The BB rat

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

CHRONIC THYROIDITIS AND AUTOIMMUNIZATION

1957 • 535 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Lines of T Lymphocytes Induce or Vaccinate Against Autoimmune Arthritis

1983 • 418 citations

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1977 • 409 citations

The spontaneously diabetic Wistar rat (the ?BB? rat)

1978 • 267 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes

1979 • 212 citations

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

1985 • 208 citations

The Effect of Iodide Ingestion on the Development of Spontaneous Lymphocytic Thyroiditis in the Diabetes-Prone BB/W Rat*

1986 • 207 citations

Dietary protein: a trigger of insulin-dependent diabetes in the BB rat?

1984 • 205 citations

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

1982 • 193 citations

CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATS

1983 • 183 citations

Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.

1986 • 179 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

1981 • 155 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

The BB Diabetic Rat: Profound T-Cell Lymphocytopenia

1981 • 153 citations

Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.

1983 • 152 citations

The immune system: a web of V-domains.

1974 • 138 citations

Spontaneous Activity of Primary Afferent Neurons in Diabetic BB/Wistar Rats: A Possible Mechanism of Chronic Diabetic Neuropathic Pain

1985 • 137 citations

Lymphocytic Thyroiditis and Diabetes in the BB/W Rat: A New Model of Autoimmune Endocrinopathy

1981 • 119 citations

Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

1985 • 111 citations

LYMPHOPENIA AND ABNORMAL LYMPHOCYTE SUBSETS IN THE “BB” RAT: RELATIONSHIP TO THE DIABETIC SYNDROME

1982 • 98 citations

The Onset and Progression of Pancreatic Insulitis in the Overt, Spontaneously Diabetic, Young Adult BB Rat Studied by Pancreatic Biopsy

1984 • 95 citations

Diabetic Autonomic Neuropathy in BB Rat: Ultrastructural and Morphometric Changes in Parasympathetic Nerves

1986 • 88 citations

Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.

1985 • 87 citations

Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

1984 • 84 citations

Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.

1986 • 83 citations

In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

1985 • 79 citations

Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.

1984 • 78 citations

The discovery and development of the BB rat colony: An animal model of spontaneous diabetes mellitus

1983 • 77 citations

Virus-Induced Diabetes Mellitus: Glucose Abnormalities Produced in Mice by the Six Members of the Coxsackie B Virus Group

1982 • 77 citations

Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells.

1986 • 77 citations

Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light-microscopic and ultrastructural observations of pancreatic islets of Langerhans.

1982 • 76 citations

Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

1984 • 76 citations

Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic.

1986 • 74 citations

Spontaneous Diabetes in the Gnotobiotic BB/W Rat

1979 • 74 citations

The BB-rat-an authentic model of human diabetic retinopathy

1985 • 73 citations

Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.

1984 • 73 citations

Transfusions of Whole Blood Prevent Spontaneous Diabetes Mellitus in the BB/W Rat

1983 • 71 citations

Autoantibodies in the BB/W Rat

1982 • 70 citations

Administration of silica prevents diabetes in BB-rats

1985 • 70 citations

Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat

1984 • 69 citations

Diabetic autonomic neuropathy. The distribution of structural changes in sympathetic nerves of the BB rat.

1985 • 68 citations

Spontaneous Diabetes Mellitus in the BB/W Rat: Effects of Glucocorticoids, Cyclosporin-A, and Antiserum to Rat Lymphocytes

1983 • 68 citations

Gastric Parietal Cell and Other Autoantibodies in the BB Rat

1982 • 64 citations

Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted.

1985 • 59 citations

Diet Can Prevent Diabetes in the BB Rat

1985 • 59 citations

Islet Allografts Are Destroyed by Disease Occurrence in the Spontaneously Diabetic BB Rat

1986 • 56 citations

Spontaneous diabetes mellitus syndrome in the rat. IV. Immunogenetic interactions of MHC and non-MHC components of the syndrome

1983 • 52 citations

The Integrity of the Body

1962 • 50 citations

Spontaneous diabetes in BB rats: Evidence for a T cell dependent immune response defect

1982 • 49 citations

Analytical and functional studies on the T cells of untreated and immunologically tolerant diabetes-prone BB rats.

1983 • 44 citations

Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy

1981 • 43 citations

Total Lymphoid Irradiation Prevents Diabetes Mellitus in the Bio-Breeding/Worcester (BB/W) Rat

1984 • 43 citations

Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

1986 • 42 citations

Insulin-Dependent Diabetes Mellitus Is Associated With Genes That Map to the Right of the Class I RT1.A Locus of the Major Histocompatibility Complex of the Rat

1986 • 42 citations

Passive transfer of diabetes from BB/W to Wistar-Furth rats.

1985 • 42 citations

Virus-induced diabetes mellitus. Glucose abnormalities produced in mice by the six members of the Coxsackie B virus group

1982 • 42 citations

Glomerular manifestations of diabetes in the BB rat

1983 • 41 citations

Spontaneous Autoimmune Diabetes mellitus in the BioBreeding/Worcester Rat

1984 • 39 citations

Genetic analysis of the BB/W diabetic rat

1983 • 39 citations

Recombinant interleukin 2 enhances spontaneous insulin‐dependent diabetes in BB rats

1986 • 38 citations

CAN THE BB‐RAT HELP TO UNRAVEL DIABETIC NEUROPATHY?

1985 • 38 citations

Autoantibodies in the BB/W rat

1982 • 34 citations

Time Course of the Lymphopenia in BB Rats: Relation to the Onset of Diabetes

1985 • 34 citations

Gonadal Dysfunction in the Spontaneously Diabetic BB Rat: Alterations of Testes Morphology, Serum Testosterone and LH

1985 • 33 citations

Muscle protein catabolism in diabetes: 3-Methylhistidine excretion in the spontaneously diabetic “BB” rat

1980 • 32 citations

Central-peripheral distal axonopathy in the spontaneously diabetic BB-rat: ultrastructural and morphometric findings

1985 • 31 citations

Isolation of T-Lymphocyte Lines with Specificity for Islet Cell Antigens from Spontaneously Diabetic (Insulin-dependent) Rats

1984 • 30 citations

The BB Wistar rat: An experimental model for the study of diabetic retinopathy

1983 • 30 citations

Spontaneous diabetes in the gnotobiotic BB/W rat

1979 • 29 citations

Diet can prevent diabetes in the BB rat

1985 • 28 citations

Abnormal cardiac biochemistry in spontaneously diabetic Bio-Breeding/Worcester rat

1985 • 28 citations

Hormonal and environmental factors in the pathogenesis of BB rat diabetes

1983 • 27 citations

Gastric parietal cell and other autoantibodies in the BB rat

1982 • 27 citations

The effects of maternal diabetes on fetal maturation and neonatal health

1983 • 27 citations

Lymphocyte abnormalities in the BB rat

1983 • 27 citations

Islet allografts are destroyed by disease occurrence in the spontaneously diabetic BB rat

1986 • 26 citations

Pathological lesions in the spontaneously diabetic BB Wistar rat: A comprehensive autopsy study

1983 • 26 citations

Transplantation of Islets and Bone Marrow Cells to Animals with Immune Insulitis

1982 • 26 citations

Lymphoid Cells of BB/W Diabetic Rats Are Cytotoxic to Islet Beta Cells In Vitro

1985 • 25 citations

Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat

1984 • 25 citations

Influence of islet and bone marrow transplantation on the diabetes and immunodeficiency of BB rats

1983 • 24 citations

Increased incidence of Ia antigen-bearing T lymphocytes in the spontaneously diabetic BB rat.

1985 • 23 citations

Textbook of immunology: An introduction to immunochemistry and immunobiology

1983 • 22 citations

Spontaneous diabetes mellitus syndrome in the rat. III. Pancreatic alterations in aglycosuric and untreated diabetic BB Wistar-derived rats

1983 • 22 citations

PASSIVE TRANSFER OF INSULITIS FROM THE “BBrdquo; RAT TO THE NUDE MOUSE

1981 • 22 citations

Association of Spontaneous Thyroiditis with the Major Histocompatibility Complex of the Rat*

1985 • 21 citations

Hepatic carbohydrate metabolism in the spontaneously diabetic Bio-Breeding Worcester rat

1981 • 20 citations

Renin Secretion by the Spontaneously Diabetic Rat

1986 • 20 citations

T cell hybrids with specificity for islet cell antigens.

1986 • 19 citations

Insulin and glucagon secretion in BB Wistar rats with impaired glucose tolerance

1983 • 19 citations

Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.

1985 • 19 citations

The spontaneously diabetic Wistar rat (the "BB" rat): the significance of transient glycosuria.

1978 • 19 citations

B cell lymphoproliferation in spontaneously diabetic BB Wistar rats

1982 • 17 citations

Insulin-dependent diabetes mellitus is associated with genes that map to the right of the class I RT1.A locus of the major histocompatibility complex of the rat

1986 • 17 citations

Cyclosporin prophylaxis induces long-term prevention of diabetes, and inhibits lymphocytic infiltration in multiple target tissues in the high-risk BB rat.

1986 • 17 citations

Mitogen Responsiveness of Lymphocytes From the BB/W Rat

1986 • 16 citations

The effect of inbreeding on the BB/W diabetic rat

1983 • 16 citations

Isolation and characterization of a cDNA clone for the MHC class II chain RTI.D? u of the diabetic BB rat

1985 • 16 citations

111Indium-labelled lymphocytes do not image or label the pancreas of the BB/W rat

1985 • 15 citations

Altered regulation of cardiac glycogen metabolism in spontaneously diabetic rats

1983 • 15 citations

Time course of the lymphopenia in BB rats. Relation to the onset of diabetes

1985 • 15 citations

Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats.

1985 • 14 citations

Passive transfer of insulitis and lymphopenia in the BB rat

1983 • 13 citations

Diabetic autonomic neuropathy in the BB rat. Ultrastructural and morphometric changes in sympathetic nerves

1985 • 12 citations

Isolation of T-lymphocyte lines with specificity for islet cell antigens from spontaneously diabetic (insulin-dependent) rats

1984 • 12 citations

Lymphoid cells of BB/W diabetic rats are cytotoxic to islet beta cells in vitro

1985 • 12 citations

"Activated" T-lymphocyte levels in the spontaneously diabetic BB rat syndrome.

1985 • 11 citations

Specific Class II Histocompatibility Gene Polymorphism in BB Rats

1984 • 10 citations

Time Course of Serum Glucoregulatory Variables and Lipids following Neonatal Thymectomy of Diabetes-Prone and Control BB Wistar Rats Fed a Defined Diet

1984 • 10 citations

Recommended nomenclature for the spontaneously diabetic syndrome of the BB rat

1983 • 10 citations

Mitogen responsiveness of lymphocytes from the BB/W rat

1986 • 9 citations

Impaired Hepatic Metabolism of Somatostatin-14 and Somatostatin-28 in Spontaneously Diabetic BB Rats*

1984 • 9 citations

Renin secretion by the spontaneously diabetic rat

1986 • 8 citations

Failure to transfer insulitis to athymic recipients using BB/W rat lymphoid tissue transplants

1983 • 6 citations

Specific class II histocompatibility gene polymorphism in BB rats

1984 • 5 citations

Sensitivity of BB rat beta cells as determined by dose-responses to the cytotoxic effects of streptozotocin and alloxan.

1986 • 5 citations

Irradiated lymphocytes do not adoptively transfer diabetes or prevent spontaneous disease in the rat

1986 • 4 citations

Lymphoproliferative lesions in BB Wistar rats

1983 • 4 citations

Cortisone Fails to Affect Levels of Islet Cell Surface Antibodies and Incidence of Diabetes in the BB Rat*

1985 • 2 citations

Results of the local graft-versus-host reaction support the immunogenetic concept of the insulin-dependent Diabetes mellitus in BB rats.

1984 • 1 citations