Insights into Golgi function through mutants in yeast and animal cells

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

1994 • 1,294 citations

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

Coat Proteins and Vesicle Budding

1996 • 955 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum

1994 • 793 citations

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway

1990 • 721 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Quality control in the secretory pathway

1995 • 679 citations

Vesicle fusion from yeast to man

1994 • 635 citations

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

1991 • 604 citations

Implications of the SNARE hypothesis for intracellular membrane topology and dynamics

1994 • 582 citations

Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole

1982 • 579 citations

Coatomer Interaction with Di-Lysine Endoplasmic Reticulum Retention Motifs

1994 • 574 citations

ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway

1990 • 548 citations

The retention signal for soluble proteins of the endoplasmic reticulum

1990 • 531 citations

'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles

1991 • 524 citations

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

1994 • 500 citations

Diffusional Mobility of Golgi Proteins in Membranes of Living Cells

1996 • 499 citations

β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin

1991 • 489 citations

VESICLE-MEDIATED PROTEIN SORTING

1992 • 472 citations

SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER

1993 • 459 citations

PROTEIN GLYCOSYLATION IN YEAST

1987 • 437 citations

Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.

1991 • 415 citations

Retrieval of transmembrane proteins to the endoplasmic reticulum.

1993 • 414 citations

Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum

1992 • 396 citations

An investigation of the role of transmembrane domains in Golgi protein retention.

1995 • 384 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.

1990 • 372 citations

Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides

1995 • 350 citations

The role of clathrin, adaptors and dynamin in endocytosis

1994 • 343 citations

The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.

1995 • 341 citations

β-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo

1993 • 336 citations

Bimodal Interaction of Coatomer with the p24 Family of Putative Cargo Receptors

1996 • 333 citations

Reconstitution of SEC gene product-dependent intercompartmental protein transport

1988 • 332 citations

Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles.

1991 • 318 citations

An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum.

1994 • 315 citations

SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex.

1992 • 311 citations

Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae.

1995 • 310 citations

Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments.

1994 • 304 citations

Stepwise assembly of functionally active transport vesicles

1993 • 298 citations

Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention.

1991 • 296 citations

Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.

1996 • 284 citations

Kin recognition between medial Golgi enzymes in HeLa cells.

1994 • 278 citations

COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast

1995 • 278 citations

Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy.

1992 • 278 citations

Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae.

1991 • 268 citations

Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast.

1994 • 265 citations

Parallel secretory pathways to the cell surface in yeast.

1995 • 257 citations

Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation.

1989 • 249 citations

Localization of components involved in protein transport and processing through the yeast Golgi apparatus.

1991 • 247 citations

The ERD2 gene determines the specificity of the luminal ER protein retention system

1990 • 243 citations

A novel adaptor-related protein complex.

1996 • 241 citations

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.

1995 • 229 citations

HVEM tomography of the trans-Golgi network: structural insights and identification of a lace-like vesicle coat.

1994 • 229 citations

Heterogeneous distribution of filipin--cholesterol complexes across the cisternae of the Golgi apparatus.

1981 • 225 citations

Kin recognition

1993 • 223 citations

Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol

1993 • 218 citations

Assembly of the ER to Golgi SNARE complex requires Uso1p.

1996 • 203 citations

SNARE-Mediated Retrograde Traffic from the Golgi Complex to the Endoplasmic Reticulum

1996 • 201 citations

The Role of GTP-Binding Proteins in Transport Along the Exocytic Pathway

1993 • 199 citations

SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer

1992 • 198 citations

Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm.

1991 • 196 citations

Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo

1994 • 190 citations

Beta-COP localizes mainly to the cis-Golgi side in exocrine pancreas.

1993 • 190 citations

A role for phosphatidylinositol transfer protein in secretory vesicle formation

1995 • 186 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

1995 • 184 citations

Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae

1993 • 183 citations

Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.

1995 • 183 citations

Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p.

1995 • 182 citations

GENETIC ANALYSIS OF THE YEAST CYTOSKELETON

1987 • 179 citations

The Golgi-localization of yeast Emp47p depends on its di-lysine motif but is not affected by the ret1-1 mutation in alpha-COP.

1995 • 175 citations

Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins

1993 • 174 citations

Sorting of membrane proteins in the secretory pathway

1993 • 171 citations

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes

1994 • 169 citations

Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: studies with cholera toxin in Vero cells.

1996 • 166 citations

The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity.

1995 • 150 citations

Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues.

1993 • 148 citations

Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae.

1992 • 147 citations

Transport into and out of the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase.

1994 • 147 citations

Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport.

1996 • 142 citations

Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP.

1994 • 139 citations

GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles.

1996 • 139 citations

Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval.

1996 • 138 citations

Genetic and biochemical analysis of vesicular traffic in yeast

1992 • 138 citations

Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.

1994 • 137 citations

Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain.

1996 • 136 citations

Beta-COP is essential for transport of protein from the endoplasmic reticulum to the Golgi in vitro

1993 • 133 citations

The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack.

1995 • 129 citations

COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p.

1996 • 122 citations

ERGIC-53, a Membrane Protein of the Endoplasmic Reticulum-Golgi Intermediate Compartment, Is Identical to MR60, an Intracellular Mannose-specific Lectin of Myelomonocytic Cells

1995 • 121 citations

Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway.

1995 • 120 citations

Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.

1996 • 120 citations

Cloning and functional characterization of mammalian homologues of the COPII component Sec23.

1996 • 117 citations

About turn for the COPs?

1994 • 114 citations

Targeting and retention of Golgi membrane proteins

1993 • 110 citations

Biogenesis of the Vacuole in Saccharomyces cerevisiae

1992 • 108 citations

Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum.

1995 • 105 citations

Protein transport to the yeast vacuole

1995 • 102 citations

Sorting by COP I-coated vesicles under interphase and mitotic conditions.

1996 • 97 citations

[13] Reconstitution of transport from endoplasmic reticulum to golgi complex using endoplasmic reticulum-enriched membrane fraction from yeast

1992 • 97 citations

A galactosyltransferase from the fission yeast Schizosaccharomyces pombe.

1989 • 96 citations

[45] Analysis of polypeptide transit through yeast secretory pathway

1991 • 96 citations

Sorting of membrane proteins in the yeast secretory pathway.

1994 • 95 citations

Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes.

1996 • 92 citations

Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particle.

1991 • 91 citations

The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway.

1994 • 90 citations

Chapter 1 A Hitchhiker's Guide to Analysis of the Secretory Pathway in Yeast

1989 • 88 citations

SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation.

1995 • 86 citations

THE NITROGENOUS CONSTITUENTS OF PLANTS

1947 • 84 citations

The Newly Identified Yeast GRD Genes Are Required for Retention of Late-Golgi Membrane Proteins

1996 • 81 citations

Yeast KEX2 protease and mannosyltransferase I are localized to distinct compartments of the secretory pathway

1989 • 81 citations

A comparison of the transmembrane domains of Golgi and plasma membrane proteins

1995 • 73 citations

The role of coat proteins in the biosynthesis of secretory proteins

1995 • 73 citations

Golgi Localization in Yeast Is Mediated by the Membrane Anchor Region of Rat Liver Sialyltransferase

1995 • 72 citations

Modulation of the Golgi apparatus in Saccharomyces cerevisiae sec7 mutants as seen by three‐dimensional electron microscopy

1993 • 70 citations

Distinct coated vesicles labeled for p200 bud from trans-Golgi network membranes.

1995 • 68 citations

Enzymes involved in mammalian oligosaccharide biosynthesis

1994 • 67 citations

Phospholipid metabolism and membrane dynamics

1996 • 57 citations

Genome sequencing: The complete code for a eukaryotic cell

1996 • 55 citations

Coatomer-rich endoplasmic reticulum.

1994 • 48 citations

Dynamic retention of TGN membrane proteins in Saccharomyces cerevisiae

1993 • 48 citations

Mitotic disassembly of the mammalian Golgi apparatus

1995 • 33 citations

Purification and characterization of a late Golgi compartment from Saccharomyces cerevisiae.

1994 • 29 citations

Probing the mobility of membrane proteins inside the cell

1996 • 14 citations

[26] Use of sec mutants to define intermediates in protein transport from endoplasmic reticulum

1992 • 6 citations

Deleted Work

1955 • 0 citations