Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics

1979 • 1,136 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Protein normal-mode dynamics: Trypsin inhibitor, crambin, ribonuclease and lysozyme

1985 • 718 citations

DYNAMICS OF PROTEINS: ELEMENTS AND FUNCTION

1983 • 681 citations

Structure and refinement of oxymyoglobin at 1·6 Å resolution

1980 • 641 citations

Thermal vibrations in crystallography

1975 • 625 citations

Correlation between segmental mobility and the location of antigenic determinants in proteins

1984 • 590 citations

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

1984 • 485 citations

Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins

1975 • 474 citations

Crystallographic studies of the dynamic properties of lysozyme

1979 • 437 citations

Packing of α-helices: Geometrical constraints and contact areas

1978 • 366 citations

Three-dimensional structure of an antigen–antibody complex at 6 Å resolution

1985 • 305 citations

Refinement of human lysozyme at 1.5 Å resolution analysis of non-bonded and hydrogen-bond interactions

1981 • 276 citations

Thermal vibrations in crystallography

1976 • 264 citations

Precise determination of the entire antigenic structure of lysozyme: Molecular features of protein antigenic structures and potential of ‘surface-simulation’ synthesis—a powerful new concept for protein binding sites

1978 • 246 citations

Mapping the antigenic epitope for a monoclonal antibody against lysozyme.

1982 • 202 citations

The Atomic Mobility Component of Protein Antigenicity

1985 • 201 citations

A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens

1984 • 150 citations

Topographic antigenic determinants recognized by monoclonal antibodies to sperm whale myoglobin.

1982 • 148 citations

Antigenic regions defined by monoclonal antibodies correspond to structural domains of avian lysozyme.

1984 • 131 citations

ANTIBODIES TO A UNIQUE REGION IN LYSOZYME PROVOKED BY A SYNTHETIC ANTIGEN CONJUGATE

1969 • 124 citations

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1973 • 113 citations

Topographic determinants on cytochrome c. I. The complete antigenic structures of rabbit, mouse, and guanaco cytochromes c in rabbits and mice1.

1977 • 100 citations

The Structural Basis for Antibody Complementary

1978 • 99 citations

A major part of the polypeptide chain of tobacco mosaic virus protein is antigenic

1985 • 90 citations

Internal mobility of ferrocytochrome c

1980 • 85 citations

Efficient generation of antibodies to oncoproteins by using synthetic peptide antigens.

1985 • 73 citations

Influence of solvent accessibility and intermolecular contacts on atomic mobilities in hemerythrins.

1985 • 67 citations

Comparison of the Structures of Various Eukaryotic Ferricytochromes c and Ferrocytochromes and Their Antigenic Differences

1980 • 61 citations

Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides.

1985 • 29 citations

Delineation and conformational analysis of two synthetic peptide models of antigenic sites on rodent cytochrome

1985 • 27 citations

Lattice mobility and anomalous temperature factor behaviour in cytochrome c′

1985 • 20 citations

Automatic recognition of domains in globular proteins

1985 • 15 citations