Chapter 5 Proteinase inhibitors

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR

1947 • 2,416 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Wound-Induced Proteinase Inhibitor in Plant Leaves: A Possible Defense Mechanism against Insects

1972 • 1,167 citations

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1973 • 1,062 citations

Toxic constituents of plant foodstuffs

1981 • 908 citations

CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR

1946 • 710 citations

Structural basis of the activation and action of trypsin

1978 • 669 citations

Evolution of Proteolytic Enzymes

1984 • 641 citations

Crystallographic refinement of the structure of bovine pancreatic trypsin inhibitor at l.5 Å resolution

1975 • 544 citations

ISOLATION FROM BEEF PANCREAS OF CRYSTALLINE TRYPSINOGEN, TRYPSIN, A TRYPSIN INHIBITOR, AND AN INHIBITOR-TRYPSIN COMPOUND

1936 • 518 citations

Toxic constituents of plant foodstuffs

1981 • 510 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Proteolytic Enzymes and Their Inhibitors in Plants

1973 • 414 citations

The Bowman‐Birk inhibitor. Trypsin‐ and chymotrypsin‐inhibitor from soybeans

1985 • 381 citations

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

1982 • 352 citations

[54] α2-Macroglobulin

1981 • 316 citations

Enzyme inhibitors of microbial origin

1972 • 314 citations

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding

1978 • 301 citations

Isolation of a Crystalline Trypsin Inhibitor-Anticoagulant Protein from Pancreas^1a

1948 • 300 citations

The Basic Trypsin Inhibitor of Bovine Pancreas

1963 • 289 citations

The proteinase inhibitors of plants and micro-organisms

1977 • 281 citations

Crystallization of a Trypsin Inhibitor from Soybean

1945 • 259 citations

Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges

1972 • 251 citations

THE USE OF SOY BEAN AS FOOD

1917 • 219 citations

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

1982 • 206 citations

Natural Proteinase Inhibitors

1968 • 202 citations

Refined 2.5 Å X-ray crystal structure of the complex formed by porcine kallikrein A and the bovine pancreatic trypsin inhibitor

1983 • 199 citations

Studies on Soybean Trypsin Inhibitors

1973 • 199 citations

Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-.ANG. resolution

1983 • 193 citations

Proteinase inhibitor-inducing factor activity in tomato leaves resides in oligosaccharides enzymically released from cell walls

1981 • 187 citations

Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 Å resolution

1982 • 186 citations

The Trypsin and Chymotrypsin Inhibitors from Avian Egg Whites

1960 • 180 citations

Chitosans and pectic polysaccharides both induce the accumulation of the antifungal phytoalexin pisatin in pea pods and antinutrient proteinase inhibitors in tomato leaves

1983 • 177 citations

Purification and some properties of a highly active inhibitor of trypsin and α-chymotrypsin from soybeans

1961 • 174 citations

A pure trypsin inhibitor from soya beans

1963 • 174 citations

The physiological inhibitors of blood coagulation and fibrinolysis

1991 • 173 citations

The basic trypsin inhibitor of bovine pancreas V. The disulfide linkages

1965 • 159 citations

Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro.

1985 • 155 citations

Properties of Isolated Human alpha1-Antitrypsins of Pi Types M, S and Z

1978 • 144 citations

Crystallographic refinement of Japanese quail ovomucoid, a Kazal-type inhibitor, and model building studies of complexes with serine proteases

1982 • 142 citations

Purification and Properties of a Carboxypeptidase Inhibitor from Potatoes

1974 • 139 citations

Induction of the bovine trypsinogen—trypsin transition by peptides sequentially similar to the N‐terminus of trypsin

1976 • 137 citations

Proteinase inhibitors: Medical and biological aspects

1984 • 136 citations

Proteinase inhibitors I and II from leaves of wounded tomato plants: Purification and properties

1982 • 133 citations

Inhibition of Human Trypsin, Plasmin, and Thrombin by Naturally Occurring Inhibitors of Proteolytic Enzymes

1969 • 133 citations

The complete amino acid sequence of the bifunctional α‐amylase/trypsin inhibitor from seeds of ragi (Indian finger millet, Eleusine coracana Gaertn.)

1983 • 126 citations

Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis

1985 • 125 citations

Comparative Study on Amino Acid Sequences of Kunitz-Type Soybean Trypsin Inhibitors, Tia, Tib, and Tic1

1985 • 125 citations

Studies on Soybean Trypsin Inhibitors

1972 • 124 citations

Effect of Human Granulocytic Elastase on Isolated Human Antithrombin III

1981 • 122 citations

The squash family of serine proteinase inhibitors. Amino acid sequences and association equilibrium constants of inhibitors from squash, summer squash, zucchini, and cucumber seeds

1985 • 120 citations

The crystal and molecular structure of the third domain of silver pheasant ovomucoid (OMSVP3)

1985 • 119 citations

Proteinase inhibitors in plant leaves: A biochemical model for pest-induced natural plant protection

1978 • 119 citations

Enzymic replacement of the arginyl by a lysyl residue in the reactive site of soybean trypsin inhibitor

1969 • 115 citations

Fractionation and Properties of Trypsin and Chymotrypsin Inhibitors from Lima Beans

1967 • 114 citations

Mode of action of soybean trypsin inhibitor (Kunitz) as a model for specific protein–protein interactions

1974 • 112 citations

Fractions Derived from Soy Beans and Navy Beans Which Retard Tryptic Digestion of Casein

1944 • 109 citations

The Inter-α-Trypsin Inhibitor as Precursor of the Acid-Stable Proteinase Inhibitors in Human Serum and Urine

1976 • 108 citations

Structural studies of the sugar chains of hen ovomucoid. Evidence indicating that they are formed mainly by the alternate biosynthetic pathway of asparagine-linked sugar chains.

1983 • 108 citations

Amino acid sequence and secondary structural analysis of the corn inhibitor of trypsin and activated Hageman Factor.

1984 • 101 citations

The Structure of the Bovine Pancreatic Secretory Trypsin Inhibitor—Kazal's Inhibitor

1969 • 97 citations

Natural plant enzyme inhibitors. Characterization of an unusual α-amylase/trypsin inhibitor from ragi (Eleusine coracana Geartn.)

1981 • 96 citations

[52] Human α2-macroglobulin

1976 • 96 citations

The complete amino acid sequence of barley trypsin inhibitor.

1983 • 95 citations

Isolation of a genomic clone for bovine pancreatic trypsin inhibitor by using a unique-sequence synthetic DNA probe.

1983 • 94 citations

Biochemistry of Natural Proteinase Inhibitors

1974 • 94 citations

Mechanism of action of naturally occurring proteinase inhibitors. Anhydrotrypsin and anhydrochymotrypsin purified by affinity chromatography

1974 • 94 citations

Purification, partial characterization, and immunological relationships of multiple low molecular weight protease inhibitors of soybean

1977 • 89 citations

Isolation and characterization of a trypsin inhibitor from lima beans

1952 • 85 citations

The complete amino acid sequence of a major wheat protein inhibitor of α-amylase

1981 • 84 citations

A Sycamore Cell Wall Polysaccharide and a Chemically Related Tomato Leaf Polysaccharide Possess Similar Proteinase Inhibitor-Inducing Activities

1981 • 83 citations

Basic pancreatic trypsin inhibitor has unusual thermodynamic stability parameters

1983 • 82 citations

Scission of Soybean Bowman-Birk Proteinase Inhibitor into Two Small Fragments Having Either Trypsin or Chymotrypsin Inhibitory Activity

1973 • 79 citations

[58] Carboxypeptidase inhibitor from potatoes

1981 • 78 citations

Isolation and characterization of the trypsin inhibitors from winged bean seed (Psophocarpus tetragonolobus (L) Dc.)

1979 • 76 citations

Crystallization, crystal structure analysis and molecular model of the third domain of Japanese quail ovomucoid, a Kazal type inhibitor

1981 • 75 citations

Further evidence for a dual, independent, activity against trypsin and α-chymotrypsin of inhibitor AA from soybeans

1967 • 75 citations

Ultrastructural localization of Kunitz inhibitor on thin sections of Glycine max (soybean) cv. Maple Arrow by the gold method

1983 • 73 citations

The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1975 • 72 citations

An Undescribed Trypsin Inhibitor in Egg White

1958 • 71 citations

Turkey ovomucoid third domain inhibits eight different serine proteinases of varied specificity on the same ...Leu18-Glu19... reactive site

1985 • 70 citations

Isolation and characterization from potato tubers of two polypeptide inhibitors of serine proteinases

1982 • 70 citations

Studies on Soybean Trypsin Inhibitors

1977 • 67 citations

Immunofluorescence Studies Indicate that the Basic Trypsin-Kallikrein-Inhibitor of Bovine Organs (Trasylol) Originates from Mast Cells

1979 • 67 citations

Amino Acid Sequences of Trypsin-Chymotrypsin Inhibitors (A-I, A-II, B-I, and B-II) from Peanut (Arachis hypogaea)1: A Discussion on the Molecular Evolution of Legume Bowman-Birk Type Inhibitors

1983 • 66 citations

[56] Proteinase inhibitors from plant sources

1976 • 65 citations

Wound-induced trypsin inhibitor in alfalfa leaves: Identity as a member of the Bowman-Birk inhibitor family

1985 • 64 citations

Interaction between serine (pro)enzymes, and kazal and kunitz inhibitors

1983 • 64 citations

Primary amino acid sequence similarity between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor, and members of porcine secretin family

1983 • 62 citations

The partial amino acid sequence of trypsin inhibitor II from garden bean, Phaseolus vulgaris, with location of the trypsin and elastase-reactive sites

1975 • 61 citations

Pumpkin seed inhibitor of human factor XIIa (activated Hageman factor) and bovine trypsin

1982 • 59 citations

ISOLATION AND CHARACTERIZATION OF A NEW TRYPSIN‐LIKE ENZYME FROM: Tenebrio molitor L. LARVAE

1977 • 58 citations

Accumulation of a metallo-carboxypeptidase inhibitor in leaves of wounded potato plants

1981 • 58 citations

Studies on Soybean Trypsin Inhibitors

1977 • 58 citations

Isolation and characterization of a wound-induced trypsin inhibitor from alfalfa leaves

1984 • 56 citations

Stopped-flow kinetics of the resynthesis of the reactive site peptide bond in kallikrein inhibitor (Kunitz) by β-trypsin

1978 • 56 citations

Isolation and Characterization of Porcine Proelastase

1970 • 56 citations

Replacement of Lysine by Arginine, Phenylalanine and Tryptophan in the Reactive Site of the Bovine Trypsin‐Kallikrein Inhibitor (Kunitz) and Change of the Inhibitory Properties

1976 • 56 citations

Molecular cloning and analysis of a gene coding for the Bowman-Birk protease inhibitor in soybean.

1984 • 55 citations

SHORT COMMUNICATION

1983 • 54 citations

Soybean trypsin inhibitor (Kunitz) and its complex with trypsin. Carbon-13 nuclear magnetic resonance studies of the reactive site arginine

1980 • 53 citations

A trypsin and chymotrypsin inhibitor from chick peas (Cicer arietinum)

1976 • 53 citations

Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution.

1980 • 53 citations

Soybean Inhibitors

1969 • 52 citations

The inhibitory properties of avian ovoinhibitors against proteolytic enzymes

1971 • 52 citations

The primary structure of Vipera ammodytes venom trypsin inhibitor I

1983 • 52 citations

The Amino Acid Sequences of Two Soybean Double Headed Proteinase Inhibitors and Evolutionary Consideration on the Legume Proteinase Inhibitors

1976 • 49 citations

Studies on Soybean Trypsin Inhibitors

1978 • 47 citations

Human Inter-α-Trypsin Inhibitor: Localization of the Kunitz-Type Domains in the N-terminal Part of the Molecule and their Release by a Trypsin-Like Proteinase

1985 • 46 citations

Acacia proteinase inhibitors. Purification and properties of the trypsin inhibitors from Acacia elata seed.

1981 • 45 citations

Snake Venoms. The Amino-Acid Sequence of Trypsin Inhibitor E of Dendroaspis polylepis polylepis (Black Mamba) Venom

1978 • 44 citations

The complete amino acid sequence and the trypsin reactive (inhibitory) site of the major proteinase inhibitor from the fruits of aubergine (Solanum melongena L.)

1979 • 44 citations

Ueber die Enzyme

1894 • 41 citations

[66] Naturally occurring inhibitors of proteolytic enzymes

1970 • 40 citations

Isolation and partial amino acid sequence of the trypsin inhibitor from the seeds of Cucurbita maxima.

1980 • 38 citations

Acacia Proteinase Inhibitors

2005 • 37 citations

Studies on Soybean Trypsin Inhibitors

1978 • 37 citations

A basic trypsin- and chymotrypsin-inhibitor from groundnuts (Arachis hypogaea)

1972 • 37 citations

General Properties of a Protease Inhibitor from the Seeds of Kidney Bean

1968 • 36 citations

Proteaseinhibitors in potatoes Protein-, Trypsin- und Chymotrypsininhibitorenmuster durch isoelektrisches Fokussieren in Polyacrylamidgel. Eine Schnellmethode zur Identifizierung von Kartoffelsorten

1974 • 34 citations

Chemical-enzymic replacement of Ile⁶⁴ in the reactive site of soybean trypsin inhibitor (Kunitz)

1976 • 33 citations

Inhibition spectra of the human pancreatic endopeptidases

1975 • 32 citations

Purification and Some Properties of Two Proteinase Inhibitors (DE-1 and DE-3) fromErythrina latissima(Broad-Leaved Erythrina) Seed

1981 • 30 citations

Chicken α2-proteinase inhibitor: A serum protein homologous with ovoinhibitor of egg white

1974 • 30 citations

The Effect of Feeding Soybean Trypsin Inhibitor and Repeated Injections of Cholecystokinin on Rat Pancreas

1984 • 29 citations

TRYPSIN AND CHYMOTRYPSIN INHIBITOR FROM CHICK PEAS Selective Chemical Modifications of the Inhibitor and Isolation of Two Isoinhibitors

1979 • 27 citations

Plant inhibitors of serine proteinases: hageman factor fragment, kallikreins, plasmin, thrombin, factor Xa, trypsin, and chymotrypsin

1980 • 27 citations

Trypsin inhibitors in summer squash (Cucurbita pepo) seeds. Isolation, purification and partial characterization of three inhibitors.

1984 • 26 citations

Amino Acid Sequence of a Trypsin-Chymotrypsin Inhibitor, B-III, of Peanut (Arachis hypogaea)1

1983 • 26 citations

Comparative Inhibition of Trypsins from Several Species by Soybean Trypsin Inhibitors

1983 • 26 citations

Purification and Characterization of Protease Inhibitors from Peanuts (Arachis hypogaea)1

1982 • 25 citations

Metabolic Interconversion of Enzymes 1975

1976 • 25 citations

The Basic Trypsin Inhibitor of Bovine Pancreas

1968 • 25 citations

Wound-Regulated Synthesis and Vacuolar Compartmentation of Proteinase Inhibitors in Plant Leaves

1980 • 25 citations

Soybean trypsin inhibitor (Kunitz) is doubleheaded

1981 • 25 citations

Purification and properties of the proteinase inhibitors from Erythrina caffra (coast erythrina) seed

1982 • 25 citations

Purification and Characterization of the Carboxypeptidase Isoinhibitors from Potatoes

1979 • 24 citations

The Basic Trypsin Inhibitor of Bovine Pancreas IX. LOCATION OF THE REACTIVE SITE IN THE CARBOXAMIDOMETHYL DERIVATIVE

1968 • 22 citations

Elastases from Human and Canine Granulocytes, II. Interaction with Protease Inhibitors of Animal, Plant, and Microbial Origin

1977 • 22 citations

[79] Broad-specificity inhibitors from sea anemones

1976 • 21 citations

Chemical Substitutions of the Reactive Site Leucine Residue in Soybean Bowman-Birk Proteinase Inhibitor with Other Amino Acids1

1980 • 21 citations

Synthesis and characterization of a pancreatic trypsin inhibitor homolog and a model inhibitor

1977 • 21 citations

Preparation and characteristics of trypsin inhibitors from the seeds of squash (Cucurbita maxima) and zucchini (Cucurbita pepo var. Giromontia).

1983 • 21 citations

STUDIES ON THE SYNTHESIS OF PROTEINASE INHIBITORS

1980 • 20 citations

Isolation and characterization of genetic variants of the kunitz soybean trypsin inhibitor

1980 • 20 citations

The fate of the bowman-birk trypsin inhibitor from soybeans in the digestive tract of chicks

1979 • 20 citations

Sequence homology between barley trypsin inhibitor and wheat α‐amylase inhibitors

1982 • 20 citations

Soybean inhibitors

1969 • 19 citations

Ovomucoid and ovoinhibitor isolated from chicken egg white are immunologically cross-reactive

1983 • 19 citations

Stoichiometry of Interaction of Chicken Ovoinhibitor with Pancreatic Trypsin, Chymotrypsin and Elastase I

1980 • 19 citations

Amino acid sequences of proteinase inhibitors II and II' from adzuki beans.

1979 • 19 citations

Azuki Bean (Vigna angularis1) Protease Inhibitors: Isolation and Amino Acid Sequences

1985 • 19 citations

Structure of potato carboxypeptidase inhibitor: disulfide pairing and exposure of aromatic residues

1979 • 17 citations

Über pflanzliche Proteaseninhibitoren, VI. Reindarstellung der polyvalenten Proteaseninhibitoren ausArachis hypogaea

1969 • 17 citations

A synthetic 13-residue peptide designed to resemble the primary binding site of the basic pancreatic trypsin inhibitor

1982 • 16 citations

Über pflanzliche Proteaseninhibitoren, VIII. Die Aminosäuresequenz des Trypsininhibitors aus Samen vonArachis hypogaea

1970 • 16 citations

Isolation and partial characterization of the pancreatic secretory trypsin inhibitor in the rat

1982 • 16 citations

Structural homology of a trypsin‐plasmin inhibitor from leeches (bdellin B‐3) with secretory trypsin inhibitors from mammals

1976 • 16 citations

Kunitz-Type Proteinase Inhibitors Derived by Limited Proteolysis of the Inter-α-Trypsin Inhibitor, X. The Amino-Acid Sequences of the Trypsin-Released Inhibitors from Horse and Pig Inter-α-Trypsin Inhibitors

1985 • 15 citations

Isolation and characterization of a new form of the porcine pancreatic secretory trypsin inhibitor Biochemical studies and high-resulution 1H-NMR

1982 • 15 citations

Proteinase inhibitors from Vigna unguiculata subsp. cylindrica

1980 • 14 citations

Formation, crystallization, and preliminary crystallographic data of the ternary complex of alpha-chymotrypsin, beta-trypsin, and the Bowman-Birk inhibitor.

1981 • 14 citations

Proteinase inhibitors from Vigna unguiculata subsp. cylindrica

1980 • 14 citations

CIRCULAR DICHROISM SPECTRA OF TRYPSIN AND CHYMOTRYPSIN COMPLEXES WITH BOWMAN-BIRK OR CHICKPEA TRYPSIN INHIBITOR

1981 • 14 citations

Multifunctional Proteinase Inhibitor from Bauhinia Seeds

1973 • 13 citations

Effects of Feeding a Carboxypeptidase Inhibitor from Potatoes to Newly Hatched Chicks

1983 • 13 citations

In vitro synthesis of the Bowman-Birk and related soybean protease inhibitors

1982 • 13 citations

Anti-tryptic activity of a synthetic bicyclic fragment of soybean bowman-birk inhibitor

1982 • 13 citations

Occurrence of a trypsin inhibitor in eggplant exocarps.

1975 • 13 citations

The Interaction of the Bowman‐Birk Inhibitor with Trypsin and Chymotrypsin

1972 • 12 citations

[76] Proteinase (elastase) inhibitors from dog submandibular glands

1976 • 12 citations

Homologous inhibitors from potato tubers of serine endopeptidases and metallocarboxypeptidases.

1976 • 12 citations

Crystallization of two cubic forms of soybean trypsin inhibitor E-I, a member of the Bowman-Birk inhibitor family.

1983 • 11 citations

Preparation of an Active Fragment of Potato Proteinase Inhibitor IIa and Its Properties

1974 • 11 citations

Immunological Similarities of Proteinase Inhibitors from Potatoes

1976 • 11 citations

Smoking, Pregnancy and Publicity

1973 • 10 citations

Structural Differences between Trypsin Inhibitors Isolated from Cucurbitaceae Family Seeds: Immunological, NMR and CD Studies

1983 • 10 citations

The Reactive Site Amino Acid Sequences of Silktree (Albizzia julibrissin) Seed Proteinase Inhibitors

1980 • 10 citations

CIRCULAR DICHROISM SPECTRA OF ISOLATED SOYBEAN AND CHICKPEA TRYPSIN‐CHYMOTRYPSIN INHIBITORS

1978 • 10 citations

The molecular weight of the Bowman-Birk soybean protease inhibitor

1970 • 9 citations

Inhibition Mechanism of a Peanut Trypsin-Chymotrypsin Inhibitor, B-III: Determination of the Reactive Sites for Trypsin and Chymotrypsin1

1984 • 7 citations

Amino Acid Sequence of an Active Fragment of Potato Proteinase Inhibitor IIa1

1976 • 7 citations

A Possible Evolutionary Relationship between Plant Trypsin Inhibitor, α-Amylase Inhibitor, and Mammalian Pancreatic Secretory Trypsin Inhibitor (Kazal)

1983 • 7 citations

A rapid, large-scale method for purification of the metallo-carboxypeptidase inhibitor from potato tubers

1983 • 7 citations

Preliminary crystallographic data for Bowman-Birk inhibitor from soybean seeds.

1979 • 6 citations

Purification, Characterization and Sequence Determination of a Double-headed Trypsin Inhibitor Peptide fromTrichosanthes kirilowii(a Chinese Medical Herb)

1984 • 5 citations

Isolation of pancreatic trypsin inhibitor from bovine pituitary glands.

1983 • 5 citations

Photoreactive derivative of Kunitz's soybean trypsin inhibitor. Preparation by selective modification of a tryptophan residue and formation of a covalent complex of the modified inhibitor with trypsin.

1984 • 4 citations

Detection of bovine pancreatic trypsin inhibitor (bPTI) in bovine and ovine pituitaries, bovine brain, and adrenal medulla. A specific radioimmunoassay for bPTI

1984 • 4 citations

Photoreactive derivative of Kunitz's soybean trypsin inhibitor.

1984 • 4 citations

Preparation of photoreactive derivatives of trypsin‐chymotrypsin inhibitors from soybeans and chick peas by selective modification of lysine residues

1985 • 4 citations

Preliminary Crystallographic Study of Bowman-Birk Protease Inhibitor (Adzuki Bean) and Its Complex with Trypsin

1983 • 3 citations

[68] Albumin gland inhibitor from snails (Helix pomatia)

1976 • 1 citations