Purine and Pyrimidine Metabolism

Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

1980 • 703 citations

Biochemistry of Parasitic Helminths

1982 • 311 citations

Metabolic Compartmentation

1983 • 303 citations

Biochemistry of Parasitic Helminths

1981 • 284 citations

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

1982 • 214 citations

Purine metabolism in Leishmania donovani and Leishmania braziliensis

1978 • 204 citations

Metabolism of Entamoeba histolytica Schaudinn, 1903

1985 • 191 citations

Nucleotide Metabolism: An Introduction

1973 • 169 citations

Conversion of dihydroorotate to orotate in parasitic protozoa

1979 • 155 citations

Incorporation of Radioactive Precursors into DNA and RNA of Plasmodium knowlesi in vitro

1970 • 134 citations

Purine Metabolism in Toxoplasma gondii

1989 • 131 citations

Bifunctional thymidylate synthase‐dihydrofolate reductase in protozoa

1990 • 130 citations

Toxoplasma gondii: Purine synthesis and salvage in mutant host cells and parasites

1982 • 127 citations

Leishmania donovani: Surface membrane acid phosphatase activity of promastigotes

1981 • 124 citations

Purine and Pyrimidine Synthesis by the Avian Malaria Parasite, Plasmodium lophurae*

1968 • 112 citations

Purines and pyrimidines in malarial parasites.

1990 • 98 citations

Purine metabolism in Leishmania donovani amastigotes and promastigotes

1983 • 94 citations

A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi

1979 • 91 citations

A potent nucleoside triphosphate hydrolase from the parasitic protozoan Toxoplasma gondii. Purification, some properties, and activation by thiol compounds.

1983 • 87 citations

Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani

1991 • 87 citations

Purification, characterization, and kinetic analysis of inosine 5′-monophosphate dehydrogenase of Tritrichomonas foetus

1987 • 83 citations

Purine metabolism in Trypanosoma cruzi

1981 • 83 citations

Nucleosidases from Leishmania donovani. Pyrimidine ribonucleosidase, purine ribonucleosidase, and a novel purine 2'-deoxyribonucleosidase.

1979 • 81 citations

Purine metabolism in Trichomonas vaginalis

1982 • 79 citations

Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine.

1979 • 78 citations

Purine salvage networks in Giardia lamblia.

1983 • 76 citations

High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase.

1991 • 72 citations

Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent.

1979 • 72 citations

The Source of Purines and Pyrimidines in Plasmodium Berghei *

1970 • 71 citations

Surface membrane localization of 3′- and 5′-nucleotidase activities in Leishmania donovani promastigotes

1984 • 68 citations

Purine metabolism in the schistosomes: Potential targets for chemotherapy

1983 • 67 citations

The enzymes of pyrimidine biosynthesis in a range of parasitic protozoa and helminths

1981 • 67 citations

A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania

1981 • 67 citations

UMP synthesis in the kinetoplastida

1982 • 66 citations

Purine and pyrimidine metabolizing activities in Trichomonas vaginalis extracts

1983 • 64 citations

Isolation and characterization of adenosine kinase from Leishmania donovani.

1987 • 62 citations

Purine salvage by Tritrichomonas foetus

1983 • 59 citations

Purine and pyrimidine salvage pathways in Leishmania donovani

1982 • 59 citations

Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum

1988 • 58 citations

Purine metabolism in the bloodstream forms of trypanosoma gambiense and Trypanosoma rhodesiense

1982 • 56 citations

Pyrimidine salvage in Giardia lamblia.

1985 • 55 citations

Purine salvage in Schistosoma mansoni schistosomules

1984 • 55 citations

Inosine analogs as chemotherapeutic agents for African trypanosomes: metabolism in trypanosomes and efficacy in tissue culture

1985 • 54 citations

Pyrimidine Synthesis by Intracellular Toxoplasma gondii

1981 • 54 citations

Purine metabolism in the protozoan parasite Eimeria tenella.

1981 • 53 citations

Pyrimidine de novo synthesis during the life cycle of the intraerythrocytic stage of Plasmodium falciparum.

1984 • 53 citations

Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro.

1991 • 53 citations

Pyrimidine de novo Synthesis during the Life Cycle of the Intraerythrocytic Stage of Plasmodium falciparum

1984 • 50 citations

Nucleoside hydrolases from Trypanosoma cruzi.

1984 • 49 citations

Pyrimidine metabolism in Tritrichomonas foetus.

1983 • 48 citations

Nutritional Requirements of Plasmodium falciparum in Culture. III. Further Observations on Essential Nutrients and Antimetabolites¹

1985 • 47 citations

Characterisation of cDNA clones for hypoxanthine–guanine phosphoribosyltransferase from the human malarial parasite,Plasmodium falciparum: comparisons to the mammalian gene and protein

1987 • 47 citations

Adenylosuccinate synthetase and adenylosuccinate lyase from trypanosoma cruzi

1982 • 45 citations

Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes.

1983 • 44 citations

Substrate specificities of 5′-deoxy-5′-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells

1988 • 43 citations

Pyrimidine metabolism in Trichomonas vaginalis

1984 • 43 citations

Human malaria parasite adenosine deaminase. Characterization in host enzyme-deficient erythrocyte culture.

1984 • 43 citations

Leishmania mexicana: Purine-metabolizing enzymes of amastigotes and promastigotes

1985 • 42 citations

Detailed purine salvage metabolism in and outside the free malarial parasite

1975 • 42 citations

Toxoplasma gondii: Specific labeling of nucleic acids of intracellular parasites in Lesch-Nyhan cells

1977 • 42 citations

Purine metabolism in Trypanosoma brucei gambiense

1982 • 41 citations

Metabolic Patterns of Dirofilaria immitis Microfilariae In vitro

1970 • 40 citations

Pyrimidine metabolism in Giardia lamblia trophozoites

1982 • 39 citations

Enzymes of purine salvage in Trypanosoma cruzi

1981 • 38 citations

Molecular Parasitology

2016 • 37 citations

Adenine deaminase of a eukaryotic animal cell, Crithidia fasciculata

1977 • 36 citations

Guanosine 5′-monophosphate reductase from Leishmania donovani

1982 • 33 citations

Uridine phosphorylase from Schistosoma mansoni.

1988 • 33 citations

Purine deoxynucleoside salvage in Giardia lamblia

1989 • 32 citations

A comparative study of the purine- and pyrimidine-metabolising enzymes of a range of trypanosomatids

1986 • 32 citations

Purification and characterization of guanine phosphoribosyltransferase from Giardia lamblia.

1986 • 31 citations

Simplified defined media for cultivating Leishmania donovani promastigotes.

1980 • 31 citations

Schistosoma mansoni: DNA synthesis in males and females from mixed and single-sex infections

1984 • 30 citations

Purification and characterization of the adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase activities from Leishmania donovani

1989 • 30 citations

Adenosine analog metabolism in Giardialamblia

1986 • 29 citations

Brugia pahangi: Uptake and incorporation of nucleic acid precursors by microfilariae and macrofilariae in vitro

1981 • 28 citations

Trypanosoma cruzi adenine nucleoside phosphorylase

1987 • 27 citations

Characterization of adenine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum

1989 • 27 citations

Inhibition of growth and purine-metabolizing enzymes of trypanosomid flagellates by N6-methyladenine

1980 • 24 citations

Glutamine-dependent carbamoyl-phosphate synthetase and control of pyrimidine biosynthesis in the parasitic helminth Schistosoma mansoni

1979 • 24 citations

A purine nucleoside hydrolase from Trypanosoma gambiense, purification and properties.

1975 • 23 citations

Pyrimidine salvage pathways in adult Schistosoma mansoni

1990 • 23 citations

Purine Salvage in Entamoeba histolytica

1985 • 22 citations

Comparative aspects of purine metabolism in some African trypanosomes

1983 • 21 citations

Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy.

1986 • 21 citations

Incorporation of Radioactive Pyrimidine Nucleosides into DNA and RNA of Eimeria tenella (Coccidia) Cultured In Vitro*

1973 • 21 citations

Purification and characterization of the 3′-nucleotidase/nuclease from promastigotes of Leishmania donovani

1991 • 21 citations

Biosynthesis de novo of purines and pyrimidines in Mesocestoides (Cestoda). II.

1970 • 20 citations

Enzymes of pyrimidine biosynthesis in Trypanosoma cruzi

1980 • 19 citations

Action of tubercidin and other adenosine analogs onSchistosoma mansoni schistosomules

1985 • 19 citations

The deoxyribonucleoside phosphotransferase of Trichomonas vaginalis. A potential target for anti-trichomonial chemotherapy.

1984 • 19 citations

Purine nucleotide metabolism in promastigotes of Leishmania tropica: inhibitory effect on allopurinol and analogues of purine nucleosides.

1978 • 18 citations

Folate metabolism in filariae: enzymes associated with 5,10-methylenetetrahydrofolate.

1980 • 18 citations

Purine metabolism by the avian malarial parasite Plasmodium lophurae

1981 • 17 citations

The effect of growth inhibitors on postembryonic development in the free-living nematode, Pangrellus silusiae

1970 • 17 citations

Incorporation of Purines and Pyrimidines into Axenically Grown Entamoeba histolytica

1976 • 16 citations

Enzymes of uridine 5′-monophosphate biosynthesis in Schistosoma mansoni

1984 • 15 citations

Purine metabolism in the intact sporozoites and merozoites of Eimeria tenella

1985 • 15 citations

Folate Metabolism in Filariae: Enzymes Associated with 5,10-Methylenetetrahydrofolate

1980 • 15 citations

Stage-specific differences of a perhaps signal-transferring system in Leishmania donovani.

1980 • 15 citations

Purification, characterization, substrate and inhibitor specificity of adenosine kinase from several Eimeria species

1982 • 15 citations

Characterization of Nucleoside Transport in Hymenolepidid Cestodes

1975 • 14 citations

Pyrimidine nucleotide biosynthesis in Clonorchis sinensis and Paragonimus ohirai

1978 • 13 citations

The Partial Purification and Characterization of Adenosine Kinase from Entamoeba histolytica *

1983 • 13 citations

Antigiardial activity of guanine arabinoside mechanism studies

1987 • 13 citations

Entamoeba histolytica: Nucleic acid precursors affecting axenic growth

1980 • 12 citations

Pyrimidine Metabolism in Tritrichomonas foetus

1983 • 12 citations

Toxoplasma gondii viewed from a virological perspective.

1988 • 12 citations

Biosynthesis de novo of Purines and Pyrimidines in Mesocestoides (Cestoda). II

1970 • 12 citations

Aspartate transcarbamylase in some parasitic platyhelminths

1974 • 11 citations

Xanthine Phosphoribosyltransferase inLeishmania:Divalent Cation Activation1

1982 • 11 citations

Induced Division Synchrony in Entamoeba Histolytica

1983 • 10 citations

Purine nucleotide synthesis in Entamoeba histolytica: a preliminary study.

1980 • 10 citations

INCORPORATION OF TRITIATED THYMIDINE IN THE CELLS OF CAENORHABDITIS BRIGGSAE (NEMATODA) REARED IN AXENIC CULTURE

1964 • 8 citations

Thymidine kinase activity and thymidine salvage in adult Brugia pahangi and Dirofilaria immitis

1982 • 7 citations

Characteristics of Cytidine Aminohydrolase Activity in Trypanosoma cruzi and Crithidia fasciculata1

1984 • 7 citations

Leishmania mexicana: Conversion of dihydroorotate to orotate in amastigotes and promastigotes

1982 • 7 citations

The metabolism of pyrimidine and purine in Schistosoma japonicum.

1984 • 6 citations

Purine phosphoribosyltransferases of Leishmania mexicana mexicana and other flagellate protozoa

1985 • 6 citations

Uptake of selected pyrimidines by axenically grown Entamoeba histolytica.

1978 • 5 citations

Thymidylate Synthetase as a Chemotherapeutic Target in the Treatment of Avian Coccidiosis*

1980 • 5 citations

Independent characterization of thymidine transport and subsequent metabolism in Hymenolepis diminuta—II. Purification and preliminary analysis of thymidine kinase

1991 • 3 citations

[Utilization by Eimeria tenella sporozoites (Coccidiida, Sporozoa) of (14C)aspartic and (14C)orotic acids for the biosynthesis of pyrimidine nucleotides].

1982 • 1 citations