Retrovirus-Induced B Cell Neoplasia in the Bursa of Fabricius

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

1987 • 693 citations

Control of c-myc Regulation in Normal and Neoplastic Cells

1991 • 632 citations

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

1982 • 624 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Increased ratio of targeted to random integration after transfection of chicken B cell lines

1991 • 534 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis

1985 • 469 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

A VIRUS IN CHICK EMBRYOS WHICH INDUCES RESISTANCE IN VITRO TO INFECTION WITH ROUS SARCOMA VIRUS

1960 • 380 citations

Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

1984 • 368 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines

1983 • 297 citations

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

1987 • 278 citations

Light chain gene conversion continues at high rate in an ALV-induced cell line.

1990 • 226 citations

Molecular biology of tumor viruses. RNA tumor viruses.

1982 • 224 citations

Bursal and postbursal stem cells in chicken. functional characteristics

1973 • 197 citations

The Chicken B Cell Compartment

1987 • 172 citations

Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.

1989 • 172 citations

Resistance to a Malignant Lymphoma in Chickens Is Mapped to Subregion of Major Histocompatibility ( B ) Complex

1983 • 167 citations

Induction of apoptosis during normal and neoplastic B-cell development in the bursa of Fabricius.

1991 • 153 citations

Analysis of the defectiveness of rous sarcoma virus III. Determining influence of a new helper virus on the host range and susceptibility to interference of RSV

1965 • 151 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS, II. SPECIFICATION OF RSV ANTIGENICITY BY HELPER VIRUS

1964 • 132 citations

Effect of Bursectomy and Thymectomy on the Development of Visceral Lymphomatosis in the Chicken2

1964 • 123 citations

Patterns of proviral insertion and deletion in avian leukosis virus-induced lymphomas

1986 • 122 citations

Isolation and characterization of the chickenbcl–2gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo

1992 • 118 citations

A recovered avian myelocytomatosis virus that induces lymphomas in chickens: pathogenic properties and their molecular basis

1983 • 114 citations

Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.

1984 • 111 citations

Clones of B lymphocytes in individual follicles of the bursa of Fabricius

1985 • 99 citations

Relationships Among Visceral Lymphomatosis, Bursa of Fabricius, and Bursa-Dependent Lymphoid Tissue of the Chicken2

1966 • 96 citations

Nucleotide sequence 5' of the chicken c-myc coding region: localization of a noncoding exon that is absent from myc transcripts in most avian leukosis virus-induced lymphomas.

1984 • 88 citations

Differential transcription from the long terminal repeats of integrated avian leukosis virus DNA

1986 • 86 citations

Pathogenesis of Avian Lymphoid Leukosis. I. Histogenesis<xref ref-type="fn" rid="FN2">2</xref>

1968 • 84 citations

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.

1990 • 78 citations

The effect of alterations in myc gene expression on B cell development in the bursa of fabricius

1987 • 71 citations

Molecular analysis of the c-myc locus in normal tissue and in avian leukosis virus-induced lymphomas

1982 • 69 citations

RAV-1 insertional mutagenesis: disruption of the c-myb locus and development of avian B-cell lymphomas

1989 • 69 citations

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture.

1992 • 67 citations

Effect of in ovo treatment with cyclophosphamide on lymphoid system in chicken

1974 • 66 citations

Formation of a transformed follicle is necessary but not sufficient for development of an avian leukosis virus-induced lymphoma.

1985 • 62 citations

Viral DNA in bursal lymphomas induced by avian leukosis viruses

1980 • 61 citations

Augmentation of retrovirus-induced lymphoid leukosis by Marek's disease herpesviruses in White Leghorn chickens

1989 • 56 citations

A retroviral myc gene induces preneoplastic transformation of lymphocytes in a bursal transplantation assay.

1985 • 51 citations

Influence of Congenital Transmission of Endogenous Virus-21 on the Immune Response to Avian Leukosis Virus Infection and the Incidence of Tumors in Chickens

1988 • 50 citations

Defect in the generation of light-chain diversity in bursectomized chickens

1984 • 48 citations

Egg Transmission of Avian Lymphomatosis

1954 • 42 citations

Pathogenicity of a Viral Strain (RPL12) Causing Avian Visceral Lymphomatosis and Related Neoplasms. III. Influence of Host Age and Route of Inoculation

1960 • 41 citations

Expression of v-rel induces mature B-cell lines that reflect the diversity of avian immunoglobulin heavy- and light-chain rearrangements.

1988 • 40 citations

Chicken leukosis virus genome sequences in DNA from normal chick cells and virus-induced bursal lymphomas

1975 • 39 citations

The Development of a Chicken Flock Apparently Free of Leukosis Virus

1963 • 38 citations

Post-infection genetic resistance to avian lymphoid leukosis resides in B target cell

1977 • 35 citations

The Role of the Infected Egg in the Transmission of Visceral Lymphomatosis

1955 • 35 citations

Tissue-specific lability and expression of avian leukosis virus long terminal repeat enhancer-binding proteins.

1989 • 33 citations

Differential response to avian leukosis virus infection exhibited by two chicken lines

1984 • 32 citations

Lability of leukosis virus enhancer-binding proteins in avian hematopoeitic cells

1988 • 31 citations

Transcriptional interaction between retroviral long terminal repeats (LTRs): mechanism of 5' LTR suppression and 3' LTR promoter activation of c-myc in avian B-cell lymphomas

1992 • 30 citations

a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer

1992 • 26 citations

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

1982 • 25 citations

Genetic Influence of the Rs Locus on Susceptibility to Avian Tumor Viruses. I. Neoplasms Induced by RPL12 and Three Strains of Rous Sarcoma Virus

1965 • 24 citations

Activation of the c-myb locus is insufficient for the rapid induction of disseminated avian B-cell lymphoma

1992 • 23 citations

Persistence of Marek's disease virus in a subpopulation of B cells that is transformed by avian leukosis virus, but not in normal bursal B cells

1992 • 21 citations

Effects of age at infection with serotype 2 Marek's disease virus on enhancement of avian leukosis virus‐induced lymphomas

1993 • 14 citations

Recent advances in the genetics of disease resistance¹

1983 • 12 citations

Bursal Stem Cells as Targets for myc-Induced Preneoplastic Proliferation and Maturation Arrest

1988 • 11 citations

The Avian Leucosis Complex

1964 • 10 citations

The History of Avian Medicine in the United States V. Insights into Avian Tumor Virus Research

1979 • 10 citations

An aberrant avian leukosis virus provirus inserted downstream from the chicken c-myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA

1987 • 8 citations

The prevention of natural and experimental avian lymphoid leukosis with the androgen analogue mibolerone¹

1978 • 8 citations

Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.

1988 • 6 citations