Molecular Systematics at the Species Boundary: Exploiting Conserved and Variable Regions of the Mitochondrial Genome of Animals via Direct Sequencing from Amplified DNA

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

1980 • 28,067 citations

Molecular Evolutionary Genetics

1987 • 15,266 citations

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

Evolution of Protein Molecules

1969 • 11,042 citations

Mathematical model for studying genetic variation in terms of restriction endonucleases.

1979 • 10,442 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Dating of the human-ape splitting by a molecular clock of mitochondrial DNA

1985 • 8,642 citations

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.

1989 • 4,904 citations

Rapid evolution of animal mitochondrial DNA.

1979 • 3,420 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

INTRASPECIFIC PHYLOGEOGRAPHY: The Mitochondrial DNA Bridge Between Population Genetics and Systematics

1987 • 3,210 citations

Mammalian Protein Metabolism

1964 • 3,199 citations

Mitochondrial DNA and human evolution

1987 • 2,967 citations

Quantitative Phyletics and the Evolution of Anurans

1969 • 2,905 citations

The Mammals of North America

1959 • 2,598 citations

Quantitative Phyletics and the Evolution of Anurans

1969 • 2,320 citations

Evolution of the cytochromeb gene of mammals

1991 • 2,289 citations

PHYLOGENIES FROM MOLECULAR SEQUENCES: INFERENCE AND RELIABILITY

1988 • 2,143 citations

Time Warps, String Edits, and Macromolecules: The Theory and Practice of Sequence Comparison

1983 • 1,947 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Sequence and gene organization of mouse mitochondrial DNA

1981 • 1,712 citations

Mitochondrial DNA sequences of primates: Tempo and mode of evolution

1982 • 1,578 citations

PHYLOGENETIC INFERENCE FROM RESTRICTION ENDONUCLEASE CLEAVAGE SITE MAPS WITH PARTICULAR REFERENCE TO THE EVOLUTION OF HUMANS AND THE APES

1983 • 1,519 citations

Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome

1982 • 1,491 citations

The mitochondrial DNA molecule ofDrosophila yakuba: Nucleotide sequence, gene organization, and genetic code

1985 • 1,484 citations

EVOLUTION OF ANIMAL MITOCHONDRIAL DNA: RELEVANCE FOR POPULATION BIOLOGY AND SYSTEMATICS

1987 • 1,484 citations

Flowering Plants of the World

1978 • 1,398 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Molecular systematics

1991 • 1,372 citations

A Successive Approximations Approach to Character Weighting

1969 • 1,292 citations

Mitochondrial DNA and two perspectives on evolutionary genetics

1985 • 1,260 citations

Sequence and gene organization of the chicken mitochondrial genome

1990 • 1,086 citations

A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.

1985 • 1,064 citations

Compilation of small ribosomal subunit RNA sequences

1992 • 985 citations

The cichlid fishes of the great lakes of Africa: their biology and evolution,

1972 • 979 citations

Complementary base pairing and the origin of substitution mutations

1976 • 835 citations

A Framework for the Quantitative Study of Evolutionary Trees

1989 • 833 citations

Molecular Phylogeny of the Animal Kingdom

1988 • 743 citations

The complete nucleotide sequence of the Xenopus laevis mitochondrial genome.

1985 • 741 citations

Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia.

1989 • 637 citations

Animal mitochondrial DNA as a genetic marker in population and evolutionary biology

1989 • 634 citations

PHYLOGENETIC RELATIONSHIPS OF MITOCHONDRIAL DNA UNDER VARIOUS DEMOGRAPHIC MODELS OF SPECIATION11Work was supported by an NIH predoctoral fellowship to JEN, and by NSF Grant BSR-8217291.

1986 • 623 citations

The Cichlid Fishes of the Great Lakes of Africa. Their Biology and Evolution

1973 • 616 citations

The guanine and cytosine content of genomic DNA and bacterial evolution.

1987 • 587 citations

Chloroplast DNA Variation and Plant Phylogeny

1988 • 567 citations

Proceedings of the Michigan Morphometrics Workshop.

1992 • 566 citations

Reconstructing ancestral character states under Wagner parsimony

1987 • 563 citations

The Mitochondrial Genome of Animals

1985 • 559 citations

The use of restriction endonucleases to measure mitochondrial DNA sequence relatedness in natural populations

1981 • 554 citations

The complete nucleotide sequence of theRattus norvegicus mitochondrial genome: Cryptic signals revealed by comparative analysis between vertebrates

1989 • 523 citations

COULD A CLADOGRAM THIS SHORT HAVE ARISEN BY CHANCE ALONE?: ON PERMUTATION TESTS FOR CLADISTIC STRUCTURE

1991 • 508 citations

An examination of the constancy of the rate of molecular evolution

1974 • 483 citations

Tempo and mode of sequence evolution in mitochondrial DNA of HawaiianDrosophila

1987 • 478 citations

An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution

1970 • 469 citations

Insects Of Hawaii

1948 • 455 citations

An evaluation of the molecular clock hypothesis using mammalian DNA sequences

1987 • 453 citations

Compositional constraints and genome evolution

1986 • 451 citations

HUMAN MITOCHONDRIAL DNA VARIATION AND EVOLUTION: ANALYSIS OF NUCLEOTIDE SEQUENCES FROM SEVEN INDIVIDUALS

1983 • 449 citations

Secondary Structure of 16 S Ribosomal RNA

1981 • 446 citations

Isozymes. Current Topics in Biological and Medical Research

1982 • 444 citations

Flowering Plants of the World

1994 • 441 citations

A Randomization Test for Phylogenetic Information in Systematic Data

1989 • 377 citations

Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

1984 • 369 citations

POLYMORPHIC SITES AND THE MECHANISM OF EVOLUTION IN HUMAN MITOCHONDRIAL DNA

1984 • 365 citations

The Application of Electrophoretic Data in Systematic Studies

1984 • 362 citations

A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides

1986 • 351 citations

Nucleotide sequence and gene organization of sea urchin mitochondrial DNA

1988 • 334 citations

Isozymes current topics in biological and medical research

1984 • 328 citations

Molecules and morphology in evolution: Conflict or compromise?

1988 • 326 citations

The Retention Index and Homoplasy Excess

1989 • 323 citations

Nuclear and Mitochondrial DNA Comparisons Reveal Extreme Rate Variation in the Molecular Clock

1986 • 315 citations

Origin and Evolution of Mitochondrial DNA

1989 • 311 citations

On the rate of DNA sequence evolution inDrosophila

1989 • 300 citations

Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code

1983 • 300 citations

Compilation of small ribosomal subunit RNA sequences

1990 • 279 citations

Bizarre tRNAs inferred from DNA sequences of mitochondrial genomes of nematode worms.

1987 • 272 citations

Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons

1987 • 271 citations

Inferring Evolutionary Trees from Gene Frequency Data Under the Principal of Maximum Parsimony

1987 • 263 citations

The alignment of sets of sequences and the construction of phyletic trees: An integrated method

1984 • 261 citations

Mapping of mitochondrial DNA of individual sheep and goats: Rapid evolution in the D loop region

1977 • 250 citations

Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

1988 • 247 citations

Mitochondrial DNA in the bark weevils: size, structure and heteroplasmy.

1989 • 242 citations

Paired sequence difference in ribosomal RNAs: evolutionary and phylogenetic implications.

1988 • 238 citations

Homoplasy Excess Ratios: New Indices for Measuring Levels of Homoplasy in Phylogenetic Systematics and a Critique of the Consistency Index

1989 • 210 citations

A comparison of the small ribosomal RNA genes from the mitochondrial DNA of the great apes and humans: sequence, structure, evolution, and phylogenetic implications.

1986 • 210 citations

Taxonomy with confidence

1978 • 209 citations

The Complete Nucleotide Sequence, Gene Organization, and Genetic Code of the Mitochondrial Genome of Paracentrotus lividus

1989 • 207 citations

Compilation of small ribosomal subunit RNA sequences

1988 • 206 citations

LENGTH MUTATIONS IN HUMAN MITOCHONDRIAL DNA

1983 • 205 citations

EVOLUTION OF RIBOSOMAL DNA: FIFTY MILLION YEARS OF RECORDED HISTORY IN THE FROG GENUS RANA

1986 • 203 citations

The Evolutionary Biology of the Hawaiian Drosophilidae

1970 • 202 citations

Spatial and temporal continuity of kangaroo rat populations shown by sequencing mitochondrial DNA from museum specimens

1990 • 198 citations

Molecular population genetics of mtDNA size variation in crickets.

1989 • 190 citations

Evolutionary Processes and Theory.

1988 • 185 citations

The Polymerase Chain Reaction: DNA Extraction and Amplification

1991 • 180 citations

Molecules and Morphology in Evolution: Conflict or Compromise?

1988 • 180 citations

Molecular phylogeny and evolution of primate mitochondrial DNA.

1988 • 179 citations

A new method that simultaneously aligns and reconstructs ancestral sequences for any number of homologous sequences, when the phylogeny is given.

1989 • 178 citations

Cladistic Analysis of Restriction Endonuclease Cleavage Maps within a Maximum-likelihood Framework

1985 • 174 citations

Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations.

1988 • 169 citations

Decoding the pattern of protein evolution

1981 • 168 citations

Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication

1979 • 168 citations

[53] Phylogenetic analysis using ribosomal RNA

1988 • 167 citations

The CO-I and CO-II region of honeybee mitochondrial DNA: evidence for variation in insect mitochondrial evolutionary rates.

1989 • 167 citations

Mitochondrial DNA evolution in themelanogaster species subgroup ofDrosophila

1986 • 165 citations

Variation in salmonid mitochondrial DNA: Evolutioinary constraints and mechanisms of substitution

1989 • 164 citations

Molecular clock of silent substitution: At least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes

1982 • 154 citations

Drosophila mitochondrial DNA: Conserved sequences in the A+T-rich region and supporting evidence for a secondary structure model of the small ribosomal RNA

1987 • 148 citations

Man's place in Hominoidea as inferred from molecular clocks of DNA

1987 • 145 citations

[34] Converting distance to time: Application to human evolution

1990 • 138 citations

Rates of nucleotide substitution in Drosophila mitochondrial DNA and nuclear DNA are similar.

1986 • 137 citations

On the Overdispersed Molecular Clock

1987 • 133 citations

SEQUENCE EVOLUTION OF DROSOPHILA MITOCHONDRIAL DNA

1985 • 128 citations

The phylogeny of human globin genes investigated by the maximum parsimony method

1974 • 125 citations

FOUNDER EFFECTS AND THE RATE OF MITOCHONDRIAL DNA EVOLUTION IN HAWAIIAN DROSOPHILA

1988 • 116 citations

Discordance of nuclear and mitochondrial DNA phylogenies in Hawaiian Drosophila.

1986 • 113 citations

Polymerase Chain Reaction

2016 • 107 citations

Cladistic Analysis of Restriction Endonuclease Cleavage Maps Within a Maximum-Likelihood Framework

1985 • 101 citations

Transitions and transversions in evolutionary descent: An approach to understanding

1983 • 93 citations

Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hybridization of four-nucleotide-recognizing restriction enzyme digests.

1986 • 93 citations

Inferring the number of evolutionary events from DNA coding sequence differences.

1989 • 87 citations

Estimating genetic divergence and genetic variability with restriction endonucleases.

1981 • 87 citations

DIFFERING LEVELS OF AMONG‐POPULATION DIVERGENCE IN THE MITOCHONDRIAL DNA OF PERIODICAL CICADAS RELATED TO HISTORICAL BIOGEOGRAPHY

1990 • 78 citations

The Relationship Between Simple Evolutionary Tree Models and Observable Sequence Data

1989 • 78 citations

The evolution of prokaryotic ferredoxins--with a general method correcting for unobserved substitutions in less branched lineages.

1987 • 78 citations

Mitochondrial DNA evolution in primates: Transition rate has been extremely low in the lemur

1990 • 77 citations

Systematic Relationships in the Artiodactyl Tribe Bovini (Family Bovidae), as Determined from Mitochondrial DNA Sequences

1989 • 77 citations

Correcting parsimonious trees for unseen nucleotide substitutions: the effect of dense branching as exemplified by ribonuclease.

1990 • 76 citations

Heterogeneity of tempo and mode of mitochondrial DNA evolution among mammalian orders.

1989 • 74 citations

Sequences of the coding and flanking regions of the large ribosomal subunit RNA gene of mosquito mitochondria

1984 • 71 citations

Rates of molecular evolution and the fraction of nucleotide positions free to vary

1989 • 68 citations

Concerted evolution of sequence repeats inDrosophila mitochondrial DNA

1986 • 68 citations

Albumin Evolution and Its Phylogenetic Implications in the Plethodontid Salamander Genera Plethodon and Ensatina

1979 • 67 citations

EXPERIMENTAL EVIDENCE FOR MITOCHONDRIAL DNA INTROGRESSION BETWEENDROSOPHILASPECIES

1990 • 65 citations

Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species.

1987 • 64 citations

DNA microenvironments and the molecular clock

1989 • 62 citations

Gel electrophoresis and cryptic protein variation.

1982 • 62 citations

Evolution of 13- and 17-Year Periodical Cicadas (Homoptera: Cicadidae: Magicicada)

1988 • 61 citations

A tree reconstruction method that is economical in the number of pairwise comparisons used.

1989 • 60 citations

Anomalous distribution of nuclear and mitochondrial DNA markers in periodical cicadas

1988 • 60 citations

SMALL SAMPLE SIZE DOES DECREASE THE STABILITY OF DENDROGRAMS CALCULATED FROM ALLOZYME‐FREQUENCY DATA

1989 • 58 citations

Colony probing as an alternative to standard sequencing as a means of direct analysis of chromosomal DNA to determine the spectrum of single-base changes in regions of known sequence.

1986 • 55 citations

Intraspecific diversity of nucleotide sequences within the adenine + thymine-rich region of mitochondrial DNA molecules of Drosophila mauritiana, Drosophila melanogaster and Drosophila simulans

1980 • 55 citations

The estimate of total nucleotide substitutions from pairwise differences is biased

1986 • 54 citations

Towards a basis for classification: the incompleteness of distance measures, incompatibility analysis and phenetic classification

1982 • 54 citations

EVOLUTIONARY INFERENCES FROM RESTRICTION MAPS OF MITOCHONDRIAL DNA FROM NINE TAXA OF XENOPUS FROGS

1987 • 53 citations

Insects of Hawaii. Volume 12, Diptera: Cyclorrhapha II, Series Schizophora Section Acalypterae I. Family Drosophilidae.

1965 • 52 citations

Mitochondrial DNA variability in natural populations of Hawaiian Drosophila. I. Methods and levels of variability in D. silvestris and D. heteroneura populations

1986 • 50 citations

Mitochondrial DNA variability in natural populations of Hawaiian Drosophila. II. Genetic and phylogenetic relationships of natural populations of D. silvestris and D. heteroneura

1986 • 48 citations

Evolution of mitochondrial ribosomal RNA in insects as shown by the polymerase chain reaction

1990 • 47 citations

HLA DNA TYPING

1990 • 45 citations

An analysis of the dynamics of mammalian mitochondrial DNA sequence evolution.

1984 • 43 citations

Accuracy of estimating genetic distance between species from short sequences of mitochondrial DNA.

1990 • 38 citations

Chance marsupial relationships

1990 • 37 citations

Nonparametric phylogenetic inference from restriction cleavage sites.

1987 • 34 citations

The gene for the large (16S) ribosomal RNA from the Locusta migratoria mitochondrial genome

1987 • 32 citations

Experimental Evidence for Mitochondrial DNA Introgression between Drosophila Species

1990 • 29 citations

GENETIC PREDICTION OF HEMOPHILIA A

1990 • 28 citations

Different mitochondrial gene orders among insects: exchanged tRNA gene positions in the COII/COIII region between an orthopteran and a dipteran species

1988 • 27 citations

Shifting constraints on tRNA genes during mitochondrial DNA evolution in animals.

1989 • 26 citations

Homoplasy Excess Statistics and Retention Indices: A Reply to Farris

1990 • 23 citations

Problems Arising in Phylogenetic Inference from Restriction-Site Data

1987 • 23 citations

Shifting ditypic site analysis: Heuristics for expanding the phylogenetic range of nucleotide sequences in Sankoff analyses

1989 • 19 citations

Conformational mutation in human mtDNA detected by direct sequencing of enzymatically amplified DNA

1988 • 16 citations

An improved method for estimating sequence divergence of DNA using restriction endonuclease mappings

1981 • 13 citations

Archetypical features in tRNA families

1987 • 12 citations

Nonuniformity of nucleotide substitution rates in molecular evolution: Computer simulation and analysis of 5S ribosomal RNA sequences

1987 • 10 citations

Evolutionary tree reconstruction

1990 • 4 citations

Deleted Work

1955 • 0 citations