Role of natural killer (NK) cells in the control of tumor growth and metastatic spread

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).

1981 • 1,411 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Natural Cell-Mediated Immunity

1978 • 1,063 citations

Characteristics of human large granular lymphocytes and relationship to natural killer and K cells

1981 • 1,008 citations

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1970 • 990 citations

Interleukin-2 augments natural killer cell activity

1981 • 921 citations

Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens.

1983 • 852 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 676 citations

Natural Cell-mediated Immunity Against Tumors

1980 • 666 citations

NK Cells and Other Natural Effector Cells

1982 • 624 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 590 citations

Natural Killer Cells: Characteristics and Regulation of Activity

1979 • 582 citations

A glycolipid on the surface of mouse natural killer cells

1980 • 539 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Isolation of human NK cells by density gradient centrifugation

1980 • 462 citations

Platelet—tumor‐cell interactions in mice. The role of platelets in the spread of malignant disease

1973 • 447 citations

Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison.

1980 • 425 citations

In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

1981 • 424 citations

Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies.

1981 • 397 citations

Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo.

1981 • 395 citations

Role of Natural Killer Cells in the Destruction of Circulating Tumor Emboli23

1980 • 389 citations

Role of NK cells in the control of metastatic spread and growth of tumor cells in mice

1982 • 357 citations

An Analysis of the Murine NK Cell as to Structure, Function and Biological Relevance

1979 • 351 citations

Prostacyclin: A Potent Antimetastatic Agent

1981 • 335 citations

Immunologic Mechanisms in UV Radiation Carcinogenesis

1981 • 295 citations

Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells.

1981 • 284 citations

Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver.

1985 • 275 citations

Role of Platelets in Tumor Cell Metastases

1981 • 266 citations

Role of plasma, platelets, and endothelial cells in tumor metastasis

1984 • 260 citations

Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber.

1958 • 252 citations

Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells.

1981 • 234 citations

Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non‐immunized semi‐syngeneic mice against a mouse lymphoma line

1975 • 230 citations

Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria.

1982 • 223 citations

Identification of ganglio-N-tetraosylceramide as a new cell surface marker for murine natural killer (NK) cells.

1980 • 220 citations

beta-Estradiol reduces natural killer cells in mice.

1978 • 216 citations

Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages.

1974 • 205 citations

Identification of a cell-surface antigen selectively expressed on the natural killer cell.

1977 • 196 citations

Discrimination Between Neoplastic and Non-Neoplastic Cells In Vitro by Activated Macrophages12

1974 • 191 citations

Role of natural killer cells in control of cancer metastasis

1982 • 190 citations

Monoclonal antibodies which distinguish between human NK cells and cytotoxic T lymphocytes

1980 • 189 citations

Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell‐mediated cytotoxicity

1980 • 179 citations

Role of macrophages in the augementation of mouse natural killer cell activity by poly I:C and interferon.

1979 • 170 citations

Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver.

1984 • 167 citations

In vivo role of natural killer cells: involvement of large granular lymphocytes in the clearance of tumor cells in anti-asialo GM1-treated rats.

1983 • 166 citations

Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice

1980 • 165 citations

Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection.

1983 • 158 citations

Polymorphonuclear Leukocytes in Antibody-Dependent Cellular Cytotoxicity

1975 • 157 citations

Rapid In Vivo Assay of Mouse Natural Killer Cell Activity<xref ref-type="fn" rid="FN2">2</xref>

1979 • 154 citations

NATURAL KILLER CELLS IN THE MOUSE

1976 • 151 citations

Natural killer cell reactivity: regulatory interactions and among phorbol ester, interferon, cholera toxin, and retinoic acid.

1981 • 150 citations

Enhancement of tumor metastasis and suppression of natural killer cell activity by beta-estradiol treatment.

1983 • 147 citations

Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease

1982 • 145 citations

Evidence by reactivity with hybridoma antibodies for a probable myeloid origin of peripheral blood cells active in natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity.

1980 • 143 citations

Relationship Between Metastatic Potential and Resistance to Natural Killer Cellmediated Cytotoxicity in Three Murine Tumor Systems2, 3

1981 • 142 citations

Natural Killer Cells may be the Only Cells in Normal Mouse Lymphoid Cell Populations Endowed with Cytolytic Ability for Antibody‐Coated Tumour Target Cells

1978 • 140 citations

β-Estradiol Reduces Natural Killer Cells in Mice

1978 • 139 citations

Electron microscopic observations on formation of pulmonary metastases

1975 • 137 citations

Direct evidence that natural killer cells in nonimmune spleen cell populations prevent tumor growth in vivo

1979 • 136 citations

Natural killer activity in the rat. II. Analysis of surface antigens on LGL by flow cytometry.

1981 • 135 citations

Suppression of Natural Killer Cell Cytotoxicity by Splenocytes from Corynebacterium Parvum-Injected, Bone Marrow-Tolerant, and Infant Mice

1978 • 129 citations

Cloned lines of natural killer cells

1980 • 127 citations

Natural cytotoxic cells against solid tumors in mice. II. Some characteristics of the effector cells.

1978 • 126 citations

Role of nk cells in the antimetastatic effect of anticoagulant drugs

1984 • 126 citations

Death and Metastatic Distribution of Tumor Cells in Mice Monitored With <sup>125</sup>I-Iododeoxyuridine<xref ref-type="fn" rid="FN2">2</xref>

1969 • 122 citations

Role of Macrophages in the Augmentation of Mouse Natural Killer Cell Activity by Poly I:C and Interferon

1979 • 121 citations

The genetic control of natural killer cell activity and its association with in vivo resistance against a moloney lymphoma isograft

1976 • 120 citations

Morphological characterization of a cell population responsible for natural killer activity.

1981 • 120 citations

The Functions of the Macrophage in Malignant Disease

1976 • 119 citations

MALIGNANCY AND HAEMOSTASIS

1980 • 117 citations

Sequence of Events in Experimental Metastases of Walker 256 Tumor: Light, Immunofluorescent, and Electron microscopic Observations<xref ref-type="fn" rid="FN2">2</xref>

1971 • 116 citations

Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function.

1983 • 115 citations

Expression of metastatic potential of allogenic and xenogeneic neoplasms in young nude mice.

1981 • 109 citations

Identification and Separation of Thy-1 Positive Mouse Spleen Cells Active in Natural Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity

1979 • 106 citations

Differences in Resistance of Metastatic Tumor Cells and Cells From Local Tumor Growth to Cytotoxicity of Natural Killer Cells<xref ref-type="fn" rid="FN2">2</xref>

1979 • 101 citations

Depression of natural killer cytotoxicity after in vivo administration of recombinant leukocyte interferon.

1983 • 101 citations

Non‐T‐cell resistance against a mouse moloney lymphoma

1976 • 90 citations

Transfer to cyclophosphamide-treated mice of natural killer (NK) cells and in vivo natural reactivity against tumors.

1981 • 90 citations

Thymus, thymic hormones and T lymphocytes

1982 • 88 citations

ROLE OF INTERFERON IN REGULATION OF CYTOTOXICITY BY NATURAL KILLER CELLS AND MACROPHAGES

1980 • 86 citations

Malignancy and the Hemostatic System

1982 • 85 citations

Characteristics of human NK clones: target specificity and phenotype.

1984 • 84 citations

Studies of murine large granular lymphocytes. II. Tissue, strain, and age distributions of LGL and LAL.

1982 • 84 citations

Natural killer activity in the rat

1984 • 83 citations

Cultures of purified human natural killer cells: Growth in the presence of interleukin 2

1982 • 83 citations

Evidence that Natural Cytotoxicity and Antibody-Dependent Cellular Cytotoxicity Are Mediated in Humans by the Same Effector Cell Populations

1979 • 82 citations

Augmentation of metastasis formation by thioglycollate‐elicited macrophages

1982 • 72 citations

Immunogenetic Analysis of "Natural Killer" Activity in the Mouse

1979 • 66 citations

Natural cytotoxicity to human leukemia mediated by mouse non‐t cells

1977 • 66 citations

Delineation of an effector population responsible for natural killing and antibody-dependent cellular cytotoxicity in man

1981 • 65 citations

Immunoregulation and natural killer cells

1982 • 64 citations

Cytotoxic effector cells with the characteristics of natural killer cells in the lungs of mice

1980 • 61 citations

Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer

1980 • 61 citations

The mechanism of inhibition by Corynebacterium parvum of the growth of lung nodules from intravenously‐injected tumor cells

1974 • 56 citations

Human large granular lymphocytes: spontaneous and interferon-boosted NK activity against adherent and nonadherent tumor cell lines.

1981 • 55 citations

Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines.

1985 • 54 citations

Positive correlation between in vitro NK activity and in vivo resistance towards AKR lymphoma cells

1980 • 54 citations

Selection of 3LL tumor subline resistant to natural effector cells concomitantly selected for increased metastatic potency

1982 • 52 citations

Rejectability of virus-induced tumors and nonrejectability of spontaneous tumors: a lesson in contrasts.

1977 • 50 citations

Systemic andin situ natural killer and suppressor cell activities in mice bearing progressively growing murine sarcoma-virus-induced tumors

1981 • 49 citations

NATURAL CTOTOXIC (NC) CELLS AGAINST SOLID TUMORS IN MICE: GENERAL CHARACTERISTICS AND COMPARISON TO NATURAL KILLER (NK) CELLS11Supported by National Institute of Health Grants CA-08748, CA-15988 and CA-17818 and American Cancer Society Grant IM-188. Elizabeth Feo Figarella was supported by a grant from the “Consejo de Desarrollo Cientifico y Humanistico” and the “Centro Nacional de Referenda en Inmunologia Clinica” from the Universidad Central de Venezuela.

1980 • 46 citations

Inhibition of the activity of mouse natural killer cells by urethan.

1981 • 46 citations

The questionable immunogenicity of certain neoplasms

1977 • 45 citations

The effects of Corynebacterium parvum and surgery on the Lewis lung carcinoma and its metastases

1976 • 45 citations

Radioisotope assay for evaluation of in vivo natural cell‐mediated resistance of mice to local transplantation of tumor cells

1981 • 42 citations

Enhancement by cytotoxic agents of artificial pulmonary metastasis

1977 • 39 citations

Role of Immunosurveillance against Chemically Induced Rat Tumors

1976 • 35 citations

Resistance of tumor-bearing mice to a second tumor challenge.

1983 • 34 citations

Method for quantitating tumor cell removal and tumor cell-invasive capacity in experimental metastases.

1977 • 30 citations

Tumour cells in metastatic deposits with altered sensitivity to natural killer cells

1981 • 27 citations

AGE-INDEPENDENT NATURAL KILLER CELL ACTIVITY IN MURINE PERIPHERAL BLOOD

1982 • 23 citations

Host treatments affecting artificial pulmonary metastases: interpretation of loss of radioactively labelled cells from lungs

1979 • 21 citations

Modulation of formation of tumor metastases by peritoneal macrophages elicited by various agents

1985 • 21 citations

Human Cancer Immunology

1980 • 20 citations

Mediation of cellular immunity in cancer by immune modifiers

1981 • 15 citations

ARE NATURAL KILLER CELLS GERM-LINE V-GENE-ENCODED PROTHYMOCYTES SPECIFIC FOR SELF AND NONSELF HISTOCOMPATIBILITY ANTIGENS

1980 • 13 citations

HYPOTHESIS ON THE DEVELOPMENT OF NATURAL KILLER CELLS AND THEIR RELATIONSHIP TO T CELLS

1982 • 12 citations

ANTIGENIC PHENOTYPE OF MOUSE NATURAL KILLER CELLS11Supported in Part by Grants from NIH: CA-08748 CA-254 1 6, ACS:FRA-167, NSF and NATO

1980 • 11 citations

DIRECT EVIDENCE FOR ANTI-TUMOR ACTIVITY BY NK CELLS IN VIVO: GROWTH OF B16 MELANOMA IN ANTI-NK 1.1-TREATED MICE

1982 • 10 citations

The influence of a glucocorticoid on the lodgement and development in the lungs of intravenously injected tumour cells

1974 • 10 citations

Reduced susceptibility to natural killer cell lysis of hamster tumours exhibiting high levels of spontaneous metastasis

1983 • 10 citations

Differences in the metastatic potential of two sublines of tumor 3LL selected for resistance to natural NK-like effector cells

1983 • 9 citations

NATURAL CYTOTOXIC (NC) CELLS AGAINST SOLID TUMORS IN MICE: SOME TARGET CELL CHARACTERISTICS AND BLOCKING OF CYTOTOXICITY BY D-MANNOSE11Supported by National Institute of Health Grants CA-08748, CA-17818, and CA-15988 and American Cancer Society Grant IM-188.

1980 • 8 citations

THE ROLE OF GRANULOCYTES IN HOST DEFENSE AGAINST TUMORS

1980 • 8 citations

Variable susceptibility to NK activity of cloned cell lines derived from a primary rat rhabdomyosarcoma: Relationship to metastatic potential

1983 • 7 citations

Influence of adoptively transferred thioglycollate-elicited peritoneal macrophages on metastasis formation in mice with depressed or stimulated NK activity

1985 • 6 citations

NK CELL AND NAb ANTI-TUMOR ACTIVITY IN VIVO

1982 • 4 citations

Deleted Work

1955 • 0 citations