Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le ^x

1990 • 1,315 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

The phagokinetic tracks of 3T3 cells

1977 • 434 citations

Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.

1991 • 359 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Superoxide Radical and Superoxide Dismutases: Threat and Defense

1980 • 178 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

Surface‐reactive stimuli selectively increase protein phosphorylation in human neutrophils

1981 • 134 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.

1991 • 123 citations

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

1988 • 119 citations

Protein factors which regulate cell motility

1989 • 100 citations

The selective binding and transmigration of monocytes through the junctional complexes of human endothelium.

1988 • 78 citations

Characteristic expression of glycosphingolipid profiles in the bipotential cell differentiation of human promyelocytic leukemia cell line HL-60

1984 • 77 citations

Enzymatic synthesis of N,N-dimethyl-sphingosine: Demonstration of the sphingosine: N-methyltransferase in mouse brain

1989 • 73 citations

Sphingolipid base metabolism. Partial purification and properties of sphinganine kinase of brain.

1976 • 68 citations

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1991 • 66 citations

Sphingosine Kinase in Blood Platelets

1973 • 66 citations

New directions in cancer therapy based on aberrant expression of glycosphingolipids: anti-adhesion and ortho-signaling therapy.

1991 • 63 citations

Stereospecificities in the Metabolic Reactions of the four Isomeric Sphinganines (Dihydrosphingosines) in Rat Liver

1973 • 61 citations

Properties and Specificities of Sphingosine Kinase from Blood Platelets

1973 • 58 citations

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.

1989 • 55 citations

Short chain ceramides as substrates for glucocerebroside synthetase. Differences between liver and brain enzymes

1979 • 50 citations

A facile and regiospecific tritiation of sphingosine: Synthesis of (2S,3R,4E)‐2‐amino‐4‐octadecene‐1,3‐diol‐1‐³H

1991 • 50 citations

Protein kinase C inhibition by sphingoid long-chain bases: Effects on secretion in human neutrophils

1987 • 42 citations

The Metabolism of Sphingosine Bases in Tetrahymena pyriformis. Sphingosine Kinase and Sphingosine-1-phosphate Lyase

1974 • 41 citations

CAPILLARY GROWTH FROM REVERSED RAT AORTIC SEGMENTS CULTURED IN COLLAGEN GEL

1988 • 41 citations

Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine

1991 • 36 citations

Phosphorylation of both 47 and 49kDa proteins accompanies superoxide release by neutrophils

1989 • 34 citations

[51] Measurement of oxidizing radicals by polymorphonuclear leukocytes

1984 • 34 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase

1989 • 19 citations

Possible Roles of Sphingosine and N, N-Dimethylsphingosine as Modulators in Membrane Signal Transduction Systems

1990 • 5 citations