Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

Characteristics of human large granular lymphocytes and relationship to natural killer and K cells

1981 • 1,008 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Structure and function of human perforin

1988 • 346 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Homology of perforin to the ninth component of complement (C9)

1988 • 268 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

T‐Lymphocyte Activation: The Role of Protein Kinase C and the Bifurcating Inositol Phospholipid Signal Transduction Pathway

1987 • 203 citations

The Effector Cells in Human Peripheral Blood Mediating Mitogen-Induced Cellular Cytotoxicity and Antibody-Dependent Cellular Cytotoxicity

1976 • 173 citations

Isolation of human and rat natural killer cells

1982 • 169 citations

Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor.

1989 • 154 citations

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

1988 • 152 citations

Activation of natural killer cells via the p75 interleukin 2 receptor.

1989 • 133 citations

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.

1987 • 128 citations

One-signal requirement for interferon-gamma production by human large granular lymphocytes.

1987 • 116 citations

T Cell CD3-ζη Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis

1988 • 113 citations

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

1987 • 86 citations

Perforin‐Dependent and ‐Independent Pathways of Cytotoxicity Mediated by Lymphocytes

1988 • 86 citations

Human Natural Lymphocyte Effector Cells: Definition, Analysis of Activity, and Clinical Effectiveness

1988 • 78 citations

Protein kinase C required for cytotoxic T lymphocyte triggering.

1987 • 74 citations

Activation of peripheral blood T cells via the p75 interleukin 2 receptor.

1989 • 70 citations

IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor.

1989 • 65 citations

The effect of interferon on lymphocyte-mediated effector cell functions: Selective enhancement of natural killer cells

1979 • 63 citations

Activation of human peripheral blood mononuclear cells by anti-T3: killing of tumor target cells coated with anti-target-anti-T3 conjugates.

1986 • 63 citations

Perforin gene expression in granular lymphocyte proliferative disorders

1990 • 52 citations

Molecular cloning and chromosomal assignment of a human perforin (PFP) gene

1989 • 51 citations

Augmentation of Human K‐Cell Activity with Interferon

1980 • 47 citations

Antigen-receptor interaction requirement for conjugate formation and lethal-hit triggering by cytotoxic T lymphocytes can be bypassed by protein kinase C activators and Ca2+ ionophores.

1987 • 39 citations

Distinct Reactivities of Four Monoclonal Antibodies with Human Interleukin 2 Receptor

1985 • 29 citations

A Comparison of the Cytolytic Properties of Murine Primary CD8+ Cytotoxic T Lymphocytes and Cloned Cytotoxic T Cell Lines

1988 • 26 citations

Growth factor production and requirements during the proliferative response of human T lymphocytes to anti-CD3 monoclonal antibody.

1989 • 26 citations

Induction of synthesis of the cytolytic C9 (ninth component of complement)-related protein in human peripheral mononuclear cells by monoclonal antibody OKT3 or interleukin 2: correlation with cytotoxicity and lymphocyte phenotype.

1987 • 18 citations