by soluble guanylate cyclase: stimulation by NO-containing compounds.

1984 • 42 citations

T- and B-cell dysregulation of IgE synthesis in cystic fibrosis patients with allergic bronchopulmonary aspergillosis

1990 • 41 citations

Cytolytic T lymphocyte effector function requires plasma membrane chloride flux.

1986 • 34 citations

Role of ion channels in lymphocytes

1991 • 32 citations

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes.

1988 • 30 citations

Guanyl Cyclase Activity of Human Blood Lymphocytes

1975 • 26 citations

Cyclic nucleotides in immune responses and allergy.

1980 • 24 citations

Functional immunoregulatory T-cell abnormalities in cystic fibrosis patients

1989 • 18 citations

Transmembrane chloride flux is required for target cell lysis but not for Golgi reorientation in cloned cytolytic effector cells. Golgi reorientation, N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase release, and delivery of the lethal hit are separable events in target cell lysis.

1988 • 17 citations

T Cell Cytotoxicity in Cystic Fibrosis: Relationship to Pulmonary Status

1990 • 8 citations

Guanylate Cyclase Activity of Human Lymphocytes from Peripheral Blood, Thymus, and Tonsils

1983 • 6 citations

Exogenous Modification of Nitrovasodilator‐Induced Cyclic GMP Formation in Human Lymphocytes

1992 • 5 citations