Matrix degrading metalloproteinases

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Enzyme nomenclature 1992. Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes.

1992 • 453 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Mechanism of control of trophoblast invasion in situ

1991 • 374 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors.

1993 • 260 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

Purification and properties of a small latent matrix metalloproteinase of the rat uterus.

1988 • 220 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

1992 • 197 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Involvement of extracellular-matrix-degrading metalloproteinases in rabbit aortic smooth-muscle cell proliferation

1992 • 190 citations

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture

1991 • 181 citations

The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.

1992 • 173 citations

Substrate specificities and activation mechanisms of matrix metalloproteinases

1991 • 164 citations

Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2

1991 • 156 citations

Nomenclature and glossary of the matrix metalloproteinases.

1992 • 139 citations

Immunolocalization of metalloproteinases and their inhibitor in the rabbit growth plate.

1989 • 125 citations

Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase.

1990 • 121 citations

Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro.

1992 • 109 citations

Protease production by cultured microglia: Substrate gel analysis and immobilized matrix degradation

1993 • 83 citations

Secretion of matrix metalloproteinases by human endometrial cells in vitro

1993 • 75 citations

α2-Macroglobulin and Tissue Inhibitor of Metalloproteinases: Collagenase Inhibitors in Human Preovulatory Ovaries*

1990 • 69 citations

Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein

1993 • 54 citations

The presence and possible functions of the matrix metalloproteinase collagenase activator protein in developing enamel matrix

1989 • 44 citations

Expressions of Matrilysin and Stromelysin in Human Glioma Cells

1993 • 42 citations