Nonuniformity of nucleotide substitution rates in molecular evolution: Computer simulation and analysis of 5S ribosomal RNA sequences

A Mathematical Theory of Communication

1948 • 73,365 citations

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

1980 • 28,067 citations

Evolution of Protein Molecules

1969 • 11,042 citations

The Mathematical Theory of Communication

1948 • 10,147 citations

Construction of Phylogenetic Trees

1967 • 3,637 citations

Punctuated equilibria: an alternative to phyletic gradualism

1972 • 2,996 citations

Comparison of phylogenetic trees

1981 • 2,717 citations

Accuracy of estimated phylogenetic trees from molecular data

1983 • 2,417 citations

A General Theory of Classificatory Sorting Strategies: 1. Hierarchical Systems

1967 • 1,663 citations

The Phylogeny of Prokaryotes

1980 • 1,457 citations

The structure and evolution of the human β-globin gene family

1980 • 1,398 citations

Symbiosis in cell evolution

1981 • 1,386 citations

Estimating Phylogenetic Trees from Distance Matrices

1972 • 1,381 citations

Earth's earliest biosphere : its origin and evolution

1983 • 1,289 citations

Biochemical Evolution

1977 • 1,283 citations

ORIGIN OF EUKARYOTIC CELLS

1971 • 1,213 citations

STRUCTURE OF RIBOSOMAL RNA

1984 • 793 citations

Origin of Eukaryotic Cells.

1971 • 734 citations

Comparative Anatomy of 16-S-like Ribosomal RNA

1985 • 689 citations

Numerical Methods for Inferring Evolutionary Trees

1982 • 650 citations

Mitochondrial origins.

1985 • 606 citations

Phylogeny of the Vibrionaceae, and Recommendation for Two New Genera, Listonella and Shewanella

1985 • 525 citations

A QUANTITATIVE APPROACH TO A PROBLEM IN CLASSIFICATION

1957 • 500 citations

Information theory and the living system

1972 • 500 citations

An examination of the constancy of the rate of molecular evolution

1974 • 483 citations

An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution

1970 • 469 citations

The GenBank genetic sequence databank

1986 • 464 citations

Genes in pieces: were they ever together?

1978 • 440 citations

Has the endosymbiont hypothesis been proven?

1982 • 425 citations

MOLECULAR EVOLUTION OVER THE MUTATIONAL LANDSCAPE

1984 • 415 citations

A Numerical Approach to Phylogenetic Systematics

1970 • 406 citations

On the evolutionary descent of organisms and organelles: a global phylogeny based on a highly conserved structural core in small subunit ribosomal RNA

1984 • 352 citations

Parsimony in Systematics: Biological and Statistical Issues

1983 • 340 citations

Evolutionary change in 5S RNA secondary structure and a phylogenic tree of 54 5S RNA species.

1979 • 330 citations

Accuracy of estimated phylogenetic trees from molecular data

1982 • 326 citations

On the constancy of the evolutionary rate of cistrons

1971 • 318 citations

The Structure and Evolution of the Human /?-Globin Gene Family

1980 • 301 citations

TESTING THE CONSTANT-RATE NEUTRAL ALLELE MODEL WITH PROTEIN SEQUENCE DATA

1983 • 295 citations

Fitting Discrete Probability Distributions to Evolutionary Events

1971 • 277 citations

Structure and function of 5S and 5.8 S RNA.

1976 • 217 citations

On the annular‐to‐wavy flow pattern transition during condensation inside horizontal tubes

1982 • 196 citations

Transfer-RNA: The early adaptor

1981 • 188 citations

Nucleotide sequence of the Dictyostelium discoideum small-subunit ribosomal ribonucleic acid inferred from the gene sequence: evolutionary implications

1983 • 173 citations

Simple method for constructing phylogenetic trees from distance matrices.

1981 • 173 citations

Structure and Functios of 5 S and 5.8 S RNA

1976 • 155 citations

What are mycoplasmas: The relationship of tempo and mode in bacterial evolution

1985 • 152 citations

On the Phenetic Approach to Vertebrate Classification

1977 • 146 citations

Collection of published 5S, 5.8S and 4.5S ribosomal RNA sequences

1986 • 145 citations

Pronounced structural similarities between the small subunit ribosomal RNA genes of wheat mitochondria and Escherichia coli.

1984 • 127 citations

The phylogeny of human globin genes investigated by the maximum parsimony method

1974 • 125 citations

Macromolecular Sequences in Systematic and Evolutionary Biology

1982 • 119 citations

Generalized structures of the 5S ribosomal RNAs

1982 • 117 citations

Conservation of secondary structure in 5 S ribosomal RNA : a uniform model for eukaryotic, eubacterial, archaebacterial and organelle sequences is energetically favourable

1982 • 112 citations

Collection of published 5S and 5.8S ribosomal RNA sequences

1984 • 110 citations

A Biochemical Phylogeny of the Protists

1978 • 105 citations

Secondary structure of eukaryotic cytoplasmic 5S ribosomal RNA.

1981 • 103 citations

The nucieotide sequences of the 5S rRNAs of four mushrooms and their use in studying the pnytogenetk position of bastdiomycetes among the eukaryotes

1983 • 83 citations

A unique secondary folding pattern for 5S RNA corresponds to the lowest energy homologous secondary structure in 17 different prokaryotes

1981 • 79 citations

Wheat embryo mitochondrial 18S ribosomal RNA: evidence for its prokaryotic nature

1977 • 76 citations

Stochastic versus augmented maximum parsimony method for estimating superimposed mutations in the divergent evolution of protein sequences. Methods tested on cytochrome c amino acid sequences

1976 • 76 citations

A second major class of Alu family repeated DNA sequences in a primate genome

1983 • 73 citations

A practical method for calculating evolutionary trees from sequence data

1981 • 73 citations

The architecture of 5S rRNA and its relation to function

1975 • 73 citations

An evaluation of the phylogenetic position of the dinoflagellateCrypthecodinium cohnii based on 5S rRNA characterization

1981 • 69 citations

Primary sequence of wheat mitochondrial 5S ribosomal ribonucleic acid: functional and evolutionary implications

1981 • 68 citations

Phylogeny of protozoa deduced from 5S rRNA sequences

1983 • 68 citations

The nucleotide sequences of the 5 S rRNAs of seven moids and a yeast and their use in studying ascomycete phylogeny

1984 • 64 citations

Evolution of Biochemical Pathways: Evidence From Comparative Biochemistry

1980 • 62 citations

The spatial distribution of fixed mutations within genes coding for proteins

1983 • 60 citations

Evolution of 5sRNA

1975 • 56 citations

Consensus structure and evolution of 5S rRNA

1983 • 52 citations

A strategy for sequence phylogeny research

1982 • 48 citations

Calculation of evolutionary trees from sequence data.

1979 • 43 citations

A Biochemical Phylogeny of the Protists.

1979 • 39 citations

Computer comparison of new and existing criteria for constructing evolutionary trees from sequence data

1982 • 38 citations

Tables of the Negative Binomial Probability Distribution

1965 • 35 citations

Theoretical foundations for quantitative paleogenetics

1980 • 34 citations

The case for a polyphyletic origin of mitochondria: Morphological and molecular comparisons

1984 • 32 citations

Collection of published 5S and 5.8S ribosomal RNA sequences

1983 • 30 citations

5 S and 5.8 S ribosomal RNA sequences and protist phylogenetics

1985 • 28 citations

Phylogenetic origins of the plant mitochondrion based on a comparative analysis of 5S ribosomal RNA sequences

1985 • 27 citations

THE ESTABLISHMENT OF MITOCHONDRIA: PARACOCCUS AND RHODOPSEUDOMONAS

1981 • 27 citations

The Structure and Evolution of Archaebacterial Ribosomal RNA

1985 • 26 citations

Comparative sequence analysis as an approach to evaluating structure, function, and evolution of 5S and 5.8S ribosomal RNAs

1982 • 25 citations

The Phylogenic Structure of the Metabacteria

1982 • 24 citations

The relation of physical properties of alkanes to connectivity indices: a molecular explanation

1982 • 21 citations

Theoretical foundations for quantitative paleogenetics

1981 • 18 citations

An evaluation of mitochondrial tRNA gene evolution and its relation to the genetic code

1982 • 18 citations

Comparative analysis of nucleic acid sequences by their general constraints

1982 • 17 citations

Universal secondary structures of prokaryotic and eukaryotic ribosomal 5S RNA derived from comparative analysis of their sequences.

1981 • 17 citations

Structure of clostridial 5 S ribosomal RNAs and bacterial evolution

1987 • 16 citations

Toward a molecular taxonomy

1971 • 14 citations

Is wheat mitochondrial 5S ribosomal RNA prokaryotic in nature?

1981 • 13 citations

Nuclease S1 analysis of eubacterial 5S rRNA secondary structure

1985 • 11 citations

A general method for biological inference: Illustrated by the estimation of gene nucleotide transition probabilities

1980 • 10 citations

Prokaryotic and Eukaryotic 5 S RNAs: Primary Sequences and Proposed Secondary Structures

1983 • 9 citations

Simulation studies on the evolution of amino acid sequences

1976 • 9 citations

Nucleotide sequences of 5S rRNAs from spongeHalichondria japonicaand tunicateHalocynthia roretziand their phylogenetic positions

1983 • 9 citations

Tables of the Negative Binomial Probability Distribution

1965 • 8 citations

The estimation of differences in protein evolution rates

1980 • 7 citations

Phylogeny of transfer RNA and origins of organelles

1981 • 6 citations

Distribution of mutations in Gram-negative eubacterial 5S rRNAs and significance for sequence analysis

1986 • 2 citations