Adult T Cell Leukaemia

Antibodies to adult t‐cell leukemia‐virus‐associated antigen (atla) in sera from patients with atl and controls in japan: A nation‐wide sero‐epidemiologic study

1982 • 607 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Vitamin A and Retinoids in Health and Disease

1984 • 560 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer.

1989 • 467 citations

Clinical Course of Retrovirus-Associated Adult T-Cell Lymphoma in the United States

1983 • 431 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

Modelling the risk of adult T‐cell leukemia/lymphoma in persons infected with human T‐lymphotropic virus type I

1989 • 391 citations

Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection

1995 • 373 citations

Treatment of Adult T-Cell Leukemia–Lymphoma with a Combination of Interferon Alfa and Zidovudine

1995 • 373 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy

1995 • 308 citations

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

1991 • 287 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa

1995 • 271 citations

Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations

1992 • 259 citations

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac [see comments]

1995 • 253 citations

Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.

1995 • 240 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

Human T-lymphotropic virus type I in Japan

1994 • 220 citations

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

1993 • 207 citations

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.

1990 • 194 citations

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia

1995 • 175 citations

Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia.

1984 • 162 citations

Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

1991 • 153 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Monoclonal integration of HTLV‐I proviral DNA in patients with strongyloidiasis

1987 • 137 citations

Major prognostic factors of adult patients with advanced T-cell lymphoma/leukemia.

1988 • 136 citations

Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression

1986 • 129 citations

High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis

1990 • 129 citations

Significance of soluble interleukin-2 receptor levels for evaluation of the progression of adult T-cell leukemia

1994 • 123 citations

Establishment of human cytotoxic T cell lines specific for human adult T cell leukemia virus-bearing cells.

1983 • 121 citations

Expression of P-glycoprotein in adult T-cell leukemia cells

1990 • 119 citations

Integration Patterns of HTLV-I Provirus in Relation to the Clinical Course of ATL: Frequent Clonal Change at Crisis From Indolent Disease

1997 • 118 citations

Polymerase chain reaction analysis of defective human T-cell leukemia virus type I proviral genomes in leukemic cells of patients with adult T-cell leukemia

1991 • 114 citations

Adult T-cell Leukemia.

1995 • 110 citations

Clonal Expansion of Infected Cells: A Way of Life for HTLV-I

1996 • 109 citations

Phenotypic diversity and prognosis of adult T-cell leukemia

1992 • 103 citations

The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface

1996 • 103 citations

Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP)

1992 • 102 citations

A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction

1994 • 97 citations

Central nervous system involvement in adult T-cell leukemia/lymphoma

1990 • 96 citations

Human T-cell leukemia-lymphoma virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy

1991 • 96 citations

Mini Review: Adult T-Cell Leukemia in Japan

1996 • 95 citations

An Intensive Chemotherapy of Adult T-Cell Leukemia/Lymphoma: CHOP Followed by Etoposide, Vindesine, Ranimustine, and Mitoxantrone with Granulocyte Colony-Stimulating Factor Support

1996 • 94 citations

Time-schedule dependency of the inhibiting activity of various anticancer drugs in the clonogenic assay

1985 • 93 citations

Transcriptional Repression of p53 by Human T-cell Leukemia Virus Type I Tax Protein

1995 • 89 citations

The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes

1996 • 88 citations

The Epidemiology of Human T‐lymphotropic Virus Types I and II

1993 • 85 citations

Infusional cyclophosphamide, doxorubicin, and etoposide in human immunodeficiency virus- and human T-cell leukemia virus type I-related non-Hodgkin's lymphoma: a highly active regimen

1993 • 81 citations

Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.

1983 • 80 citations

Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway.

1996 • 78 citations

Treatment of adult T-cell leukaemia–lymphoma with irinotecan hydrochloride (CPT-11)

1994 • 76 citations

Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM.

1996 • 75 citations

Adult T-Cell Leukemia/Lymphoma in Jamaica: 1986-1995

1996 • 74 citations

Treatment with a Combination of Zidovudine and α-Interferon in Naive and Pretreated Adult T-Cell Leukemia/Lymphoma Patients

1996 • 73 citations

T‐cell malignancies in Brazil. Clinico‐pathological and molecular studies of HTLV‐I‐positive and ‐negative cases

1995 • 69 citations

Recombinant interferon beta and gamma in the treatment of adult T-cell leukemia

1987 • 68 citations

Successful treatment of HTLV‐1‐associated acute adult T‐cell leukaemia lymphoma by allogeneic bone marrow transplantation

1996 • 64 citations

Deoxycoformycin in the treatment of mature T-cell leukaemias

1991 • 63 citations

Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells

1996 • 62 citations

Possible Roles of an Adult T-Cell Leukemia (ATL)-Derived Factor/Thioredoxin in the Drug Resistance of ATL to Adriamycin

1997 • 59 citations

Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype.

1992 • 54 citations

Treatment of adult T-cell leukemia/lymphoma with MST-16, a new oral antitumor drug and a derivative of bis(2,6-dioxopiperazine)

1993 • 50 citations

Infection of donor lymphocytes with human T lymphotrophic virus type 1 (HTLV‐I) following allogeneic bone marrow transplantation for HTLV‐I positive adult T‐cell leukaemia

1994 • 49 citations

Defective human T-cell leukemia virus in adult T-cell leukemia patients.

1984 • 44 citations

Antiviral effect of zidovudine in the experimental model of adult T cell leukemia in rabbits

1990 • 41 citations

Phase I Study of YK-176 (2′-Deoxycoformycin) in Patients with Adult T-cell Leukemia-lymphoma

1992 • 39 citations

HTLV-1 T cell lymphoma in a cyclosporine-treated renal transplant patient.

1989 • 38 citations

Deoxycoformycin in the Treatment of Leukemias and Lymphomasa

1985 • 36 citations

Adult T Cell Leukemia/Lymphoma

1991 • 33 citations

Enhanced MDR1 Gene Expression in Human T-Cell Leukemia Virus-I–Infected Patients Offers New Prospects for Therapy

1998 • 32 citations

Hematopoietic progenitor cells from patients with adult T-cell leukemia- lymphoma are not infected with human T-cell leukemia virus type 1

1993 • 31 citations

Treatment of adult T cell leukemia with mega-dose cyclophosphamide and total body irradiation followed by allogeneic bone marrow transplantation.

1987 • 30 citations

Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors.

1995 • 30 citations

Quantification of HTLV-1 proviral copy number in peripheral blood of symptomless carriers from the French West Indies.

1992 • 28 citations

Combination Chemotherapy (RCM Protocol: Response-Oriented Cyclic Multidrug Protocol) For the Acute or Lymphoma Type Adult T-cell Leukemia

1995 • 28 citations

Adult T-Cell Leukemia/Lymphoma in London: Clinical Experience of 21 Cases

1998 • 28 citations

Adult T-Cell Leukemia/Lymphoma in a Renal Transplant Recipient: An Opportunistic Occurrence

1994 • 26 citations

Viral Transformation Of Human T Lymphocytes

1994 • 26 citations

Adult T-cell leukemia with an unusual phenotype, Leu-2a positive and Leu-3a negative

1985 • 26 citations

Chromosome and gene rearrangements in immortalized human lymphocytes infected with human T-lymphotropic virus type I.

1990 • 25 citations

Accelerated declining tendency of human T-cell leukemia virus type I carrier rates among younger blood donors in Kumamoto, Japan.

1992 • 24 citations

Clinical significance of beta 2-microglobulin in serum of adult T cell leukemia.

1995 • 22 citations

A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia–lymphoma

1991 • 22 citations

Howard Temin memorial lectureship, Molecular biology of HTLV-1: deregulation of host cell gene expression and cell cycle

1997 • 21 citations

Multiple targets of HTLV-1 for dysregulation of host cells

1996 • 18 citations

Serum deoxythymidine kinase in adult T-cell leukemia-lymphoma and its related disorders

1991 • 17 citations

A new classification of clinical stages of adult T-cell leukemia based on prognosis of the disease.

1994 • 17 citations

Successful treatment of a patient with adult T-cell leukemia by daily oral administration of low-dose etoposide. Decrease in the amount of HTLV-I proviral DNA revealed by the polymerase chain reaction method

1993 • 16 citations

Host-HTLV Type I Interaction at the Molecular Level

1994 • 16 citations

Satisfactory remission achieved by PUVA therapy in a case of crisis-type adult T-cell leukaemia/lymphoma with generalized cutaneous leukaemic cell infiltration

1995 • 16 citations

Synergistic cytotoxicity of AZT plus alpha and gamma interferon in chronic myeloid leukemia cell line K562*

1993 • 14 citations

New therapeutic effects of retinoid for adult T-cell leukemia [letter]

1996 • 14 citations

Adult T-Cell Leukemia (ATL) with an Unusual Immunophenotype and a High Cellular Proliferation Rate

1996 • 14 citations

[Clinical study on the effect of natural alpha-interferon (HLBI) in the treatment of adult T-cell leukemia].

1988 • 13 citations

[Adult T-cell leukemia and non-malignant adenopathies associated with HTLV I virus. Apropos of 17 patients born in the Caribbean region and Africa].

1990 • 12 citations

Total body irradiation as a primary treatment for adult T-cell leukemia.

1983 • 10 citations

Azidothymidine and interferon-alpha in vitro effects on hematopoiesis: protective in vitro activity of IL-1 and GM-CSF.

1995 • 9 citations

Unintegrated HTLV-I proviral DNA in cell lines and uncultured peripheral blood mononuclear cells from tropical spastic paraparesis (TSP/HAM) and adult T-cell leukemia (ATL) patients.

1994 • 2 citations

Deleted Work

1955 • 0 citations

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