Mechanism of lymphocyte-mediated cytolysis: functional cytolytic T cells lacking perforin and granzymes.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Homology of perforin to the ninth component of complement (C9)

1988 • 268 citations

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

1983 • 225 citations

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

1987 • 196 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

REJECTION OF ASCITES TUMOR ALLOGRAFTS

1972 • 145 citations

Interaction of Cytotoxic T Lymphocytes and Target Cells

2015 • 139 citations

Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.

1990 • 106 citations

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

1991 • 104 citations

Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

1990 • 93 citations

Multiple mechanisms of lymphocyte-mediated killing

1988 • 90 citations

Role of Perforin in Lymphocyte-Mediated Cytolysis

1992 • 89 citations

Lymphocyte-triggered internal target disintegration

1991 • 75 citations

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.

1990 • 73 citations

High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.

1987 • 72 citations

Cytotoxic T lymphocyte hybridomas that mediate specific tumor-cell lysis in vitro.

1981 • 72 citations

T-lymphocyte-mediated cytolysis as an excitatory process of the target

1985 • 71 citations

Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.

1987 • 70 citations

Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity

1974 • 70 citations

Cytolytic and biochemical properties of cytoplasmic granules of murine lymphokine-activated killer cells.

1986 • 70 citations

A calcium- and perforin-independent pathway of killing mediated by murine cytolytic lymphocytes.

1987 • 64 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. IX. Relationships between antigen recognition and lytic expression in killer T cells.

1977 • 62 citations

Perforin-induced pore formation

1991 • 61 citations

CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always.

1987 • 59 citations

Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes.

1989 • 43 citations

Resistance of mouse cytolytic cells to pore‐forming protein‐mediated cytolysis

1988 • 41 citations

Metabolic inhibitors distinguish cytolytic activity of CD4 and CD8 clones

1990 • 37 citations

Are lytic granules and perforin 1 involved in lysis induced by in vivo-primed peritoneal exudate cytolytic T lymphocytes?

1987 • 37 citations

Antigen-specific directional target cell lysis by perforin-negative T lymphocyte clones

1991 • 36 citations

Monoclonal cytotoxic T lymphocyte hybridomas capable of specific killing activity, antigenic responsiveness, and inducible interleukin secretion.

1983 • 33 citations

Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo

1990 • 27 citations

Resistance of cytolytic lymphocytes to perforin-mediated killing. Murine cytotoxic T lymphocytes and human natural killer cells do not contain functional soluble homologous restriction factor or other specific soluble protective factors.

1989 • 19 citations

Target cell lysis by cytotoxic T lymphocytes that lack detectable hemolytic perforin activity.

1988 • 18 citations

The lysis of cytotoxic T lymphocytes and their blasts by cytotoxic T lymphocytes.

1990 • 18 citations

Identification of a macrophage-activating factor in granules of the RNK large granular lymphocyte leukemia.

1989 • 10 citations

Memory CTL-hybridoma: a model system to analyze the anamnestic response of cytolytic T lymphocytes.

1984 • 5 citations