Genetics of Atherosclerosis in Mexican Americans

NCT00005462

NULLOBSERVATIONAL

National Heart, Lung, and Blood Institute (NHLBI)

NULL participants

Started 1991-09 · Completed 2008-05

Status: Completed (as of 12-23-2025)

Conditions

Cardiovascular DiseasesCoronary DiseaseObesityAtherosclerosisDiabetes Mellitus, Non-insulin Dependent+1 more

Interventions

Linked Papers (from SciSciNet-V2)

Total Papers104

Background

4

Result

0

Derived

0

Unknown

100

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

To identify individual genes that contribute to variation in susceptibility to coronary heart disease (CHD) in Mexican Americans. The program project grant supports the San Antonio Family Heart Study, the first comprehensive genetic epidemiological study of atherosclerosis and its correlates in Mexican Americans.

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Background Papers8

Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees

3,077 citations

Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees

3,077 citations

Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans

Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans

A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.

A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.

Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism

Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers100

The Search for Human Obesity Genes

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

Genetic and Environmental Contributions to Cardiovascular Risk Factors in Mexican Americans

Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages

12 Variance component methods for detecting complex trait loci

Genetic Analysis of the IRS

A variance component approach to dichotomous trait linkage analysis using a threshold model

Robust LOD scores for variance component-based linkage analysis

Genetic Basis of Variation in Carotid Artery Wall Thickness

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Plasma HDL Cholesterol, Triglycerides, and Adiposity

A bias-ed assessment of the use of SNPs in human complex traits

Localization and identification of human quantitative trait loci: King Harvest has surely come

Major gene with sex‐specific effects influences fat mass in Mexican Americans

Leptin concentrations and insulin sensitivity in normoglycemic men

Interactions Between Variants in the β3-Adrenergic Receptor and Peroxisome Proliferator–Activated Receptor-γ2 Genes and Obesity

Genome‐wide linkage analysis of blood pressure in Mexican Americans

A Genome Search Identifies Major Quantitative Trait Loci on Human Chromosomes 3 and 4 That Influence Cholesterol Concentrations in Small LDL Particles

Genetics of Atherosclerosis Risk Factors in Mexican Americans

Searching for genes underlying normal variation in human adiposity

Characterization of a composite gradient gel for the electrophoretic separation of lipoproteins

Quantitative trait locus mapping using human pedigrees.

Serum leptin levels are independently correlated with two measures of HDL

Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees

Genetic Basis of Variation in Carotid Artery Plaque in the San Antonio Family Heart Study

Effect of Diabetes on Lipoprotein Size

Insulin and 2-Hour Glucose Levels Are Inversely Related to Lp(a) Concentrations Controlled for LPA Genotype

A Major Locus Influencing Plasma High-Density Lipoprotein Cholesterol Levels in the San Antonio Family Heart Study

Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples

Statistical Genetic Approaches to Human Adaptability

Ala67Thr polymorphism in the Agouti‐related peptide gene is associated with inherited leanness in humans

Effects of NIDDM on Lipoprotein(a) Concentration and Apolipoprotein(a) Size

Genetic and environmental correlations among hormone levels and measures of body fat accumulation and topography.

Relationship of LDL Size to Insulin Sensitivity in Normoglycemic Men

Is Leptin Concentration Associated with the Insulin Resistance Syndrome in Nondiabetic Men?

Genome-Wide Linkage Analysis of Pulse Pressure in Mexican Americans

A Quantitative Trait Locus on Chromosome 16q Influences Variation in Plasma HDL-C Levels in Mexican Americans

Power of variance component linkage analysis to detect epistasis

Lipid and Lipoprotein Factors Associated With Variation in Lp(a) Density

The emerging pattern of the genetic contribution to human obesity

Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans.

Linkage of Essential Hypertension to the Angiotensinogen Locus in Mexican Americans

Electrophoretic Separation of LDL and HDL Subclasses

Evidence for a Major Gene for Type II Diabetes and Linkage Analyses With Selected Candidate Genes in Mexican-Americans

Is there an excess in maternal transmission of NIDDM?

Genetic analysis of a common oligogenic trait with quantitative correlates: Summary of GAW9 results

Genetic and environmental correlations among skinfold measures.

Diabetes and Hypertension in Mexican American Families: Relation to Cardiovascular Risk

Quantitative genetics of serum sex hormone—binding globulin levels in participants in the San Antonio Family Heart Study

The Effect of Pedigree Complexity on Quantitative Trait Linkage Analysis

Genes Influencing Variation in Serum Osteocalcin Concentrations Are Linked to Markers on Chromosomes 16q and 20q¹

GAW10: Simulated family data for a common oligogenic disease with quantitative risk factors

Evidence for a Major Gene Affecting Postchallenge Insulin Levels in Mexican-Americans

Bivariate Linkage between Acylation‐Stimulating Protein and BMI and High‐Density Lipoproteins

GAW12: Simulated Genome Scan, Sequence, and Family Data for a Common Disease

Characterization of the genetic elements controlling lipoprotein(a) concentrations in Mexican Americans. Evidence for at least three controlling elements linked to LPA, the locus encoding apolipoprotein(a)

Shared and Unique Genetic Effects Among Seven HDL Phenotypes

Exploiting pleiotropy to map genes for oligogenic phenotypes using extended pedigree data

Power of Variance Component Linkage Analysis—II. Discrete Traits

The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study

Effects of diabetes on plasma nitrotyrosine levels

Genotype by smoking interaction for leptin levels in the San Antonio family heart study

Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans

Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans

Genetic Relationship Between Measures of HDL Phenotypes and Insulin Concentrations

Multivariate genetic analysis of apo AI concentration and HDL subfractions: Evidence for major locus pleiotropy

Lp(a) concentrations are related to plasma lipid concentrations

Genetic basis for multimodal relationship between apolipoprotein (a) size and lipoprotein (a) concentration in Mexican-Americans

Association Studies of Vascular Phenotypes

Effects of the ApoE Polymorphism on Plasma Lipoproteins in Mexican Americans

Replication of Linkage to Quantitative Trait Loci: Variation in Location and Magnitude of the Lod Score

Exploring the HDL likelihood surface

Apolipoprotein B (apo B) signal peptide length polymorphisms are associated with apo B, low density lipoprotein cholesterol, and glucose levels in Mexican Americans

Detecting Genotype × Age Interaction

Genetic control of apolipoprotein A-I distribution among HDL subclasses

Triiodothyronine Exerts a Major Pleiotropic Effect on Reverse Cholesterol Transport Phenotypes

A Quantitative Trait Locus on Chromosome 22 for Serum Leptin Levels Adjusted for Serum Testosterone

Asymptotic power of likelihood‐ratio tests for detecting quantitative trait loci using the COGA data

Genetic correlations between lipoprotein phenotypes and indicators of sex hormone levels in Mexican Americans

Linkage Analysis of Quantitative Traits in Randomly Ascertained Pedigrees: Comparison of Penetrance‐Based and Variance Component Analysis

Effects of a Major Gene for Apolipoprotein A-I Concentration Are Thyroid Hormone Dependent in Mexican Americans

Power to Localize the Major Gene for Disease Liability Is Increased After Accounting for the Effects of Related Quantitative Phenotypes

Statistical genetics of normal variation in family data for oligogenic diseases

A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins

Apolipoprotein B and a second major gene locus contribute to phenotypic variation of spontaneous hypercholesterolemia in pigs.

Does Accounting for Mitochondrial Genetic Variation Improve the Fit of Genetic Models?

Lipoprotein Lp(a): effects of allelic variation at the LPA locus.

Genetic Analysis of Quantitative Traits in Highly Ascertained Samples: Total Serum IgE in Families with Asthma

Simulation of a common oligogenic disease with quantitative risk factors. GAW9 problem 2: The answers

Prior segregation analysis and the power to detect linkage

Segregation and linkage analysis of the complex trait Q1

Lp(a) concentrations and phenotypes in children with insulin-dependent diabetes mellitus

Distribution of lod Scores in Oligogenic Linkage Analysis

The anthropological perspective in genetic epidemiology.

The Utility of Bayesian Model Averaging for Detecting Known Oligogenic Effects

The influence of response bias on segregation and linkage analysis

Introduction: Methods for Detecting Genotype × Environment Interaction

PCR Methodology Applied to Genetic Studies of Lipoprotein Metabolism and Atherosclerosis

Using Step‐Wise Linear Regression to Detect “Functional” Sequence Variants: Application to Simulated Data

Introduction: Association and TDT Analyses of Quantitative Traits