Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI in Heart Failure

NCT03084679

NAINTERVENTIONAL

University of Campinas, Brazil

90 participants

Started 2017-11-01 · Completed 2020-07

Status: Unknown (as of 12-23-2025)

Conditions

Heart Failure

Interventions

OTHER: Aerobic exercise in treadmill OTHER: Local strengthening exercises OTHER: Stretching exercises

Linked Papers (from SciSciNet-V2)

Total Papers42

Background

8

Result

0

Derived

0

Unknown

34

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The investigators hypothesised that novel MRI metrics derived from myocardium post-gadolinium T1 mapping analysis will improve the current knowledge about the role interstitial fibrosis and cardiomyocyte hypertrophy in the development of left ventricular (LV) remodelling and clinical Heart Failure (HF). The investigators believe that these recently described variables will be associated with prognostically important indices in HF development.

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Background Papers16

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

2,570 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

2,570 citations

Transgenic Gαq overexpression induces cardiac contractile failure in mice

Transgenic Gαq overexpression induces cardiac contractile failure in mice

APJ acts as a dual receptor in cardiac hypertrophy

APJ acts as a dual receptor in cardiac hypertrophy

PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) Trial

PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) Trial

Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging

Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging

Asymmetry of cardiac [123I] meta-iodobenzyl-guanidine scans in patients with ventricular tachycardia and a "clinically normal" heart.

Asymmetry of cardiac [123I] meta-iodobenzyl-guanidine scans in patients with ventricular tachycardia and a "clinically normal" heart.

Myocardial Tissue Remodeling in Adolescent Obesity

Myocardial Tissue Remodeling in Adolescent Obesity

Cardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone

Cardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers34

Spironolactone for Heart Failure with Preserved Ejection Fraction

2,271 citations

Apoptosis in the Failing Human Heart

1,690 citations

Apoptosis in Myocytes in End-Stage Heart Failure

1,446 citations

Left Ventricular Hypertrophy

1,197 citations

Prognostic Significance of Left Ventricular Mass Change During Treatment of Hypertension

Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

Reduction of Cardiovascular Risk by Regression of Electrocardiographic Markers of Left Ventricular Hypertrophy by the Angiotensin-Converting Enzyme Inhibitor Ramipril

Increased Collagen Type I Synthesis in Patients With Heart Failure of Hypertensive Origin

Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.

The Fuzzy Logic of Physiological Cardiac Hypertrophy

Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links.

Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Sudden Cardiac Death Independently of Left Ventricular Ejection Fraction in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction

Cardiac death prediction and impaired cardiac sympathetic innervation assessed by MIBG in patients with failing and nonfailing hearts

I-123 MIBG imaging and heart rate variability analysis to predict the need for an implantable cardioverter defibrillator

Left Ventricular Concentric Remodeling Is Associated With Decreased Global and Regional Systolic Function: The Multi-Ethnic Study of Atherosclerosis

Prognostic Impact of Myocardial Interstitial Fibrosis in Non-Ischemic Heart Failure - Comparison Between Preserved and Reduced Ejection Fraction Heart Failure -

Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat

The cytoskeleton and related proteins in the human failing heart.

Human myocardial histologic characteristics in congestive heart failure.

Expression profiling reveals differences in metabolic gene expression between exercise‐induced cardiac effects and maladaptive cardiac hypertrophy

Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy

Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure

Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats

Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies

Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol

Degree of cardiac fibrosis and hypertrophy at time of implantation predicts myocardial improvement during left ventricular assist device support

Apoptosis of myocytes and proliferation markers as prognostic factors in end-stage dilated cardiomyopathy

The Significance of Cardiac Sympathetic Nervous System Abnormality in the Long-Term Prognosis of Patients with a History of Ventricular Tachyarrhythmia

Detection of apoptosis using in situ markers for DNA strand breaks in the failing human heart. Fact or epiphenomenon?

Myocardial Size and Fibrosis Changes During Left Ventricular Assist Device Support