The Anti-CD3-Induced Syndrome: A Consequence of Massive In Vivo Cell Activation

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

1979 • 1,480 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants

1985 • 697 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts

1981 • 511 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.

1985 • 466 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Genetic Control of Leucocyte Responses to Endotoxin

1968 • 384 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

RELEASE OF TUMOR NECROSIS FACTOR, INTERLEUKIN-2, AND GAMMA-INTERFERON IN SERUM AFTER INJECTION OF OKT3 MONOCLONAL ANTIBODY IN KIDNEY TRANSPLANT RECIPIENTS

1989 • 361 citations

Identification of the components of the murine T cell antigen receptor complex

1985 • 333 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

IN VIVO CELL ACTIVATION FOLLOWING OKT3 ADMINISTRATION

1990 • 309 citations

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?

1981 • 306 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1985 • 286 citations

Cytokine‐related syndrome following injection of anti‐CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation

1990 • 267 citations

Acute in vivo effects of human recombinant tumor necrosis factor.

1987 • 256 citations

Immunologic Properties of Bacterial Lipopolysaccharide (LPS): Correlation between the Mitogenic, Adjuvant, and Immunogenic Activities

1975 • 242 citations

Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.

1986 • 241 citations

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

1989 • 198 citations

The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins.

1983 • 194 citations

Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses.

1988 • 172 citations

Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression.

1986 • 171 citations

Tolerance to rat monoclonal antibodies. Implications for serotherapy.

1986 • 161 citations

ANTI-CD3 F(abʼ)2 FRAGMENTS ARE IMMUNOSUPPRESSIVE IN VIVO WITHOUT EVOKING EITHER THE STRONG HUMORAL RESPONSE OR MORBIDITY ASSOCIATED WITH WHOLE mAb

1990 • 124 citations

The δ- and ε-chains of the human T3/T-cell receptor complex are distinct polypeptides

1984 • 113 citations

Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes.

1984 • 107 citations

CORTICOSTEROID INHIBITION OF THE OKT3-INDUCED CYTOKINE-RELATED SYNDROME

1991 • 97 citations

Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.

1987 • 90 citations

Induction of T cell proliferation with anti‐CD3 switch‐variant monoclonal antibodies: effects of heavy chain isotype in monocyte‐dependent systems

1987 • 90 citations

Pneumopathies of the graft-versus-host reaction. Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis.

1989 • 89 citations

Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.

1988 • 88 citations

Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia.

1990 • 87 citations

Transplantation: Approaches to graft rejection

1988 • 86 citations

Genetic control of endotoxic responses in mice.

1978 • 85 citations

Hypothermia and hypoglycemia induced by anti‐CD3 monoclonal antibody in mice: Role of tumor necrosis factor

1990 • 83 citations

Antigenic modulation - a major mechanism of antibody action

1984 • 76 citations

The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits.

1985 • 76 citations

EFFECTS OF IN VIVO ADMINISTRATION OF MONOCLONAL ANTIBODIES SPECIFIC FOR HUMAN T CELL SUBPOPULATIONS ON THE IMMUNE SYSTEM IN A RHESUS MONKEY MODEL

1983 • 76 citations

REDUCTION OF MORBIDITY AND CYTOKINE RELEASE IN ANTI-CD3 MoAb-TREATED MICE BY CORTICOSTEROIDS

1990 • 62 citations

Nosocomial Aseptic Meningitis Associated With Administration of OKT3

1988 • 62 citations

Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cells

1976 • 53 citations

Clinical development of Orthoclone OKT3.

1987 • 53 citations

ACTIVATION OF HUMAN T CELLS IN VIVO FOLLOWING TREATMENT OF TRANSPLANT RECIPIENTS WITH OKT3

1990 • 49 citations

Anti-TNF abrogates the cytokine-related anti-CD3 induced syndrome.

1991 • 26 citations

Clinical use of OKT3: The role of cytokine release and xenosensitization

1988 • 25 citations

OKT3 monoclonal antibody reversal of acute renal allograft rejection unresponsive to conventional immunosuppressive treatments.

1986 • 13 citations