Analysis of Hepadnavirus Gene Expression, Biology, and Pathogenesis in the Transgenic Mouse

Viral Hepatitis and Liver Disease

1985 • 1,886 citations

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

1985 • 1,069 citations

Progress in Liver Diseases

1965 • 697 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Risk of Cirrhosis and Primary Liver Cancer in Alpha₁-Antitrypsin Deficiency

1986 • 582 citations

Hepatitis B virus DNA contains a glucocorticoid-responsive element.

1986 • 400 citations

Viral Hepatitis and Liver Disease

1989 • 389 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

Replication strategy of human hepatitis B virus

1987 • 314 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Progress in Liver Diseases.

1979 • 261 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation

1987 • 202 citations

Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice.

1990 • 199 citations

Expression and replication of hepatitis B virus genome in transgenic mice.

1989 • 196 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

The acute phase response of the liver in inflammation.

1990 • 171 citations

Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences

1987 • 165 citations

Specific Expression of Hepatitis B Surface Antigen (HBsAg) in Transgenic Mice

1985 • 149 citations

Transcripts and the putative RNA pregenome of duck hepatitis B virus: Implications for reverse transcription

1985 • 143 citations

Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.

1986 • 142 citations

Neonatal Hepatitis Induced by α ₁ -Antitrypsin: a Transgenic Mouse Model

1988 • 139 citations

Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome

1988 • 136 citations

Alcohol and cancer

1986 • 136 citations

Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice.

1987 • 135 citations

Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen.

1987 • 131 citations

The secretory core protein of human hepatitis B virus is expressed on the cell surface

1989 • 130 citations

Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein

1987 • 130 citations

Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant

1985 • 122 citations

Intracellular assembly and packaging of hepatitis B surface antigen particles occur in the endoplasmic reticulum

1986 • 121 citations

Transcription of hepatitis B virus by RNA polymerase II.

1983 • 120 citations

Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis

1986 • 120 citations

Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1.

1989 • 116 citations

Hepatocellular carcinoma in type I glycogen storage disease

1988 • 115 citations

Electron microscopy and immunoelectronmicroscopy of cytoplasmic hepatitis B antigen in hepatocytes.

1974 • 110 citations

Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle.

1986 • 98 citations

Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor.

1988 • 97 citations

Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide

1989 • 93 citations

Chronic ‘Cryptogenic’ Liver Disease and Malignant Hepatoma in Intermediate Alpha_rAntitrypsin Deficiency Identified by a Pi Z-Specific Monoclonal Antibody

1985 • 90 citations

Hepatitis B virus structure and biology

1989 • 88 citations

Transcriptional control elements of hepatitis B surface antigen gene.

1986 • 86 citations

Natural history of woodchuck hepatitis virus infections during the course of experimental viral infection: molecular virologic features of the liver and lymphoid tissues

1989 • 83 citations

Hepatocellular carcinoma in primary biliary cirrhosis: Detection by α-fetoprotein estimation

1984 • 82 citations

Intracellular transport and secretion of hepatitis B surface antigen in mammalian cells

1984 • 81 citations

Hybrid hepatitis B virus-host transcripts in a human hepatoma cell.

1985 • 74 citations

5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles

1987 • 73 citations

Tissue preferential expression of the hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic mice

1988 • 67 citations

X-region-specific transcript in mammalian hepatitis B virus-infected liver

1988 • 62 citations

Distinctive properties of the hepatitis B virus envelope proteins

1988 • 49 citations

Influence of chronic inflammation on the level of mRNA for acute-phase reactants in the mouse liver.

1986 • 48 citations

Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic mice

1989 • 45 citations

HBcAg expressed on the surface of circulating dane particles in patients with hepatitis B virus infection without evidence of anti-HBc formation

1989 • 28 citations

Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse

1989 • 25 citations

Chronic cryptogenic liver disease and malignant hepatoma in intermediate α1-antitrypsin deficiency identified by a PiZ-specific monoclonal antibody

1985 • 25 citations

Negative regulation of the hepatitis B virus pre-S1 promoter by internal DNA sequences

1989 • 25 citations

Demethylation by 5‐Azacytidine Results in the Expression of Hepatitis B Virus Surface Antigen in Transgenic Mice

1989 • 21 citations

Cell type specific expression of pre S 1 antigen and secretion of hepatitis B virus surface antigen

1987 • 20 citations

Viral transcripts in cells infected with defective interfering particles of equine herpesvirus type 1

1989 • 18 citations

Methylation of hepatitis B virus DNA and liver-specific suppression of RNA production in transgenic mouse.

1987 • 16 citations

Transfusion-associated non-A, non-B hepatitis

1988 • 15 citations

DNase I hypersensitive site maps to the HBV enhancer

1989 • 9 citations

Souris transgéniques pour le génome du virus de l'hépatite B

1989 • 1 citations