Sex and the developing brain: suppression of neuronal estrogen sensitivity by developmental androgen exposure.

Sexual Differentiation of the Central Nervous System

1981 • 1,475 citations

Isolated removal of hypothalamic or other brain nuclei of the rat

1973 • 1,421 citations

Gonadal Steroid Induction of Structural Sex Differences in the Central Nervous System

1984 • 1,170 citations

Sexual differentiation of the brain

1981 • 911 citations

Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

1980 • 836 citations

The Formation of Estrogens by Central Neuroendocrine Tissues

1975 • 794 citations

Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat

1980 • 584 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

A Sexually Dimorphic Nucleus in the Human Brain

1985 • 515 citations

Two sexually dimorphic cell groups in the human brain

1989 • 460 citations

Neural Gonadal Steroid Actions

1981 • 451 citations

The Hormonal Control of Sexual Development

1981 • 448 citations

Aromatization: Important for sexual differentiation of the neonatal rat brain

1977 • 447 citations

Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.

1992 • 431 citations

Testosterone: A Major Determinant of Extragenital Sexual Dimorphism

1981 • 391 citations

Discrete Lesions Reveal Functional Heterogeneity of Suprachiasmatic Structures in Regulation of Gonadotropin Secretion in the Female Rat

1982 • 347 citations

Cross-Talk between Peptide Growth Factor and Estrogen Receptor Signaling Pathways

1998 • 334 citations

Convergent Pathways for Steroid Hormone- and Neurotransmitter-Induced Rat Sexual Behavior

1994 • 332 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

On the Genesis of Sexual Differentiation of the Central Nervous System: Morphogenetic Consequences of Steroidal Exposure and Possible Role of α-Fetoprotein

1984 • 263 citations

Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

1993 • 261 citations

Neural Mechanisms of Female Reproductive Behavior

1985 • 256 citations

Regulation of Estrogen Receptor Messenger Ribonucleic Acid in Rat Hypothalamus by Sex Steroid Hormones

1991 • 216 citations

Estrogen Receptor Messenger RNA Expression in Rat Hypothalamus as a Function of Genetic Sex and Estrogen Dose*

1991 • 211 citations

Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males.

1992 • 206 citations

The distribution of monoaminergic cells and fibers in a periventricular preoptic nucleus involved in the control of gonadotropin release: Immunohistochemical evidence for a dopaminergic sexual dimorphism

1985 • 203 citations

Sexual dimorphism in synaptic organization in the amygdala and its dependence on neonatal hormone environment

1981 • 195 citations

Androgens Regulate Brain Aromatase Activity in Adult Male Rats through a Receptor Mechanism*

1984 • 186 citations

Sex differences in rat brain oestrogen and progestin receptors

1982 • 184 citations

Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro. II. Morphological correlates and hormonal specificity

1980 • 176 citations

Mechanisms of estrogen action during neural development: Mediation by interactions with the neurotrophins and their receptors?

1996 • 175 citations

The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study.

1989 • 173 citations

Hormonal control of the development and regulation of tyrosine hydroxylase expression within a sexually dimorphic population of dopaminergic cells in the hypothalamus

1989 • 167 citations

Hemispheric Asymmetries in the Behavioral and Hormonal Effects of Sexually Differentiating Mammalian Brain

1982 • 158 citations

Estrogen and insulin synergism in neurite growth enhancement in vitro: mediation of steroid effects by interactions with growth factors?

1988 • 148 citations

Sex Difference in Estradiol Regulation of Progestin Receptor mRNA in Rat Mediobasal Hypothalamus as Demonstrated by in situ Hybridization

1991 • 136 citations

Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding.

1992 • 132 citations

Mapping the Primate Visual System with [2- ¹⁴ C]Deoxyglucose

1982 • 128 citations

Characterization of Estrogen-Concentrating Hypothalamic Neurons by Their Axonal Projections

1982 • 128 citations

Neuroanatomical specificity in the co‐localization of aromatase and estrogen receptors

1991 • 125 citations

Structural Sexual Dimorphisms in the Anteroventral Periventricular Nucleus of the Rat Hypothalamus Are Sensitive to Gonadal Steroids Perinatally, but Develop Peripubertally

1996 • 124 citations

Transcription of the Y chromosomal gene,Sry, in adult mouse brain

1995 • 122 citations

The distribution of neurotransmitter-specific cells and fibers in the anteroventral periventricular nucleus: Implications for the control of gonadotropin secretion in the rat

1987 • 120 citations

Interactions of Estrogen with the Neurotrophins and Their Receptors during Neural Development

1994 • 120 citations

Genetic Evidence for Androgen-Dependent and Independent Control of Aromatase Activity in the Rat Brain*

1987 • 116 citations

Gonadal Activity and Sexual Differentiation of the Hypothalamus

1965 • 109 citations

Developmental profile of estrogen receptor mRNA in the preoptic area of male and female neonatal rats

1994 • 106 citations

Estradiol-17β: a metabolite of testosterone recovered in cell nuclei from limbic areas of adult male rat brains

1975 • 106 citations

Developmental Expression of Estrogen Receptor mRNA in the Rat Cerebral Cortex: A Nonisotopic in situ Hybridization Histochemistry Study

1992 • 105 citations

Partial Demasculinization and Feminization of Sex Behavior in Male Rats by in Utero and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Not Associated with Alterations in Estrogen Receptor Binding or Volumes of Sexually Differentiated Brain

1994 • 99 citations

Induction and Facilitation of Female Mating Behavior in Rats Treated Neonatally with Low Doses of Testosterone Propionate

1969 • 98 citations

Perinatal development of estrogen receptors in mouse brain assessed by radioautography, nuclear isolation and receptor assay

1983 • 97 citations

Cross talk between peptide growth factor and estrogen receptor signaling systems.

1995 • 96 citations

Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids

1990 • 95 citations

Cellular variations in estrogen receptor mRNA translation in the developing brain: evidence from combined [125I]estrogen autoradiography and non-isotopic in situ hybridization histochemistry

1992 • 95 citations

Organotypic culture of the developing cerebral cortex and hypothalamus: Relevance to sexual differentiation

1991 • 94 citations

The effects of an inhibitor of aromatization (1,4,6-androstatriene-3,17-dione) and an anti-estrogen (Cl-628) on in vivo formed testosterone metabolites recovered from neonatal rat brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brain

1977 • 94 citations

Regional Sex Differences in Cell Nuclear Estrogen-Binding Capacity in the Rat Hypothalamus and Preoptic Area*

1988 • 92 citations

Activation of sexual reflexes of male rats by dihydrotestosterone but not estrogen

1979 • 92 citations

Regulation of Estrogen Receptor Concentrations in the Rat Brain: Effects of Sustained Androgen and Estrogen Exposure

1996 • 91 citations

Comparison of Age- and Sex-Related Changes in Cell Nuclear Estrogen-Binding Capacity and Progestin Receptor Induction in the Rat Brain*

1990 • 88 citations

Autoradiographic localization of [3H]estradiol related to steroid responsiveness in cultures of the newborn mouse hypothalamus and preoptic area

1980 • 87 citations

Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats: implications for the molecular basis of a sexually differentiated behavior

1990 • 87 citations

A receptor mediating sexual differentiation?

1974 • 87 citations

Sex Differences in the Development of Estrogen Receptors in the Rat Brain

1994 • 86 citations

SEXUAL BEHAVIOUR OF NEONATALLY CASTRATED RATS INJECTED DURING INFANCY WITH OESTROGEN AND DIHYDROTESTOSTERONE

1977 • 81 citations

Androgenic Influences on Feminine Sexual Behavior in Male and Female Rats: Defeminization Blocked by Prenatal Antiandrogen Treatment*

1978 • 77 citations

Changes in noradrenergic transmission alter the concentration of cytoplasmic progestin receptors in hypothalamus

1981 • 76 citations

Estrogen binding in the neonatal neocortex

1979 • 73 citations

Androgens stimulate the morphological maturation of embryonic hypothalamic aromatase-immunoreactive neurons in the mouse

1997 • 72 citations

Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex

1994 • 71 citations

Estradiol derived from testosterone in prenatal life affects the development of catecholamine systems in the frontal cortex in the male rat

1994 • 71 citations

Androgens influence sexual differentiation of embryonic mouse hypothalamic aromatase neurons in vitro.

1994 • 69 citations

Organizational Effects of Testosterone via Aromatization on Feminine Reproductive Behavior and Neural Progestin Receptors in Rat Brain*

1984 • 69 citations

Perinatal Effects of Sex Steroids on Brain Development and Function

1973 • 68 citations

Sex steroids promote neurite growth in mesencephalic tyrosine hydroxylase immunoreactive neurons in vitro

1987 • 68 citations

Dilute Estradiol Implants and Progestin Receptor Induction in the Ventromedial Nucleus of the Hypothalamus: Correlation with Receptive Behavior in Female Rats*

1989 • 67 citations

Synapse formation in response to estrogen in the medial amygdala developing in the eye.

1982 • 66 citations

Perinatal development of hypothalamic and cortical estrogen receptors in mouse brain: Methodological aspects

1983 • 64 citations

Nerve growth factor (NGF) regulation of estrogen receptors in explant cultures of the developing forebrain

1996 • 64 citations

Luteinizing Hormone-Releasing Hormone Neuronal System during the Estrous Cycle of the Female Rat:

1986 • 63 citations

Rat cerebral cortical estrogen receptors: Male-female, right-left

1986 • 63 citations

Genotype-dependent sex differentiation of dopaminergic neurons in primary cultures of embryonic mouse brain

1996 • 61 citations

Sex differences in densities of dopaminergic fibers and GABAergic neurons in the prenatal rat striatum

1992 • 61 citations

Making Males from Females: The Effects of Aromatase Inhibitors on a Parthenogenetic Species of Whiptail Lizard

1995 • 61 citations

Sex-Specific Aromatization of Testosterone in Mouse Hypothalamic Neurons

1993 • 59 citations

Androgen receptors in the perinatal rat brain

1980 • 57 citations

Circulating gonadal steroid hormones regulate estrogen receptor mRNA in the male rat forebrain

1993 • 56 citations

Sex steroids do not alter sex differences in tyrosine hydroxylase activity of dopaminergic neurons in vitro

1992 • 56 citations

Immunocytochemical Identification of Oestrogen Receptors in Preoptic Neurones Containing Calcitonin Gene-Related Peptide in the Male and Female Rat

1992 • 53 citations

Distribution of occupied and unoccupied estrogen receptors in the rat brain: effects of physiological gonadal steroid exposure.

1995 • 51 citations

Sexual dimorphism in the developmental regulation of brain aromatase

1995 • 50 citations

Sexual differentiation of estrogen receptor concentrations in the rat brain: effects of neonatal testosterone exposure

1995 • 49 citations

A site for estradiol priming of progesterone-facilitated sexual receptivity in the ventrolateral hypothalamus of female guinea pigs

1991 • 46 citations

Morphometric studies demonstrate that aromatase-immunoreactive cells are the main target of androgens and estrogens in the quail medial preoptic nucleus

1994 • 46 citations

INFLUENCE OF AGE AND PRESENCE OF THE OVARIES ON REPRODUCTIVE FUNCTION IN RATS INJECTED WITH ANDROGENS¹

1941 • 39 citations

In vitro labeling of gonadal steroid hormone receptors in brain tissue sections

1995 • 37 citations

Characterization of 11β-Methoxy-16α-[¹²⁵I]Iodoestradiol Binding: Neuronal Localization of Estrogen-Binding Sites in the Developing Rat Brain*

1989 • 37 citations

Androgen-induced Sexual Differentiation of the Brain is Blocked by Inhibitors of DNA and RNA Synthesis

1974 • 34 citations

Androgen Treatment Decreases Estrogen Receptor Binding in the Ventromedial Nucleus of the Rat Brain: A Quantitative in Vitro Autoradiographic Analysis

1994 • 34 citations

Steroid autoradiography of the sexually dimorphic nucleus of the preoptic area

1987 • 33 citations

Effect of 5α-Dihydrotestosterone on Sexual Receptivity and Neural Progestin Receptors in Ovariectomized Rats Given Pulsed Estradiol1

1985 • 33 citations

Aromatase-immunoreactive neurons in the adult female chicken brain detected using a specific antibody

1994 • 32 citations

Neurite-like outgrowth from CNS explants may not always be of neuronal origin

1990 • 29 citations

Brain formation of oestrogen in the mouse: Sex dimorphism in aromatase development

1994 • 28 citations

Sex differences in estrogen receptor binding in the rat hypothalamus: effects of subsaturating pulses of estradiol

1992 • 28 citations

Sex differences in estrogen receptor and progestin receptor induction in the guinea pig hypothalamus and preoptic area

1996 • 26 citations

Attenuating the defeminization of the neonatal rat brain: Mechanisms of action of cyproterone acetate, 1,4,6-androstatriene-3,17,-dione and a synthetic progestin, R5020

1979 • 25 citations

A Reevaluation of the Concept of Separable Periods of Organizational and Activational Actions of Estrogens in Development of Brain and Behavior

1986 • 25 citations

Steroids induce hypothalamic progestin receptors and facilitate female sexual behavior in neonatal rats

1988 • 24 citations

A subset of progesterone target neurons have axonal projections to the midbrain

1990 • 23 citations

Interactions Between Estrogen and EGF in Uterine Growth and Function

1987 • 23 citations

Gonadal hormones and sexual reflexes in the female rat

1969 • 22 citations

Phosphorylation and estradiol binding of estrogen receptor in hormone‐dependent and hormone‐independent GR mouse mammary tumors

1992 • 21 citations

Sex Differentiation of Rat Hippocampal GABAergic Neurons

1996 • 20 citations

Estrogen and Androgen Distribution in the Brain of Neonatal Rats1

2015 • 20 citations

Pubertal Development of Estrogen Receptors in the Rat Brain

1994 • 17 citations

Gonadal steroids and brain development

1981 • 16 citations

Asymmetry in responsiveness of the hypothalamus of the female rat to estradiol

1987 • 16 citations

In vitro autoradiographic visualization of occupied estrogen receptors in the rat brain with an iodinated estrogen ligand.

1993 • 12 citations

Autoradiographic and Microchemical Methods for Quantitation of Steroid Receptors

1990 • 11 citations

Phosphorylation of Estradiol Receptor on Tyrosine and Interaction of Estradiol and Glucocorticoid Receptors with Antiphosphotyrosine Antibodies

1988 • 5 citations

In Vitro Autoradiography for Steroid Receptors

1994 • 2 citations

Deleted Work

1955 • 0 citations