Bifunctional thymidylate synthase‐dihydrofolate reductase in protozoa

Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi

1988 • 784 citations

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

1988 • 634 citations

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

1988 • 507 citations

Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design

1987 • 329 citations

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

1987 • 261 citations

Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization

1984 • 260 citations

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

1983 • 239 citations

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major.

1986 • 165 citations

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica

1985 • 157 citations

Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257

1989 • 149 citations

Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene.

1989 • 147 citations

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

1984 • 145 citations

Isolation and expression of the Pneumocystis carinii thymidylate synthase gene.

1989 • 137 citations

Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.

1980 • 130 citations

Stable Amplified DNA in Drug-Resistant Leishmania Exists as Extrachromosomal Circles

1986 • 124 citations

Folate metabolism in malaria.

1977 • 120 citations

Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum

1989 • 115 citations

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

1986 • 92 citations

Extrachromosomal elements in the lower eukaryote Leishmania.

1988 • 68 citations

Protein expression in Escherichia coli minicells containing recombinant plasmids specifying trimethoprim-resistant dihydrofolate reductases

1980 • 60 citations

Sequence of a cDNA for mouse thymidylate synthase reveals striking similarity with the prokaryotic enzyme.

1986 • 58 citations

Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines

1988 • 57 citations

Transcriptional Mapping of the Amplified Region Encoding the Dihydrofolate Reductase-Thymidylate Synthase of Leishmania major Reveals a High Density of Transcripts, Including Overlapping and Antisense RNAs

1989 • 49 citations

Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major

1988 • 46 citations

Nucleotide sequence of the thymidylate synthase B and dihydrofolate reductase genes contained in one Bacillus subtilis operon

1988 • 44 citations

Cloning, Sequencing, and Expression of theLactobacillus caseiThymidylate Synthase Gene

1988 • 43 citations

Nucleotide sequence reveals overlap between T4 phage genes encoding dihydrofolate reductase and thymidylate synthase.

1984 • 43 citations

Gene Amplification In Leishmania

1991 • 42 citations

Intracellular organization of DNA precursor biosynthetic enzymes

1988 • 40 citations

Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth

1987 • 39 citations

The Carboxypeptidase-dependent Inactivation of Thymidylate Synthetase

1974 • 39 citations

Point mutations and pyrimethamine resistance in Plasmodium falciparum

1989 • 36 citations

DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.

1985 • 35 citations

Presence and properties of thymidylate synthase in trypanosomatids

1977 • 33 citations

Structure, genomic organization and transcription of the bifunctional dihydrofolate reductase-thymidylate synthase gene from Crithidia fasciculata

1989 • 30 citations

Sequence and S1 nuclease mapping of the 5′ region of the dihydrofolate reductase—thymidylate synthase gene ofLeishmania major

1987 • 30 citations

Treatment of Cutaneous Leishmaniasis with Trimethoprim-Sulfamethoxazole Combination

1973 • 30 citations

Dihydrofolate Reductase from Eimeria tenella: Rationalization of Chemotherapeutic Efficacy of Pyrimethamine

1975 • 27 citations

Thymidylate synthetase in mouse erythrocytes infected with Plasmodium berghei.

1973 • 26 citations

Treatment of American Cutaneous Leishmaniasis with Cycloguanil Pamoate

1968 • 25 citations

Electron microscopy of amplified DNA forms in antifolate-resistant Leishmania.

1987 • 23 citations

The gel-filtration behaviour of dihydrofolate reductases from culture forms of trypanosomatids

1969 • 22 citations

Purification of the bifunctional thymidylate synthase-dihydrofolate reductase complex from the human malaria parasite Plasmodium falciparum.

1987 • 18 citations

T4 phage-coded dihydrofolate reductase. Subunit composition and cloning of its structural gene.

1981 • 18 citations

Limited proteolysis of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica.

1985 • 18 citations

Coregulation of dihydrofolate reductase and thymidylate synthase B in Bacillus subtilis

1985 • 12 citations

A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.

1987 • 7 citations