Melanoma x macrophage hybrids with enhanced metastatic potential.

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Hypervariability of simple sequences as a general source for polymorphic DNA markers

1989 • 2,356 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Antibodies to major histocompatibility antigens produced by hybrid cell lines

1977 • 1,727 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites

1990 • 475 citations

23 Genetic instability induced by the tumor microenvironment

1997 • 429 citations

Rat gene mapping using PCR-analyzed microsatellites.

1992 • 343 citations

The use of drug-resistant markers to study the hybridization of mouse fibroblasts

1966 • 326 citations

Suppression of malignancy in human cells

1976 • 313 citations

MACROPHAGES IN SYNGENEIC ANIMAL TUMOURS

1972 • 295 citations

CD44 splice variants: metastases meet lymphocytes

1993 • 268 citations

The analysis of malignancy by cell fusion: I. hybrids between tumour cells and l cell derivatives

1971 • 251 citations

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.

1993 • 233 citations

Establishment of Four Functional, Clonal Strains of Animal Cells in Culture

1966 • 204 citations

The analysis of malignancy by cell fusion. VII. cytogenetic analysis of hybrids between malignant and diploid cells and of tumours derived from them

1977 • 201 citations

The analysis of malignancy by cell fusion: the position in 1988.

1988 • 173 citations

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

1992 • 168 citations

Microcosmos: Four Billion Years of Evolution from Our Microbial Ancestors

1998 • 162 citations

Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization.

1966 • 148 citations

In vivo hybridisation of human tumour and normal hamster cells

1974 • 147 citations

Tumor suppressor genes

1993 • 147 citations

Spontaneous fusion in vivo between normal host and tumor cells: possible contribution to tumor progression and metastasis studied with a lectin-resistant mutant tumor.

1983 • 145 citations

Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection.

1987 • 120 citations

How Cancer Spreads

1996 • 120 citations

Small Cell Carcinoma of the Lung: Macrophage-Specific Antigens Suggest Hemopoietic Stem Cell Origin

1984 • 116 citations

Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the test is

1987 • 115 citations

The analysis of malignancy by cell fusion: V. further evidence of the ability of normal diploid cells to suppress malignancy

1974 • 103 citations

The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells.

1995 • 102 citations

Human Serum Albumin Phenotype Activation in Mouse Hepatoma-Human Leukocyte Cell Hybrids

1974 • 96 citations

Suggestive evidence that the highly metastatic variant ESB of the T‐cell lymphoma eb is derived from spontaneous fusion with a host macrophage

1984 • 91 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: High Frequency of Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Lymphoblast Hybrids

1974 • 88 citations

Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low‐metastatic H‐2 heterozygous tumor cell line into an H‐2 incompatible parental strain

1978 • 87 citations

Location of genes involved in invasion and metastasis on human chromosome 7.

1987 • 85 citations

Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants

1984 • 85 citations

Genetic Analysis of Mammalian Cell Differentiation

1990 • 83 citations

Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells

1984 • 81 citations

Formation of Multinucleated Giant Cells In Vitro Is Dependent on the Stage of Monocyte to Macrophage Maturation

1997 • 81 citations

The macrophage content of some human tumours

1975 • 81 citations

Characteristics of “Hybrid”-Type Clonal Cell Lines Obtained From Mixed Cultures <italic>In Vitro</italic><xref ref-type="fn" rid="fn1">2</xref>

1962 • 74 citations

Hybridization of Normal and Neoplastic Cells in vitro

1965 • 68 citations

Generation of invasive and metastatic variants of a non‐metastatic T‐cell lymphoma by in vivo fusion with normal host cells

1984 • 68 citations

PROPERTIES OF HYBRIDS BETWEEN POLYOMA-TRANSFORMED AND NORMAL MOUSE CELLS

1967 • 67 citations

Metastatic Properties Conferred on Nonmetastatic Tumors by Hybridization of Spleen B-Lymphocytes With Plasmacytoma Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 66 citations

Current Concepts of the Biology of Human Cutaneous Malignant Melanoma

1977 • 66 citations

Fusion of Tumour Cells with Host Cells

1972 • 65 citations

Acquisition of high metastatic capacity after in vitro fusion of a nonmetastatic tumor line with a bone marrow-derived macrophage.

1984 • 64 citations

Melanoma cells which require cyclic AMP for growth

1975 • 62 citations

Invasiveness of T-cell hybridomas in vitro and their metastatic potential in vivo.

1985 • 62 citations

Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations.

1989 • 61 citations

Spontaneous fusion between metastatic mammary tumor subpopulations

1988 • 59 citations

IS CANCER A MACROPHAGE-MEDIATED AUTOAGGRESSIVE DISEASE?

1987 • 59 citations

The Effect of an Extra-Chromosomal Influence upon Transplanted Spontaneous Tumors in Mice

1941 • 59 citations

In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydrogenase and lactate dehydrogenase profiles.

1971 • 57 citations

Gene expression, cellular diversification and tumor progression to the metastatic phenotype

1991 • 53 citations

The use of cell fusion to analyse factors involved in tumour cell metastasis

1983 • 52 citations

Supermelanotic hybrids derived from mouse melanomas and normal mouse cells

1980 • 45 citations

Cell hybridization: An explanation for the phenotypic diversity of certain tumours

1975 • 44 citations

Spontaneous Fusion In Vivo Between Normal Host and Tumor Cells: Possible Contribution to Tumor Progression and Metastasis Studied with a Lectin-Resistant Mutant Tumor

1983 • 44 citations

Premature chromosome condensation in carcinoma of the bladder: presumptive evidence for fusion of normal and malignant cells

1979 • 42 citations

Invasiveness in hepatocyte and fibroblast monolayers and metastatic potential of T-cell hybridomas in mice.

1988 • 40 citations

Premature chromosome condensation: Evidence for in vivo cell fusion in human malignant tumours

1985 • 40 citations

Tumor-Host Cell Hybrids in Radiochimeras

1974 • 38 citations

Efficient Spontaneous Fusion Between Some Co‐cultured Cells, Especially Murine Melanoma Cells

1994 • 37 citations

Tumor x Host Cell Hybrids in the Mouse: Chromosomes From the Normal Cell Parent Maintained in Malignant Hybrid Tumors 2

1977 • 37 citations

Methods for serum-free culture of neuronal and lymphoid cells

1984 • 33 citations

[Hybridization of transformed cells with lymphocytes as 1 of the probable causes of the progression leading to the development of metastatic malignant cells].

1971 • 33 citations

Genotypic and Phenotypic Evolution of a Murine Tumor During Its Progression In Vivo Toward Metastasis<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 33 citations

Towards an understanding of the molecular basis of the metastatic phenotype.

1989 • 31 citations

In vivo Hybridisation of Cultured Melanoma Cells and Isogenic Normal Mouse Cells

1975 • 30 citations

Somatic cell hybridization in vivo and in vitro in relation to the metastatic phenotype

1985 • 30 citations

Cell fusion in tumor development and progression: Occurrence of cell fusion in primary methylcholanthrene‐induced tumorigenesis

1989 • 29 citations

Growth advantage (“clonal dominance”) of metastatically competent tumor cell variants expressed under selective two- or three-dimensional tissue culture conditions

1993 • 24 citations

Tumor suppressor genes

1995 • 24 citations

Enhanced lung colonization and tumorigenicity of fused cells isolated from primary MCA tumors

1990 • 19 citations

Hybrid cells in solid tumors

1971 • 18 citations

Inheritance of Immunogenicity and Metastatic Potential in Murine Cell Hybrids from the T-Lymphoma ESb08 and Normal Spleen Lymphocytes<xref ref-type="fn" rid="FN2">2</xref>

1984 • 18 citations

Tumor cell hybridization and neoplastic progression.

1983 • 17 citations

The analysis of malignancy by cell fusion

1980 • 17 citations

Syngeneic in vivo passage of the murine BW 5147 lymphoma results in the expression of a stable metastatic phenotype

1988 • 15 citations

Tumorigenicity and intracisternal A-particle expression of hybrids between murine myeloma and lymphocytes.

1979 • 13 citations

Extinction of expression of the PU.1/Sfpi-1 putative oncogene encoding a B-cell- and macrophage-specific transcription factor in somatic cell hybrids.

1993 • 11 citations

Suppression of properties associated with malignancy in murine melanoma-melanocyte hybrid cells

1992 • 10 citations

Pigment-cell-specific genes from fibroblasts are transactivated after chromosomal transfer into melanoma cells.

1994 • 9 citations

Sporadic somatic fusion between MDAY‐D2 murine tumor cells and DBA/2 host cells: Role in metastasis

1986 • 9 citations

Coordinate extinction of melanocyte-specific gene expression in hybrid cells

1996 • 8 citations

The Fusion of Tumor Cells with Host Cells; Reflections on an Ovarian Tumor

1995 • 7 citations

In vivo tumour × host cell fusion in spontaneous syrian hamster metastasis

1989 • 4 citations

Pigment-Cell-Specific Genes from Fibroblasts Are Transactivated after Chromosomal Transfer into Melanoma Cells

1994 • 2 citations