Alcohol-Induced Changes in Neuronal Membranes
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Abstract
References (227)
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Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels
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Pressure Reversal of Anaesthesia
1971 • 252 citations
Increased cholesterol content of erythrocyte and brain membranes in ethanol-tolerant mice
1978 • 248 citations
Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor.
1989 • 237 citations
Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects
1985 • 236 citations
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Chronic ethanol causes heterologous desensitization of receptors by reducing αsmessenger RNA
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Calcium channel antagonists decrease the ethanol withdrawal syndrome
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1990 • 217 citations
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1981 • 204 citations
Inhibition of synaptosomal calcium uptake by ethanol.
1980 • 203 citations
Increased dihydropyridine-sensitive calcium channels in rat brain may underlie ethanol physical dependence
1987 • 203 citations
Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression.
1992 • 200 citations
Volatile general anaesthetics activate a novel neuronal K+ current
1988 • 199 citations
Ethanol regulates calcium channels in clonal neural cells.
1986 • 197 citations
Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells.
1991 • 195 citations
Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits
1992 • 188 citations
Chronic ethanol administration alters gamma-aminobutyric acid, pentobarbital and ethanol-mediated 36Cl- uptake in cerebral cortical synaptoneurosomes.
1988 • 184 citations
Tolerance and Cross-Tolerance in Chronic Alcoholics: Reduced Membrane Binding of Ethanol and Other Drugs
1981 • 184 citations
Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization
1984 • 180 citations
Ethanol and the physical properties of brain membranes: fluorescence studies.
1981 • 180 citations
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Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.
1985 • 175 citations
G proteins: implications for psychiatry
1992 • 172 citations
Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients.
1987 • 170 citations
Prolonged ethanol inhalation decreases gamma-aminobutyric acidA receptor alpha subunit mRNAs in the rat cerebral cortex.
1991 • 169 citations
Synaptosomal membrane lipids of mice during continuous exposure to ethanol
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Membranes and phospholipids of liver mitochondria from chronic alcoholic rats are resistant to membrane disordering by alcohol.
1981 • 164 citations
Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site
1989 • 160 citations
Inhibition of fast- and slow-phase depolarization-dependent synaptosomal calcium uptake by ethanol.
1983 • 158 citations
Thermodynamic reversibility of phase transitions. Specific effects of alcohols on phosphatidylcholines
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Phosphatidylethanol formation in rat organs after ethanol treatment
1984 • 157 citations
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Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia.
1986 • 154 citations
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An abnormal phospholipid in rat organs after ethanol treatment
1983 • 150 citations
Physical properties and lipid composition of brain membranes from ethanol tolerant-dependent mice.
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1937 • 146 citations
Mechanisms of general anesthesia.
1990 • 142 citations
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1975 • 129 citations
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1991 • 126 citations
Ethanol Tolerance in the Rat Is Learned
1981 • 123 citations
Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquillisers
1975 • 120 citations
Ethanol differentially regulates G proteins in neural cells
1988 • 119 citations
Chronic Ethanol Treatment Alters Brain Levels of γ‐Aminobutyric AcidA Receptor Subunit mRNAs: Relationship to Genetic Differences in Ethanol Withdrawal Seizure Severity
1991 • 117 citations
Sensitivity to ethanol in inbred mice: Genotypic correlations among several behavioral responses.
1983 • 115 citations
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1986 • 113 citations
Effects of pertussis toxin treatment on the metabolism of rat adipocytes.
1983 • 112 citations
Is membrane expansion relevant to anaesthesia?
1981 • 108 citations
Activation of adenylate cyclase by alcohols requires the nucleotide-binding protein.
1984 • 106 citations
Characterization of Acute and Chronic Tolerance in Mice Selected for Inherent Differences in Sensitivity to Ethanol
1980 • 104 citations
Sensitivity to ethanol in inbred mice: Genotypic correlations among several behavioral responses.
1983 • 103 citations
General anesthetics expand cell membranes at surgical concentrations
1972 • 102 citations
PRESSURE REVERSAL OF GENERAL ANAESTHESIA—A MULTI-SITE EXPANSION HYPOTHESIS
1978 • 100 citations
Are changes in neuronal calcium channels involved in ethanol tolerance?
1989 • 98 citations
Lipid fluidity directly modulates the overall protein rotational mobility of the Ca-ATPase in sarcoplasmic reticulum.
1988 • 97 citations
Ethanol disordering of spin-labeled mouse brain membranes: correlation with genetically determined ethanol sensitivity of mice.
1982 • 96 citations
Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function.
1993 • 96 citations
Possible association of alcohol tolerance with increased synaptic Ca2+ sensitivity
1983 • 96 citations
Adenosine is required for ethanol-induced heterologous desensitization.
1989 • 96 citations
Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: Role of the “G proteins” in stimulus-response coupling
1985 • 92 citations
Membrane Disordering by Anesthetic Drugs: Relationship to Synaptosomal Sodium and Calcium Fluxes
1985 • 91 citations
Pressure reversal of the action of certain narcotics
1942 • 91 citations
Pressure Reversal of Inhilation Anesthetic-Induced Disorder in Spin-Labeled Phospholipid Vesicles
1973 • 91 citations
Lipid domains and the relationship to membrane function
1988 • 90 citations
Membrane fluidity is not an important physiological regulator of the (Ca2+-Mg2+)-dependent ATPase of sarcoplasmic reticulum.
1984 • 90 citations
Membrane effects of ethanol: Bulk lipid versus lipid domains
1988 • 90 citations
Alterations in Phospholipid Composition in Ethanol Tolerance and Dependence
1979 • 90 citations
Multiple sites of action of ethanol on adenylate cyclase.
1983 • 88 citations
Role of Hydrogen Bonding in General Anesthesia
1991 • 86 citations
Role of phosphatidylethanol in membranes. Effects on membrane fluidity, tolerance to ethanol, and activity of membrane-bound enzymes
1991 • 86 citations
Pharmacologic significance of the structural heterogeneity of the GABAA receptor-chloride ion channel complex.
1991 • 85 citations
Effects of chronic ethanol administration on the composition of membrane lipids in the mouse
1982 • 84 citations
Mechanisms of neuronal adaptation to ethanol. Ethanol induces Hsc70 gene transcription in NG108-15 neuroblastoma x glioma cells
1991 • 84 citations
Neurochemical actions of anesthetic drugs on the gamma-aminobutyric acid receptor-chloride channel complex.
1987 • 83 citations
Augmentation by calcium channel antagonists of general anaesthetic potency in mice
1986 • 82 citations
Transbilayer effects of ethanol on fluidity of brain membrane leaflets
1988 • 82 citations
Asymmetric distribution of a fluorescent sterol in synaptic plasma membranes: effects of chronic ethanol consumption
1990 • 82 citations
Formation of fatty acid ethyl esters during chronic ethanol treatment in mice
1988 • 82 citations
Effect of ethanol on intracellular ionized calcium concentrations in synaptosomes and hepatocytes.
1987 • 80 citations
GTP-binding proteins as possible targets for protein kinase C action
1989 • 79 citations
The perturbation of lipid bilayers by general anesthetics: a quantitative test of the disordered lipid hypothesis.
1980 • 77 citations
Ethanol and the γ‐Aminobutyric Acid‐Benzodiazepine Receptor Complex
1984 • 75 citations
THE PHYSIOLOGICAL EFFECTS OF PRESSURE
1936 • 75 citations
The GTPase superfamily
1993 • 75 citations
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
1993 • 73 citations
Nonanesthetic alcohols dissolve in synaptic membranes without perturbing their lipids.
1989 • 72 citations
Ethanol-induced changes in neuronal membrane order. An NMR study
1986 • 68 citations
Effect of ethanol on electrolyte transport and electrogenesis in animal tissues
1965 • 68 citations
Evidence for down-regulation of 3H-nitrendipine recognition sites in mouse brain after long-term treatment with nifedipine or verapamil
1985 • 67 citations
Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism.
1988 • 65 citations
Changes in cortical synaptosomal plasma membrane fluidity and composition in ethanol-dependent rats
1983 • 62 citations
Hormonal Tolerance to Ethanol is Associated with Decreased Expression of the GTP‐Binding Protein, Gsα, and Adenylyl Cyclase Activity in Ethanol‐Treated LS Mice
1991 • 62 citations
Biophysical and biochemical alterations in erythrocyte membranes from chronic alcoholics
1991 • 62 citations
Biochemical and behavioral effects of acute ethanol in rats at different environmental temperatures
1981 • 59 citations
Effects of ethanol on 45Ca2+ uptake in synaptosomes and in PC12 cells
1987 • 58 citations
Cellular Effects of Alcohol; A Review
1970 • 55 citations
Ethanol and neuronal calcium channels
1990 • 53 citations
Ethanol and inositol 1,4,5-trisphosphate release calcium from separate stores of brain microsomes.
1989 • 52 citations
Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes
1983 • 51 citations
Influence of alcohols, temperature, and region on the mobility of lipids in neuronal membrane
1987 • 50 citations
Alterations in brain lipid composition of mice made physically dependent to ethanol
1982 • 50 citations
Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal
1991 • 50 citations
Molecular Mechanism of Ethanol Metabolism by Human Brain to Fatty Acid Ethyl Esters
1993 • 50 citations
Enhanced Expression of the Inhibitory Protein Gi2α and Decreased Activity of Adenylyl Cyclase in Lymphocytes of Abstinent Alcoholics
1993 • 49 citations
Ethanol increases receptor-dependent cyclic AMP production in cultured hepatocytes by decreasing Gi-mediated inhibition
1992 • 48 citations
Hans Horst Meyer and the lipoid theory of narcosis
1989 • 48 citations
Ethanol increases synaptosomal free calcium concentration
1988 • 47 citations
G Proteins in Signal Transduction: The Regulation of Phospholipase C
2007 • 46 citations
Support for the shape concept of lipid structure based on a headgroup volume approach
1993 • 46 citations
Lack of Correlation Between Hepatic Mitochondrial Membrane Structure and Functions in Ethanol-Fed Rats
1982 • 46 citations
GABAergic Synaptic Transmission: Molecular, Pharmacological, and Clinical Aspects
1993 • 45 citations
Phosphatidylinositol from ethanol-fed rats confers membrane tolerance to ethanol.
1986 • 45 citations
Effects of Chronic Ethanol Treatment on Lipid Composition and Prostaglandins in Rats Fed Essential Fatty Acid Deficient Diets
1984 • 44 citations
Increased acidic phospholipids in rat brain membranes after chronic ethanol administration
1984 • 44 citations
Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors.
1990 • 43 citations
Inhibition of fast phase calcium uptake and endogenous norepinephrine release in rat brain region synaptosomes by ethanol
1986 • 43 citations
Influence of ethanol on calcium, inositol phospholipids and intracellular signalling mechanisms
1989 • 42 citations
Hyperbaric ethanol antagonism: Role of temperature, blood and brain ethanol concentrations
1982 • 42 citations
The Role of Adenosine and Adenosine Transport in Ethanol‐Induced Cellular Tolerance and Dependence
1991 • 41 citations
Species variation and the mechanism of pressure–anaesthetic interactions
1984 • 40 citations
Regulation of glutamate receptors: possible role of phosphatidylserine
1982 • 39 citations
Effect of ethanol on cyclic AMP levels in intact PC12 cells
1990 • 38 citations
Regulation of Mammalian Adenylyl Cyclases by G-Protein and Subunits
1992 • 38 citations
Temperature dependence of ethanol depression: Linear models in male and female mice
1985 • 35 citations
Drug and Anesthetic Effects on Membrane Structure and Function
1992 • 35 citations
Effects of in vivo ethanol administration on Ca2+/Mg2+ ATPase and ATP-dependent Ca2+ uptake activity in synaptosomal membranes
1983 • 33 citations
Phosphatidylethanol Affects Inositol 1,4,5‐Trisphosphate Levels in NG108‐15 Neuroblastoma × Glioma Hybrid Cells
1993 • 33 citations
The effect of chronic ethanol administration on lipids and fatty acids in subcellular fractions of rat brain.
1982 • 33 citations
Ethanol differentially regulates guanine nucleotide-binding protein alpha subunit expression in NG108-15 cells independently of extracellular adenosine.
1993 • 32 citations
Pressure Reversal of Anesthesia: The Extent of Small-molecule Exclusion from Spin-labeled Phospholipid Model Membranes
1973 • 32 citations
Cell signalling: Dual control of adenylate cyclase
1983 • 32 citations
Enhancement of opiate binding by various molecular forms of phosphatidylserine and inhibition by other unsaturated lipids
1977 • 32 citations
G Proteins Coupled to Phospholipase C: Molecular Targets of Long‐Term Ethanol Exposure
1991 • 30 citations
Mechanism of Fatty Acid Ethyl Ester Formation and Biological Significance
1991 • 30 citations
Alkylation of striatal dopamine receptors abolishes stereotyped behavior but has no effect on dopamine stimulated adenylate cyclase activity
1988 • 29 citations
Hyperbaric ethanol antagonism in mice: Studies on oxygen, nitrogen, strain and sex
1982 • 29 citations
Potentiation of γ‐Aminobutyric Acid‐Mediated Chloride Flux by Pentobarbital and Diazepam but Not Ethanol
1992 • 29 citations
Comparison of Voltage‐Dependent 45Ca2+ Uptake Rates by Synaptosomes Isolated from Rat Brain Regions
1983 • 29 citations
Drug and anesthetic effects on membrane structure and function
1991 • 29 citations
Interfacial dehydration by alcohols: hydrogen bonding of alcohols to phospholipids
1991 • 29 citations
Determination of ethanol partition coefficients to the interior and the surface of dipalmityl-phosphatidylcholine liposomes using deuterium nuclear magnetic resonance spectroscopy
1985 • 27 citations
Ethanol and synaptosomal calcium homeostasis
1990 • 27 citations
Low-Level Hyperbaric Ethanol Antagonism in Mice
1981 • 27 citations
Increase of Na+K+ ATPase activity in intact rat brain synaptosomes after their interaction with phosphatidylserine vesicles
1981 • 26 citations
RNA Structure from A to Z
1987 • 25 citations
Ethanol Withdrawal in Mice Precipitated and Exacerbated by Hyperbaric Exposure
1985 • 25 citations
Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl− influx
1989 • 24 citations
Factors in Ethanol Tolerance
1984 • 23 citations
Effects of Ethanol on Structural Parameters of Rat Brain Membranes: Relationship to Genetic Differences in Ethanol Sensitivity
1994 • 22 citations
Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cells
1991 • 22 citations
The Effects of Ethanol on Polyunsaturated Fatty Acid Composition
1993 • 22 citations
Phosphatidylethanol Formation in Rat Hepatocytesa
1991 • 22 citations
Body temperature differentially affects ethanol sensitivity in both inbred strains and selected lines of mice.
1990 • 22 citations
The Role of Calcium Flux in the Central Nervous System Actions of Ethanol
1991 • 21 citations
Ambient temperature and the development of functional tolerance to ethanol by mice
1979 • 21 citations
GABAergic synaptic transmission : molecular, pharmacological, and clinical aspects
1992 • 21 citations
Cholesterol Exchange and Lateral Cholesterol Pools in Synaptosomal Membranes of Pair‐Fed Control and Chronic Ethanol‐Treated Mice
1993 • 21 citations
Temperature dependence of ethanol depression in rats
1986 • 21 citations
Effects of ethanol on ouabain inhibition of mouse brain (Na+,K+)ATPase activity
1987 • 21 citations
Polyunsaturated Fatty Acids and Ethanol
1988 • 20 citations
Antagonism of Ethanol Narcosis in Mice by Hyperbaric Pressures of 4–8 Atmospheres
1980 • 20 citations
From binding studies to the molecular biology of GABA receptors
1990 • 20 citations
Resistance to ethanol disordering of membranes from ethanol-fed rats is conferred by all phospholipid classes
1992 • 19 citations
Ethanol and inositol 1,4,5-trisphosphate mobilize calcium from rat brain microsomes
1989 • 19 citations
Significance of ethanol-induced changes in membrane lipid domains.
1991 • 18 citations
Calcium and Glycoprotein Metabolism as Correlates for Ethanol Preference and Sensitivity
1979 • 16 citations
Chronic Ethanol Reduces Immunologically Detectable Gqα/11α in NG108–15 Cells
1993 • 16 citations
Interaction of Amphiphilic Molecules with Biological Membranes
1985 • 15 citations
Effects of Chronic Ethanol Exposure on Cardiac Receptor-Adenylyl Cyclase Coupling: Studies in Cultured Embryonic Chick Myocytes and Ethanol Fed Rats
1991 • 14 citations
Brain lipid changes after ethanol exposure.
1990 • 13 citations
Chronic ethanol consumption alters transbilayer distribution of phosphatidylcholine in erythrocytes of Sinclair (S-1) miniature swine
1991 • 13 citations
Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture
1990 • 13 citations
Ethanol-induced depression of aggression in mice antagonized by hyperbaric exposure
1991 • 12 citations
Alterations of Metabolites in the Nervous System
1985 • 11 citations
Differential effects of ethanol on the striatal and cortical adenylate cyclase system.
1987 • 11 citations
Interaction of amphiphilic molecules with biological membranes. A model for nonspecific and specific drug effects with membranes.
1985 • 11 citations
Rat cerebral cortical synaptoneurosomal membranes. Structure and interactions with imidazobenzodiazepine and 1,4-dihydropyridine calcium channel drugs
1990 • 10 citations
Lack of effect of acute alcohol ingestion on erythrocyte Na+, K+ -ATPase activity or passive sodium uptake in vivo in man.
1986 • 9 citations
Anionic glycerophospholipids in platelets from alcoholics
1986 • 9 citations
Ligand-dependent effects of ethanol and diethylether at brain benzodiazepine receptors
1992 • 8 citations
Differences in the Plasma Membrane Proteins of Chronic Alcoholic Rat Brain
1990 • 7 citations
Distinct effects of phosphatidylethanol on three types of rat brain protein kinase C.
1989 • 6 citations
Biochemical, immunological, and pharmacological characterization of GABAA-benzodiazepine receptor subtypes.
1992 • 6 citations
Alcohol
1985 • 4 citations
ACIDIC PHOSPHOLIPIDS IN SYNAPTOSOMAL PLASMA MEMBRANES DURING REPEATED EPISODES OF PHYSICAL ETHANOL DEPENDENCE IN THE RAT
1991 • 4 citations
The Effects of Low Level Hyperbaric Treatment on Acute Ethanol Intoxication
1980 • 4 citations
Rats withdrawn from ethanol rapidly re-acquire membrane tolerance after resumption of ethanol feeding
1990 • 3 citations
Phosphatidylserine vesicles increase rat brain synaptosomal adenylate cyclase activity
1987 • 3 citations