The Pathogenesis of Immunologically Mediated Diabetes

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

1987 • 823 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

Factors Associated with Early Remission of Type I Diabetes in Children Treated with Cyclosporine

1988 • 330 citations

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

1986 • 321 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study.

1985 • 237 citations

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

1982 • 221 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

1982 • 193 citations

CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATS

1983 • 183 citations

Stimulation of lymphokine release from T lymphoblasts. Requirement for mRNA synthesis and inhibition by cyclosporin A.

1984 • 176 citations

The BB rat

1987 • 174 citations

UCLA symposia on molecular and cellular biology

1982 • 173 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells.

1986 • 156 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Preventive effects of Cyclosporin on diabetes in NOD mice

1986 • 155 citations

Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes

1981 • 147 citations

Experimental Allergic Encephalomyelitis: Enhancement of Cell-Mediated Transfer by Concanavalin A

1977 • 139 citations

Inhibition of T‐Cell Activity by Cyclosporin A

1982 • 133 citations

Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice

1986 • 123 citations

Autoimmune Diabetes in NOD Mouse Is L3T4 T-Lymphocyte Dependent

1987 • 115 citations

Combined Treatment With Nicotinamide and Desferrioxamine Prevents Islet Allograft Destruction in NOD Mice

1986 • 110 citations

The immunology of diabetes mellitus

1991 • 105 citations

?-Cell damage in diabetic insulitis: are we approaching a solution?

1984 • 105 citations

Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice

1987 • 96 citations

The Onset and Progression of Pancreatic Insulitis in the Overt, Spontaneously Diabetic, Young Adult BB Rat Studied by Pancreatic Biopsy

1984 • 95 citations

A molecular basis for genetic susceptibility to insulin-dependent diabetes mellitus

1988 • 86 citations

Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice

1982 • 74 citations

Involvement of O₂radicals in ‘autoimmune’ diabetes

1989 • 74 citations

Administration of silica prevents diabetes in BB-rats

1985 • 70 citations

Spontaneous Diabetes Mellitus in the BB/W Rat: Effects of Glucocorticoids, Cyclosporin-A, and Antiserum to Rat Lymphocytes

1983 • 68 citations

Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted.

1985 • 59 citations

Islet Allografts Are Destroyed by Disease Occurrence in the Spontaneously Diabetic BB Rat

1986 • 56 citations

Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent

1987 • 49 citations

Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice

1986 • 44 citations

EFFECT OF CYCLOSPORINE ON IMMUNOLOGICALLY MEDIATED DIABETES IN NONOBESE DIABETIC MICE1

1988 • 40 citations

Transplantation of cultured pancreatic islets to BB rats.

1986 • 40 citations

The onset and progression of pancreatic insulitis in the overt, spontaneously diabetic, young adult BB rat studied by pancreatic biopsy

1984 • 35 citations

The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration.

1985 • 33 citations

Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes

1983 • 27 citations

Islet allografts are destroyed by disease occurrence in the spontaneously diabetic BB rat

1986 • 26 citations

Elevated antibody-dependent cell-mediated cytotoxicity and its inhibition by nicotinamide in the diabetic NOD mouse

1986 • 22 citations

Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.

1985 • 19 citations

BLOCKING OF DELIVERY OF THE ANTIGEN-MEDIATED SIGNAL TO THE NUCLEUS OF T CELLS BY CYCLOSPORINS

1987 • 19 citations

Prevention of diabetes in BB rats by intermittent administration of cyclosporine.

1987 • 17 citations

In vivo administration of interleudin-l inhibits glucose-stimulated insulin release

1989 • 11 citations

A Novel Form of T-T Collaboration Requiring the Active Participation of the Antigen-Presenting Cell

1988 • 5 citations

Cyclosporine A and the regulation of autoimmune disease

1988 • 5 citations

Deleted Work

1955 • 0 citations