Gender Differences in Brain and Behavior

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

The Physiology of Reproduction

1988 • 3,218 citations

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

Handbook of infant development

1979 • 2,277 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Sexual Differentiation of the Central Nervous System

1981 • 1,475 citations

Handbook of Behavioral Neurobiology

2001 • 1,362 citations

Neuroactive steroids

1992 • 1,260 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors and

1997 • 1,148 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Nongenomic actions of steroid hormones

2003 • 944 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Cytokine Production and Treatment Response in Major Depressive Disorder

2000 • 725 citations

Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens

1999 • 689 citations

Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells

1977 • 686 citations

SPECIFIC, NONGENOMIC ACTIONS OF STEROID HORMONES

1997 • 663 citations

Gonadal hormones and sex differences in nonreproductive behaviors in rodents: Organizational and activational influences

1979 • 639 citations

Behavioral endocrinology

1992 • 606 citations

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

1998 • 598 citations

Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat

1980 • 584 citations

Sexual dimorphism in the neurophil of the preoptic area of the rat and its dependence on neonatal androgen

1973 • 583 citations

Sex differences in animal tests of anxiety

1991 • 576 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Ovarian steroids and the brain

1997 • 481 citations

Two sexually dimorphic cell groups in the human brain

1989 • 460 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1991 • 454 citations

The organizational effects of gonadal steroids on sexually dimorphic spatial ability

1991 • 453 citations

Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons

1992 • 449 citations

LTP varies across the estrous cycle: enhanced synaptic plasticity in proestrus rats

1995 • 430 citations

Sex differences in the corpus callosum of the living human being

1991 • 379 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells

1999 • 371 citations

The eye of the beholder: Parents' views on sex of newborns.

1974 • 365 citations

CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS¹

1942 • 348 citations

Mother rats interact differently with male amd female offspring.

1979 • 340 citations

Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats

1997 • 322 citations

The role of apoptosis in sexual differentiation of the rat sexually dimorphic nucleus of the preoptic area

1996 • 321 citations

Sexual differentiation of the brain and its experimental control.

1965 • 318 citations

Influence of social isolation, gender, strain, and prior novelty on plus-maze behaviour in mice

1993 • 302 citations

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1991 • 293 citations

Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.

1992 • 284 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.

1996 • 283 citations

Progesterone, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states

1997 • 269 citations

Effects of discrete lesions of the sexually dimorphic nucleus of the preoptic area or other medial preoptic regions on the sexual behavior of male rats

1983 • 266 citations

Variations in memory function and sex steroid hormones across the menstrual cycle

1992 • 264 citations

Gender-related differences in the antinociceptive properties of morphine.

1996 • 260 citations

Anxiolytic effect of progesterone is associated with increases in cortical alloprenanolone and GABAA receptor function

1993 • 257 citations

Neural Mechanisms of Female Reproductive Behavior

1985 • 256 citations

Factor Analysis Shows That Female Rat Behaviour Is Characterized Primarily by Activity, Male Rats Are Driven by Sex and Anxiety

1999 • 237 citations

Influence of gender and age on performance of rats in the elevated plus maze apparatus

1993 • 235 citations

Dopamine-containing neurons in the mammalian central nervous system: Electrophysiology and pharmacology

1988 • 233 citations

Sex Differences in Neurotransmitter Systems

1990 • 224 citations

Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.

1993 • 223 citations

Primary genetic control of somatic sexual differentiation in a mammal

1988 • 212 citations

Maternal contributions to the development of masculine sexual behavior in laboratory rats

1984 • 208 citations

Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma

1990 • 204 citations

The steroid receptor superfamily: mechanisms of diversity

1991 • 202 citations

Sex differences in anxiety behavior in rats: Role of gonadal hormones

1993 • 193 citations

Neurogenesis of the sexually dimorphic nucleus of the preoptic area in the rat

1981 • 189 citations

STUDIES ON MATING BEHAVIOUR IN THE ANDROGEN-STERILIZED FEMALE RAT IN RELATION TO THE HYPOTHALAMIC REGULATION OF SEXUAL BEHAVIOUR

1962 • 188 citations

Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore

1988 • 187 citations

Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect

1989 • 185 citations

Sex differences in rat brain oestrogen and progestin receptors

1982 • 184 citations

Sex differences in “cognitive” regions of the rat brain

1991 • 183 citations

Female sex steroid hormones: from receptors to networks to performance—actions on the sensorimotor system

1994 • 180 citations

Male-Female Difference in Synaptic Organization of the Ventromedial Nucleus of the Hypothalamus in the Rat

1986 • 177 citations

Androgen Receptor in Mouse Brain: Sex Differences and Similarities in Autoregulation¹

1998 • 172 citations

Transcriptional Effects of Estrogen on Neuronal Neurotensin Gene Expression Involve cAMP/Protein Kinase A-Dependent Signaling Mechanisms

1998 • 171 citations

Estradiol selectively regulates agonist binding sites on the N-methyl-D- aspartate receptor complex in the CA1 region of the hippocampus

1992 • 169 citations

Sex differences in opioid antinociception.

1997 • 166 citations

The Neurosteroid, 3α‐Hydroxy‐5α‐pregnan‐20‐one, Protects against Bicuculline‐Induced Seizures during Ethanol Withdrawal in Rats

1995 • 161 citations

Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons

1992 • 154 citations

The Estrogen/Neurotrophin Connection during Neural Development: Is Co-Localization of Estrogen Receptors with the Neurotrophins and Their Receptors Biologically Relevant?

1996 • 154 citations

Developmental regulation of sex differences in the brain: Can the role of gonadal steroids be redefined?

1994 • 152 citations

Glutamic acid decarboxylase messenger ribonucleic acid is regulated by estradiol and progesterone in the hippocampus.

1992 • 152 citations

The Human Cerebral Cortex: Gender Differences in Structure and Function

1999 • 151 citations

The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid.

1994 • 146 citations

Estrogen suppresses mu-opioid- and GABAB-mediated hyperpolarization of hypothalamic arcuate neurons

1992 • 139 citations

Gender, Sex Steroids, Corticotropin-Releasing Factor, Nitric Oxide, and the HPA Response to Stress

1999 • 139 citations

Membrane Sex-Steroid Receptors in the Brain

1996 • 137 citations

Primate brain evolution : genetic and functional considerations

1996 • 137 citations

Sex Difference in Estradiol Regulation of Progestin Receptor mRNA in Rat Mediobasal Hypothalamus as Demonstrated by in situ Hybridization

1991 • 136 citations

Nongenomic Actions of Estrogen in the Brain: Physiological Significance and Cellular Mechanisms

1996 • 129 citations

Patients with Premenstrual Syndrome Have Reduced Sensitivity to Midazolam Compared to Control Subjects

1997 • 128 citations

Influence of oestrogen on spontaneous and diazepam-induced exploration of rats in an elevated plus maze

1988 • 121 citations

Electrophysiological evidence for a rapid membrane action of the gonadal steroid, 17β-estradiol, on CA1 pyramidal neurons of the rat hippocampus

1991 • 120 citations

Critical Role for the Medial Preoptic Area in the Sexual Differentiation of the Brain

1984 • 115 citations

Gender difference in hypothalamic–pituitary–adrenal axis response to alcohol in the rat: activational role of gonadal steroids

1997 • 115 citations

Hormonal control of neuropeptide gene expression in sexually dimorphic olfactory pathways

1990 • 114 citations

Drug discrimination analysis of endogenous neuroactive steroids in rats

1993 • 114 citations

Sex Differences in the Activational Effect of ERα on Spatial Learning

1998 • 113 citations

Ontogeny of Region-Specific Sex Differences in Androgen Receptor Messenger Ribonucleic Acid Expression in the Rat Forebrain*

1998 • 112 citations

The Father's Role in Infancy: A Re-Evaluation

1976 • 111 citations

Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum

1987 • 111 citations

Sex differences in sensitivity of food intake, body weight, and running-wheel activity to ovarian steroids in rats.

1976 • 111 citations

Diazepam Kinetics in Relation to Age and Sex

1981 • 109 citations

Ovarian endocrine status modulates the anxiolytic potency of diazepam and the efficacy of !g-aminobutyric acid-benzodiazepine receptor-mediated chloride ion transport.

1991 • 109 citations

A specific membrane binding protein for progesterone in rat brain: sex differences and induction by estrogen.

1993 • 107 citations

Specific subunit mRNAs of the GABAA receptor are regulated by progesterone in subfields of the hippocampus

1995 • 106 citations

Gonadal and adrenal steroids regulate neurochemical and structural plasticity of the hippocampus via cellular mechanisms involving NMDA receptors

1996 • 105 citations

Sex difference in mouse embryonic development at neurulation

1987 • 105 citations

Lack of Prenatal Testosterone Surge in Fetal Rats Exposed to Alcohol: Alterations in Testicular Morphology and Physiology

1988 • 98 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain

1996 • 93 citations

Raloxifene Induces Neurite Outgrowth in, Estrogen Receptor Positive PC 12 Cells

1998 • 92 citations

Ovarian endocrine status modulates the anxiolytic potency of diazepam and the efficacy of !g-aminobutyric acid-benzodiazepine receptor-mediated chloride ion transport.

1991 • 92 citations

Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus.

1995 • 92 citations

Neurosteroids: biosynthesis and function.

1995 • 90 citations

Sex and Genotype Determine the Selective Activation of Neurochemically-Distinct Mechanisms of Swim Stress-Induced Analgesia

1997 • 90 citations

Estrogen-induction of dendritic spines in ventromedial hypothalamus and hippocampus: effects of neonatal aromatase blockade and adult GDX

1995 • 88 citations

Sex-dependent effects of aversive stimulation on holeboard and elevated plus-maze behavior

1991 • 87 citations

Social play in juvenile rats prenatally exposed to alcohol

1986 • 86 citations

Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense Test Battery

1992 • 83 citations

Regional sex differences in progestin receptor induction in the rat hypothalamus: effects of various doses of estradiol benzoate.

1987 • 82 citations

Immunocytochemical analysis of sex differences in calcitonin gene-related peptide in the rat dorsal root ganglion, with special reference to estrogen and its receptor

1998 • 81 citations

Maternal stimulation affects the number of motor neurons in a sexually dimorphic nucleus of the lumbar spinal cord

1992 • 79 citations

Sex Hormone Modulation of Neural Development in Vitro

1994 • 79 citations

The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.

1993 • 76 citations

GABA Physiology: Modulation by Benzodiazepines and Hormones

1996 • 76 citations

Gender Impacts Behavioral and Neurochemical Adaptations in Ethanol-Dependent Rats

1999 • 75 citations

Androgen effects on cognition: Congenital adrenal hyperplasia

1991 • 73 citations

Withdrawal from the endogenous steroid progesterone results in GABAA currents insensitive to benzodiazepine modulation in rat CA1 hippocampus

1995 • 71 citations

Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity

1998 • 70 citations

Estrogenic regulation and sex dimorphism of growth-associated protein 43 kDa (GAP-43) messenger RNA in the rat

1991 • 69 citations

Sexually Dimorphic Expression of Androgen Receptor Immunoreactivity by Somatostatin Neurones in Rat Hypothalamic Periventricular Nucleus and Bed Nucleus of the Stria Terminalis

1995 • 69 citations

Neuroactive Steroid Modulators of the Stress Response

1995 • 68 citations

Androgen Receptor in Mouse Brain: Sex Differences and Similarities in Autoregulation

1998 • 66 citations

Glutamic acid decarboxylase messenger ribonucleic acid is regulated by estradiol and progesterone in the hippocampus

1992 • 66 citations

Prenatal Exposure to Low Doses of the Estrogenic Chemicals Diethylstilbestrol and o,p′-DDT Alters Aggressive Behavior of Male and Female House Mice

1999 • 62 citations

3α-OH-DHP and 5α-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus

1993 • 61 citations

The oxytocin receptor: a target for steroid hormones

1993 • 60 citations

Behavioural responses to single and repeated restraint in male and female rats

1992 • 59 citations

Sex difference in dendritic development of the sexually dimorphic nucleus of the preoptic area in the rat

1984 • 58 citations

Sexually dimorphic effects of perinatal alcohol exposure on social interactions and amygdala DNA and DOPAC concentrations

1994 • 57 citations

Dehydroepiandrosterone sulfate alters synaptic potentials in area CA1 of the hippocampal slice

1994 • 57 citations

Perinatal Substance Abuse

1992 • 55 citations

Chronic anabolic-androgenic steroid treatment affects brain gabaa receptor-gated chloride ion transport

1996 • 53 citations

Sex and the developing brain: suppression of neuronal estrogen sensitivity by developmental androgen exposure.

1997 • 50 citations

Genetic Influences on Sexual Behavior Differentiation

1992 • 50 citations

Sex differences of hypothalamic prolactin cells develop independently of the presence of sex steroids

1992 • 50 citations

Steroid Regulation and Sex Differences in [³H]Muscimol Binding in Hippocampus, Hypothalamus and Midbrain in Rats

1992 • 47 citations

Evidence that 5α-pregnan-3α-ol-20-one is the metabolite responsible for progesterone anesthesia

1990 • 46 citations

Anxiolytic actions of diazepam, but not of buspirone, are influenced by gender and the endocrine stage

1997 • 45 citations

Regional distribution of progesterone and 5α-pregnane-3,20-dione in rat brain during progesterone-induced “anesthesia”

1990 • 42 citations

Prodynorphin and proenkephalin gene expression in the anteroventral periventricular nucleus of the rat: Sexual differentiation and hormonal regulation

1991 • 42 citations

Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats

1994 • 39 citations

Alternatives in child rearing in the 1970s.

1973 • 39 citations

Steroid Hormones and Receptors of the GABA<sub>A</sub> Supramolecular Complex

1993 • 38 citations

Metabolism of dihydrotestosterone to 3α-androstanediol in brain and plasma: effect on behavioural activity in female rats

1992 • 36 citations

Sex-Dependent Behavioral Effects of the Neurosteroid Allopregnanolone (3α,5α-THP) in Neonatal and Adult Rats after Postnatal Stress

1999 • 33 citations

Ontogeny of Region-Specific Sex Differences in Androgen Receptor Messenger Ribonucleic Acid Expression in the Rat Forebrain

1998 • 32 citations

Gonadal Steroids and Neuronal Plasticity

1994 • 31 citations

Sex Differences in Long-Term Consequences of Prenatal Diazepam Exposure

1999 • 28 citations

Sex Differences in Cytosolic Androgen Receptors in Gonadectomized Male and Female Rats

1996 • 27 citations

Chronic estrogen effects on 5-hydroxytryptamine-mediated responses in hippocampal pyramidal cells of female rats

1989 • 26 citations

Sex differences in estrogen receptor and progestin receptor induction in the guinea pig hypothalamus and preoptic area

1996 • 26 citations

The ontogeny of GAP‐43 (neuromodulin) mRNA in postnatal rat brain: Evidence for a sex dimorphism

1994 • 24 citations

Pregnanolone (3α-hydroxy-5α-pregnane-20-one), a progesterone metabolite, facilitates inhibition of synaptic transmission in the Schäffer collateral pathway of the guinea pig hippocampus in vitro

1991 • 24 citations

Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus

1995 • 24 citations

Nerve growth factor-mediated sexual differentiation of the rat hypothalamus

1988 • 23 citations

Acute effects of triazolam in women: relationships with progesterone, estradiol and allopregnanolone

1997 • 22 citations

Progesterone: does it affect response to drug?

1997 • 22 citations

Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid

1993 • 19 citations

Interaction between 17β‐oestradiol and 3α‐hydroxy‐5α‐pregnane‐20‐one in the control of neuronal excitability in slices from the CA1 hippocampus in vitro of guinea‐pigs and rats

1995 • 18 citations

Schedule-Induced Polydipsia

1999 • 15 citations

Pharmacokinetics of imipramine are affected by age and sex in rats

1986 • 14 citations

Maternal Sex-Stereotyping of Newborns

1994 • 13 citations

The effects of allopregnanolone, pregnenolone sulphate and pregnenolone on the CA1 population spike of the rat hippocampus after 17β‐oestradiol priming

1997 • 13 citations

Differential regulation of estrogen-dependent sexual development of rat brain by growth factors

1991 • 11 citations

Sex differences in estrogen receptor and progestin receptor induction in the guinea pig hypothalamus and preoptic area

1996 • 7 citations

Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels

1999 • 6 citations

Long-term in vivo desipramine or estrogen treatment fails to affect serotonin-induced outward current in hippocampal pyramidal cells of the rat

1994 • 5 citations

Sexually dimorphic pattern in the hypothalamic and limbic brain.

1985 • 4 citations