The Selective Interaction of Neurosteroids with the GABAA Receptor

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

GABA_A Receptor Channels

1994 • 1,948 citations

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

1992 • 1,525 citations

Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

1995 • 1,277 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

Which GABAA-receptor subtypes really occur in the brain?

1996 • 1,183 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum

1992 • 673 citations

Bridging the cleft at GABA synapses in the brain

1994 • 622 citations

Methods in Neurosciences

1992 • 622 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.

1991 • 548 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

1991 • 521 citations

Neurosteroids act on recombinant human GABAA receptors

1990 • 515 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Functional domains of GABAA receptors

1995 • 485 citations

The impact of receptor desensitization on fast synaptic transmission

1996 • 478 citations

AMPA and kainate receptors

1995 • 460 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function.

1997 • 431 citations

Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit

1997 • 402 citations

The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

1997 • 382 citations

Anesthetic Effect of Steroid Hormones.

1941 • 363 citations

Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation.

1994 • 343 citations

NMDA receptors: from genes to channels

1996 • 319 citations

Neurosteroids

1994 • 310 citations

Modulation of the GABA_A receptor by depressant barbiturates and pregnane steroids

1988 • 296 citations

Synthesis, metabolism, and pharmacological activity of 3.alpha.-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

1990 • 295 citations

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

1992 • 272 citations

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

1997 • 245 citations

Modulation of the GABA _A receptor by progesterone metabolites

1987 • 245 citations

GABAA/Benzodiazepine receptor heterogeneity: Neurophysiological implications

1995 • 245 citations

Neurosteroid regulation of GABAA receptor single‐channel kinetic properties of mouse spinal cord neurons in culture.

1992 • 241 citations

The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.

1994 • 235 citations

Subunit‐dependent interaction of the general anaesthetic etomidate with the γ‐aminobutyric acid type A receptor

1997 • 234 citations

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture.

1989 • 216 citations

Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone.

1990 • 210 citations

Neurosteroids and GABA, receptor function

1995 • 210 citations

Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABA_AReceptor Subunit Conferring Atypical Functional Properties

1997 • 209 citations

The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex

1995 • 205 citations

Modulation of GABA_A receptor activity by alphaxalone

1987 • 196 citations

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

1993 • 194 citations

Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid

1991 • 174 citations

Neurosteroid Prolongs GABA_AChannel Deactivation by Altering Kinetics of Desensitized States

1997 • 173 citations

Potentiation of gamma‐aminobutyric‐acid‐activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.

1987 • 169 citations

δ Subunit Inhibits Neurosteroid Modulation of GABA_AReceptors

1996 • 158 citations

Actions of synthetic and endogenous steroids on the GABAA receptor

1987 • 146 citations

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

1987 • 144 citations

Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?

1993 • 140 citations

Recent advances in the electrophysiological characterization of 5-HT3 receptors

1992 • 123 citations

Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.

1995 • 117 citations

Regional gamma-aminobutyric acid sensitivity of t-butylbicyclophosphoro[35S]thionate binding depends on gamma-aminobutyric acidA receptor alpha subunit.

1993 • 106 citations

Progesterone 5-α-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes

1994 • 104 citations

Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.

1996 • 96 citations

Neurosteroids: Biosynthesis and Function

1994 • 94 citations

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

1994 • 89 citations

Actions of anaesthetics and avermectin on GABA_A chloride channels in mammalian dorsal root ganglion neurones

1989 • 88 citations

Differential antagonism by epipregnanolone of alphaxalone and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding site for steroids at GABAA receptors

1993 • 85 citations

Steroid Modulation of the GABA _A Receptor Complex: Electrophysiological Studies

2007 • 83 citations

Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes

1996 • 83 citations

Effects of steroids on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina.

1992 • 81 citations

Modulation of GABAA receptor‐mediated IPSCs by neuroactive steroids in a rat hypothalamo‐hypophyseal coculture model.

1997 • 76 citations

Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes.

1997 • 75 citations

Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABA_A Receptor

1997 • 61 citations

Transmitter amino acid receptors : structures, transduction, and models for drug development

1991 • 61 citations

GABA[A] receptors and anxiety : from neurobiology to treatment

1995 • 59 citations

Secondary Activation of a Cation Conductance Is Responsible for NMDA Toxicity in Acutely Isolated Hippocampal Neurons

1997 • 56 citations

The transmitter-gated channels: a range of receptor types and structures

1996 • 56 citations

Modulation of Human Recombinant GABA A Receptors by Pregnanediols

1996 • 53 citations

Anesthetic Activity of Novel Water-Soluble 2β-Morpholinyl Steroids and Their Modulatory Effects at GABA_A Receptors

1997 • 50 citations

Neuroactive steroid modulation of GABAA receptors.

1995 • 49 citations

Steroid modulation of the strychnine-sensitive glycine receptor

1992 • 49 citations

Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus‐response coupling of insulin release

1996 • 48 citations

3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones: Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABA_A Receptors

1997 • 44 citations

The Anaesthetic Action and Modulation of GABA A Receptor Activity by the Novel Water-soluble Aminosteroid Org 20599

1996 • 35 citations

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

1996 • 35 citations

Steroids and neuronal activity (Ciba foundation symposium 153)

1991 • 34 citations

Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.

1995 • 28 citations

Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons.

1992 • 27 citations

Effects of Neurosteroid and Benz[ e ]indene Enantiomers on GABA A Receptors in Cultured Hippocampal Neurons and Transfected HEK-293 Cells

1996 • 24 citations

Effect of steroids on ?-aminobutyrate-induced currents in cultured rat astrocytes

1991 • 24 citations

The mechanism of steroid anaesthetic (alphaxalone) block of acetylcholine‐induced ionic currents

1984 • 23 citations

Water-soluble steroidal anaesthetics

1979 • 21 citations

Neurobiology of steroids

1994 • 17 citations

Electrophysiological Studies of Neurosteroid Modulation of γ-Aminobutyric Acid Type A Receptor

1994 • 14 citations

The GABA<sub>A</sub> Receptor: An Important Locus for Intravenous Anaesthetic Action

2011 • 7 citations