The mechanism of steroid anaesthetic (alphaxalone) block of acetylcholine‐induced ionic currents

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junction

1973 • 992 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Anesthetic Effect of Steroid Hormones.

1941 • 363 citations

Drug blockade of open end‐plate channels.

1976 • 352 citations

On the mechanism of desensitization at cholinergic receptors.

1970 • 247 citations

A Unitary Theory of Anesthesia Based on Lateral Phase Separations in Nerve Membranes

1977 • 235 citations

A quantitative analysis of local anaesthetic alteration of miniature end‐plate currents and end‐plate current fluctuations.

1977 • 169 citations

A re-examination of curare action at the motor endplate

1978 • 150 citations

Determination of dose‐response curves by quantitative ionophoresis at the frog neuromuscular junction.

1978 • 147 citations

Molecular Mechanisms of Anesthesia

1981 • 140 citations

ANAESTHETICS DEPRESS THE SENSITIVITY OF CORTICAL NEURONES TO <scp>l</scp>‐GLUTAMATE

1976 • 139 citations

Steroid Anesthetics

1975 • 103 citations

Analysis of atropine action at the frog neutromuscular junction.

1977 • 80 citations

Physiological aspects of steroids with anaesthetic properties.

1976 • 78 citations

Action of Some Steroids on the Central Nervous System of the Mouse. II. Pharmacology

1965 • 78 citations

Kinetic analysis of end plate currents altered by atropine and scopolamine.

1978 • 70 citations

Structurally specific effects of some steroid anesthetics on spin-labeled liposomes.

1975 • 64 citations

Implications for theories of anaesthesia of antagonism between anaesthetic and non-anaesthetic steroids

1975 • 60 citations

The relationship between desensitization and the metaphilic effect at cholinergic receptors.

1970 • 60 citations

Quinacrine (mepacrine) action at frog end‐plate.

1980 • 57 citations

THE KINETICS OF LOCAL ANESTHETIC BLOCKADE OF END-PLATE CHANNELS

1982 • 51 citations

Molecular Mechanisms in General Anesthesia

1975 • 51 citations

THE PHYSIOLOGICAL ACTION OF CHOLESTEROL

1927 • 51 citations

PRESYNAPTIC EFFECT OF I.V. ANAESTHETIC AGENTS AT THE NEUROMUSCULAR JUNCTION

1979 • 46 citations

POSTSYNAPTIC EFFECT OF I.V. ANAESTHETIC AGENTS AT THE NEUROMUSCULAR JUNCTION

1977 • 41 citations

Facilitation of synaptic transmission by general anaesthetics.

1978 • 35 citations

GENERAL ANAESTHETICS AND THE ACETYLCHOLINE‐SENSITIVITY OF CORTICAL NEURONES

1976 • 35 citations

ADDITIVE AND NON‐ADDITIVE EFFECTS OF MIXTURES OF SHORT‐ACTING INTRAVENOUS ANAESTHETIC AGENTS AND THEIR SIGNIFICANCE FOR THEORIES OF ANAESTHESIA

1981 • 33 citations

COMPARISON OF DESENSITIZATION AND TIME‐DEPENDENT BLOCK OF THE ACETYLCHOLINE RECEPTOR RESPONSES BY CHLORPROMAZINE, CYTOCHALASIN B, TRITON X‐100 AND OTHER AGENTS

1980 • 31 citations

Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.

1978 • 28 citations

Acetylcholine noise in cultured chick myoballs: a voltage clamp analysis.

1978 • 28 citations

Extrinsic and intrinsic acetylcholine and barbiturate effects on frog skeletal muscle.

1970 • 22 citations

Motor Innervation of Muscle

1978 • 9 citations

The labilization of lecithin liposomes by steroidal anaesthetics: A correlation with anaesthetic activity

1974 • 9 citations

Steroid anaesthetics: inhibition of depolarization–secretion coupling at the mouse motor nerve terminal

1980 • 5 citations

Non-additive anaesthetic effects of alphaxalone and methohexitone [proceedings].

1977 • 2 citations

A potentiation of inhibition by various anaesthetics in the isolated olfactory cortex [proceedings].

1978 • 1 citations