Limited Proteolysis as a Tool to Detect Structure and Dynamic Features of Globular Proteins: Studies on Thermolysin

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Turns in Peptides and Proteins

1985 • 1,658 citations

The Preparation of Subtilisin-modified Ribonuclease and the Separation of the Peptide and Protein Components

1959 • 632 citations

Structure of thermolysin refined at 1.6 Å resolution

1982 • 443 citations

Role of proteolytic enzymes in biological regulation (a review).

1976 • 410 citations

The structure of thermolysin: An electron density map at 2.3 Å resolution

1972 • 315 citations

Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).

1986 • 302 citations

Correlation between sites of limited proteolysis and segmental mobility in thermolysin

1986 • 297 citations

Amino-acid Sequence of Thermolysin

1972 • 251 citations

Structural and Functional Aspects of Domain Motions in Proteins

1984 • 246 citations

Folding of Protein Fragments

1981 • 215 citations

Affinity Chromatography and Biological Recognition

1983 • 172 citations

Mapping protein dynamics by X-ray diffraction

1985 • 151 citations

Structural aspects of recognition and assembly in biological macromolecules

1982 • 151 citations

Structures of Two Thermolysin-Inhibitor Complexes That Differ by a Single Hydrogen Bond

1987 • 144 citations

[20] Applications of thermolysin in protein structural analysis

1977 • 97 citations

Amino acid sequence of thermolysin. Isolation and characterization of the fragments obtained by cleavage with cyanogen bromide

1972 • 75 citations

The Structural and Functional Roles of Metal Ions in Thermolysin

1978 • 71 citations

Correlation among sites of limited proteolysis, enzyme accessibility and segmental mobility

1987 • 71 citations

Thermolysin and neutral protease. Mechanistic considerations

1975 • 71 citations

Molecular cartography of globular proteins with application to antigenic sites

1986 • 65 citations

Advances in Protein Sequencing

1981 • 54 citations

Limited proteolysis of thermolysin by subtilisin: isolation and characterization of a partially active enzyme derivative

1985 • 51 citations

Autolysis of thermolysin. Isolation and characterization of a folded three-fragment complex

1986 • 45 citations

SOME GENERAL CONSIDERATIONS ON THE RECOGNITION BY AND OF PROTEINS

1983 • 9 citations