Current Concepts of the Biology of Human Cutaneous Malignant Melanoma

Thickness, Cross-Sectional Areas and Depth of Invasion in the Prognosis of Cutaneous Melanoma

1970 • 2,415 citations

The histogenesis and biologic behavior of primary human malignant melanomas of the skin.

1969 • 2,098 citations

Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx

1970 • 1,261 citations

Malignant melanoma. A clinicopathological analysis of the criteria for diagnosis and prognosis

1953 • 988 citations

Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas

1976 • 864 citations

Demonstration of cell‐mediated immunity to human neoplasms of various histological types

1971 • 673 citations

Impaired immunologic reactivity and recurrence following cancer surgery

1970 • 668 citations

Marker Band in One Chromosome 14 from Burkitt Lymphomas

1972 • 628 citations

Human Lymphocyte Migration as a Parameter of Hypersensitivity

1967 • 563 citations

In vitro Cell Migration as a Model for Delayed Hypersensitivity.

1962 • 555 citations

Tumor Thickness, Level of Invasion and Node Dissection in Stage I Cutaneous Melanoma

1975 • 531 citations

The experimental study of tumor progression: a review.

1954 • 522 citations

The Immune-Adherence Phenomenon

1953 • 487 citations

Delayed Hypersensitivity in vitro. I. The Specificity of Inhibition of Cell Migration by Antigens.

1964 • 466 citations

Immunological factors which influence response to immunotherapy in malignant melanoma.

1970 • 462 citations

The classification of malignant melanoma and its histologic reporting

1973 • 442 citations

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

1971 • 423 citations

Antibodies to Epstein-Barr Virus in Burkitt's Lymphoma and Control Groups<xref ref-type="fn" rid="FN2">2</xref>

1969 • 421 citations

Tumour-specific Antibodies in Human Malignant Melanoma and their Relationship to the Extent of the Disease

1969 • 396 citations

Reactivity of lymphocytes from normal persons on cultured tumor cells.

1973 • 383 citations

Giant Pigmented Nevi, Melanoma, and Leptomeningeal Melanocytosis

1965 • 338 citations

Lentigo maligna and lentigo-maligna melanoma.

1969 • 336 citations

The developmental biology of primary human malignant melanomas.

1975 • 336 citations

SPONTANEOUS REGRESSION OF CANCER

1964 • 322 citations

Delayed Hypersensitivity in Vitro

1964 • 315 citations

Spontaneous regression of primary malignant melanomas with regional metastases

1965 • 304 citations

MACROPHAGES IN SYNGENEIC ANIMAL TUMOURS

1972 • 295 citations

THE RISK OF MALIGNANCY IN LARGE CONGENITAL NEVI

1974 • 293 citations

Prevalence, Incidence and Persistence of EB Virus Antibody in Young Adults

1970 • 292 citations

Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen

1972 • 289 citations

The classification of melanoma and its relationship with prognosis

1970 • 286 citations

Congenital melanocytic nevi of the small and garment typeClinical histologic, and ultrastructural studies

1973 • 274 citations

Etiology of Burkitt's Lymphoma—an Alternative Hypothesis to a Vectored Virus

1969 • 267 citations

Relationship between Epstein‐Barr virus (EBV) DNA and the EBV‐determined nuclear antigen (EBNA) in Burkitt lymphoma biopsies and other lymphoproliferative malignancies

1974 • 267 citations

The Epstein-Barr Virus and Neoplasia

1975 • 235 citations

ACTIVE IMMUNOTHERAPY WITH B.C.G. FOR RECURRENT MALIGNANT MELANOMA

1973 • 235 citations

DNA of Epstein-Barr Virus Detected in Tissue of Burkitt's Lymphoma and Nasopharyngeal Carcinoma

1973 • 231 citations

END RESULTS IN THE TREATMENT OF MALIGNANT MELANOMA

1952 • 213 citations

Biology of Normal and Abnormal Melanocytes

1972 • 207 citations

A reorientation on the histogenesis and clinical significance of cutaneous nevi and melanomas

1949 • 203 citations

SOME GEOGRAPHICAL ASPECTS OF THE MORTALITY FROM MELANOMA IN EUROPEANS

1956 • 197 citations

Chemoimmunotherapy of Disseminated Malignant Melanoma with Dimethyl Triazeno Imidazole Carboxamide and Bacillus Calmette-Guérin

1974 • 197 citations

Malignant melanoma of the extremities: A clinicopathologic study using levels of invasion (microstage)

1975 • 189 citations

The regional anatomy of the human integument with special reference to the distribution of hair follicles, sweat glands and melanocytes

1967 • 184 citations

Metastatic Malignant Melanoma in Prepubertal Children

1975 • 184 citations

Adjuvant Immunotherapy with BCG in Treatment of Regional-Lymph-Node Metastases from Malignant Melanoma

1976 • 181 citations

Observations on Childhood Infections with the Epstein-Barr Virus

1970 • 180 citations

INCIDENCE OF MALIGNANCY IN GIANT PIGMENTED NEVI

1965 • 174 citations

QUALIFICATION AS CONSULTANT

1963 • 172 citations

Serum factors in tumor‐free patients cancelling the blocking of cell‐mediated tumor immunity

1971 • 164 citations

Recent data on the epidemiology of malignant melanoma.

1975 • 160 citations

Melanocytic and nevocytic malignant melanomas.Cellular and subcellular differentiation

1967 • 159 citations

SKIN TRANSPLANTATION IMMUNITY IN RELATION TO HYPERSENSITIVITY

1958 • 158 citations

Spontaneous regression of human melanoma.Clinical and experimental studies

1960 • 156 citations

Nasopharyngeal Carcinoma (NPC)

1972 • 156 citations

Proceedings: Escape from immune destruction by the host through shedding of surface antigens: is this a characteristic shared by malignant and embryonic cells?

1974 • 156 citations

Development and elimination of pigmented moles, and the anatomical distribution of primary malignant melanoma

1973 • 150 citations

Incidence of malignant melanoma of the skin in Norway, 1955–1970.Variations in time and space and solar radiation

1973 • 149 citations

Tumor thickness and lymphocytic infiltration in malignant melanoma of the head and neck

1974 • 149 citations

Sequential studies on cell‐mediated tumor immunity and blocking serum activity in ten patients with malignant melanoma

1973 • 148 citations

Relationship of Melanoma and other Skin Cancer Mortality to Latitude and Ultraviolet Radiation in the United States and Canada

1974 • 146 citations

Abnormalities of quantitative dinitrochlorobenzene sensitization in cancer patients: Correlation with tumor stage and histology

1973 • 143 citations

SUNLIGHT AS A CAUSE OF MELANOMA: A CLINICAL SURVEY

1957 • 143 citations

Cell-mediated cytotoxicity for bladder carcinoma: evaluation of a workshop.

1975 • 134 citations

GENETIC ASPECTS OF MALIGNANT MELANOMA

1952 • 134 citations

In Vitro Lymphocyte Stimulation by a Soluble Antigen from Malignant Melanoma

1970 • 131 citations

Immunization with Irradiated Tumour Cells and Specific Lymphocyte Cytotoxicity in Malignant Melanoma

1971 • 130 citations

Cellular and humoral immunity against human malignant melanoma

1971 • 120 citations

Part III: General Considerations of Skin Pigmentation: The Melanocyte: Cytology and Cytochemistry11From the Division of Dermatology, University of Oregon Medical School, Portland, Oregon and the Department of Anatomy, Emory University Medical School, Atlanta, Georgia.

1959 • 120 citations

Problems Associated With Study of Cell-Mediated Immunity to Human Tumors by Microcytotoxicity Assays

1975 • 119 citations

Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis

1971 • 118 citations

Cytogenetic studies on human lymphoblastoid cell lines from burkitt's lymphomas and other sources

1974 • 118 citations

Malignant Melanoma

1975 • 118 citations

Correlation of in vivo and in vitro assays of immunocompetence in cancer patients.

1974 • 115 citations

Antibodies to Early Epstein-Barr Virus-Induced Antigens in Burkitt&s Lymphoma<xref ref-type="fn" rid="FN2">2</xref>

1971 • 114 citations

Cytotoxity of non‐T versus T‐lymphocytes from melanoma patients and healthy donors on short‐ and long‐term cultured melanoma cells

1974 • 114 citations

SIGNIFICANCE OF HYPERMETHIONÆMIA IN ACUTE TYROSINOSIS

1968 • 111 citations

Epstein-Barr virus binding sites on lymphocyte subpopulations and the origin of lymphoblasts in cultured lymphoid cell lines and in the blood of patients with infectious mononucleosis

1975 • 107 citations

Ceinical characteristics of the genetic variety of cutaneous melanoma in man

1971 • 105 citations

Studies on Specificity of Cell-Mediated Immunity to Human Tumors<xref ref-type="fn" rid="fn2"><sup>2</sup></xref>

1974 • 103 citations

CUTANEOUS HYPERSENSITIVITY REACTIONS TO AUTOLOGOUS EXTRACTS OF MALIGNANT MELANOMA CELLS

1970 • 102 citations

Cytotoxic lymphocytes in melanoma patients

1972 • 102 citations

Primary malignant melanoma of the urinary bladder

1976 • 99 citations

Possible Explanation for Loss of Detectable Antibody in Patients with Disseminated Malignant Melanoma

1971 • 98 citations

Non-specific and specific immunotherapy in patients with melanoma.

1972 • 96 citations

Cell‐mediated and serum blocking reactivity to tumor antigens in patients with malignant melanoma

1973 • 95 citations

SUNLIGHT AND THE AETIOLOGY OF MALIGNANT MELANOMA: A SYNTHESIS

1970 • 93 citations

Heredity and malignant melanoma: implications for early cancer detection.

1968 • 87 citations

POSSIBLE IMMUNOLOGICAL FACTORS IN HUMAN MALIGNANT MELANOMA IN UGANDA

1967 • 87 citations

In vitro study of cellular immunity against autochthonous human cancer

1972 • 85 citations

Suspension Culture of a Pigment-Producing Cell Line Derived From a Human Malignant Melanoma<xref ref-type="fn" rid="FN2">2</xref>

1968 • 81 citations

Hereditary Aspects of Malignant Melanoma

1967 • 80 citations

The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors 1.The role of tissue antigen, nonspecific reactions of nuclear material, and bacterial antigen as a cause for this phenomenon

1969 • 80 citations

Spontaneous regression of malignant melanoma

1974 • 79 citations

Secular Trends in Mortality From Malignant Melanoma<xref ref-type="fn" rid="FN2">2</xref>

1970 • 77 citations

Clinical and immunological significance of human melanoma cytotoxic antibody.

1975 • 76 citations

SPONTANEOUS REGRESSION OF CANCER: THE METABOLIC TRIUMPH OF THE HOST?

1974 • 75 citations

SCLERODERMA IN CARCINOMA

1966 • 74 citations

Increase of lymphocyte‐mediated tumor‐cell destruction by certain patient sera

1973 • 74 citations

Cellular Microcytotoxicity in Human Tumor Systems: Analysis of Results2

1975 • 73 citations

Long-term spontaneous regression of malignant melanoma with visceral metastasesReport of a case with immunologic profile

1975 • 72 citations

Multiple etiologic factors in neoplastic development.

1965 • 70 citations

The Effect of Prolonged Solar Radiation on Melanocytes of the Human Epidermis

1963 • 69 citations

Inhibition of Leukocyte Migration by Tumor-Associated Antigens in Soluble Extracts of Human Malignant Melanoma2

1975 • 67 citations

In Vitro Assays of Cell-Mediated Immunity to Human Solid Tumors: Problems of Quantitation, Specificity, and Interpretation 1

1975 • 66 citations

Antigen Solubilized from Human Solid Tumours: Lymphocyte Stimulation and Cutaneous Delayed Hypersensitivity

1973 • 65 citations

Melanosis Circumscripta Praecancerosa (Dubreuilh)

1960 • 63 citations

Anti-tumor immunoreactivity in patients with malignant melanoma.

1972 • 61 citations

INFECTIOUS DISEASES, TODAY AND TOMORROW

1966 • 59 citations

The genetics of childhood cancer

1975 • 59 citations

Familial Malignant Melanoma

1973 • 57 citations

A clinical, histologic, and immunologic study of a case of metastatic malignant melanoma undergoing spontaneous remission

1976 • 56 citations

Biology of normal and abnormal melanocytes

1971 • 55 citations

Soluble membrane antigens of human malignant melanoma cells

1974 • 55 citations

Antibodies and antigen expression in human melanoma detected by the immune adherence test

1975 • 53 citations

The influence of different isolation procedures and the use of target cells from melanoma cell lines and short‐term cultures on the non‐specific cytotoxic effects of lymphocytes from healthy donors

1975 • 53 citations

Human Malignant Melanoma Antibodies Demonstrated by Immunofluorescence

1970 • 52 citations

Destruction of cultivated melanoma cells by lymphocytes from healthy black (North American Negro) donors

1973 • 51 citations

Intralesional BCG in the treatment of metastatic malignant melanoma

1976 • 51 citations

Specific responsiveness of leukocytes to soluble extracts of human tumors

1975 • 51 citations

Cell-Mediated Immunity to Human Tumors

1973 • 51 citations

The specificity of surface membrane immunofluorescence in human malignant melanoma

1972 • 49 citations

GIANT PIGMENTED NEVI

1959 • 49 citations

Cellular immunity in human malignant melanoma and melanoma histology

1973 • 49 citations

A STUDY ON THE EFFECTS OF IBUPROFEN ON THE METABOLISM OF ANTIPYRINE IN MAN

1973 • 49 citations

Oncornavirus-like particles in human skin cancers.

1975 • 49 citations

Genetic factor in malignant melanoma

1971 • 48 citations

CELL-MEDIATED IMMUNITY IN MALIGNANT MELANOMA

1972 • 48 citations

ULTRASTRUCTURAL DIFFERENCES IN HUMAN MALIGNANT MELANOMATA.

1972 • 48 citations

ANTI‐TUMOUR IMMUNOREACTIVITY IN PATIENTS WITH MALIGNANT MELANOMA

1972 • 46 citations

Evidence for a Tumour-associated Antigen in Human Malignant Melanoma

1973 • 45 citations

Evidence for in vivo Reaction of Antibody and Complement to Surface Antigens of Human Cancer Cells

1974 • 45 citations

Microcytotoxicity and Serum Blocking Factors in Malignant Melanoma and Halo Nevus

1975 • 44 citations

Evidence for tumor-specific immunity in human malignant melanoma

1971 • 42 citations

The immunologic and histopathologic changes of BCG-mediated tumor regression in patients with malignant melanoma

1975 • 41 citations

CELL-MEDIATED IMMUNITY IN PATIENTS WITH MALIGNANT MELANOMA

1972 • 41 citations

Immunology and immunotherapy of human-malignant melanoma: historic review and perspectives for the future.

1975 • 40 citations

Delayed Cutaneous Sensitivity Reactions to Extracts of Autologous Malignant Melanoma: A Second Look<xref ref-type="fn" rid="FN2">2</xref>

1972 • 39 citations

Malignant melanoma and coexisting malignant neoplasms

1971 • 38 citations

Familial Factor in Malignant Melanoma

1965 • 37 citations

IgA as a Blocking Factor in Human Malignant Melanoma

1974 • 36 citations

PRESENCE AND POSSIBLE ROLE OF ANTI-IgG ANTIBODIES IN HUMAN MALIGNANCY

1974 • 35 citations

Cellular immunocompetence in melanoma: effect of extent of disease and immunotherapy

1975 • 35 citations

The Trend of Morality from Primary Malignant Tumors of Skin

1972 • 34 citations

Detection in human melanoma cell lines of particles with some properties in common with RNA tumour viruses

1974 • 34 citations

Cytotoxicity of lymphocytes from healthy subjects and from melanoma patients against cultured melanoma cells.

1975 • 34 citations

Humoral cytotoxicity in melanoma patients and its correlation with the extent and course of the disease

1975 • 33 citations

[Morphology of the epidermal melanin unit].

1969 • 33 citations

Cell-mediated immunity against malignant melanoma in monozygous twins.

1970 • 32 citations

Tumor-associated antigens in human malignant melanoma.

1973 • 32 citations

Combined immunotherapy in malignant melanoma

1976 • 31 citations

Zur Morphologic der epidermalen Melanineinheit

1969 • 31 citations

Virus-like particles in metastases of human malignant melanoma

1972 • 31 citations

The Familial Aspect of Malignant Melanoma

1962 • 30 citations

Tumor-Associated Fetal Antigens in Human Tumors2

1973 • 29 citations

Immunologic studies in patients with malignant melanoma in Uganda.

1969 • 29 citations

Identification of an antigen associated with malignant melanoma

1975 • 29 citations

The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma

1975 • 29 citations

Analysis of soluble melanoma cell membrane antigens in metastatic cells of various organs and further studies of antigens present in primary melanoma

1975 • 28 citations

Immunofluorescent Studies of the Serologic Reactivity of Patients With Malignant Melanoma Against Tumor-Associated Cytoplasmic Antigens23

1974 • 28 citations

Melanoma-Specific Antibodies Produced in Monkeys by Immunization With Human Melanoma Cell Lines2

1973 • 28 citations

Further studies on the ability of regressor sera to block cell‐mediated destruction of rous sarcomas

1974 • 27 citations

Trends in mortality from primary tumours of skin in Canada.

1974 • 26 citations

Primary malignant melanoma of the vagina and vulva.

1974 • 26 citations

Sequentialin vitro reactivity of lymphocytes from melanoma patients receiving immunotherapy compared with the reactivity of lymphocytes from healthy donors

1975 • 24 citations

Tumour‐specific antibody neutralization of factors in rat hepatoma‐bearer serum which abrogate lymph‐node‐cell cytotoxicity

1974 • 24 citations

A Report of Malignant Melanoma of the Skin in Sisters

1961 • 22 citations

Production of antisera with specificity for malignant melanoma and human fetal skin.

1976 • 21 citations

Melanoma in twins.Cutaneous malignant melanoma in identical twins from a set of triplets

1970 • 21 citations

Announcement

1963 • 21 citations

Variables and specificity of in vitro lymphocyte-mediated cytotoxicity in human melanoma.

1975 • 21 citations

Familial Malignant Melanoma

1963 • 21 citations

Humoral and cell-mediated immune response in patients with malignant melanoma.I. In vitro lymphocyte reactivity to pha and antigens following immunization

1975 • 21 citations

Fluorescent Antibody Studies in Malignant Melanoma

1973 • 21 citations

Tumor-Directed Immune Reactivity and Immunotherapy in Malignant Melanoma. Current Status1

2015 • 21 citations

A multiphase immunotherapy regimen for human melanoma: Clinical and laboratory results

1974 • 20 citations

Isolation of a soluble tumor-associated antigen from human melanoma

1976 • 20 citations

Lymphocyte blastogenesis induced by autochthonous human solid tumor cells: Relationship to stage of disease and serum factors

1974 • 20 citations

Lymphocyte blastogenic responses to autochthonous viable and nonviable human tumor cells.

1973 • 19 citations

The specificity of the cytoplasmic antigen in human malignant melanoma

1973 • 19 citations

Primary melanoma of the esophagus

1974 • 19 citations

The significance of humoral antibodies in the localization of human malignant melanoma

1973 • 18 citations

Workshop in human tumor immunology.

1972 • 17 citations

Inhibition of leukocyte migration in agarose by KC1 extracts of a human melanoma cell line grown in serum‐free medium

1975 • 16 citations

Report of a workshop on the immune response to solid tumours in man

1975 • 16 citations

Use of formalin‐fixed melanoma cells for the detection of antibodies against surface antigens by a micro‐immune adherence technique

1975 • 15 citations

Selective and non‐selective lymphocytotoxicity in human melanoma: Observation on the effect of long‐term culture and fetal bovine serum on target‐cell sensitivity to lymphocytes

1975 • 15 citations

Proceedings: Searching for human tumor antigens.

1974 • 14 citations

Delayed cutaneous hypersensitivity reactions to melanoma antigen.

1975 • 12 citations

SPONTANEOUS REGRESSION OF MALIGNANT MELANOMA

1973 • 11 citations

Familial Melanoma

1966 • 11 citations

Effect of bacillus Calmette-Guerin immunotherapy on tumor antigen-induced lymphocyte-stimulated protein synthesis in melanoma patients.

1975 • 11 citations

Lymphocyte toxicity test in clinical melanoma

1973 • 10 citations

Malignant Melanoma in Siblings

1968 • 9 citations

Effects of human sera on reactivity of lymphocytes in microcytotoxicity assays.

1975 • 9 citations

Active specific immunization in malignant melanoma

1975 • 8 citations

TUMOR IMMUNOLOGY WITH PARTICULAR REFERENCE TO MALIGNANT MELANOMA

1975 • 7 citations

Primary melanocarcinoma of the esophagus.

1971 • 7 citations

Distinction of allogeneic immunity from tumor-specific immunity in man.

1974 • 6 citations

The immunology of cancer

1973 • 6 citations

Immunological studies on malignant melanomas of man.

1973 • 5 citations

In vitro testing in tumor immunotherapy.

1974 • 4 citations

Über ungewöhnliche subzelluläre Strukturen eines malignen Melanoms

1971 • 2 citations

Therapeutic implications of cellular immune defects in operable cancer patients revealed by dinitrochlorobenzene skin contact sensitivity.

1975 • 1 citations