Chapter 24: The interaction of some centrally active drugs with the blood-brain barrier and circumventricular organs

Cardiovascular System

2000 • 2,962 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

1982 • 1,317 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

1977 • 710 citations

LOCALISATION OF ENDOCRINE-RELATED TUMOURS WITH RADIOIODINATED ANALOGUE OF SOMATOSTATIN

1989 • 607 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

1978 • 444 citations

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

1974 • 372 citations

BLOOD-BRAIN BARRIER

1943 • 356 citations

Multidrug Resistance1

1988 • 321 citations

Implications of the Blood-Brain Barrier and Its Manipulation

1989 • 308 citations

Quantitative aspects of reversible osmotic opening of the blood-brain barrier

1980 • 276 citations

Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood

1982 • 271 citations

Drug entry into the brain

1979 • 235 citations

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

1987 • 205 citations

Distribution and biochemical characterization of somatostatin receptors in tumors of the human central nervous system.

1987 • 151 citations

Structural and Functional Variations in Capillary Systems within the Braina

1988 • 150 citations

Permeability of the Blood‐Brain Barrier to the Immunosuppressive Cyclic Peptide Cyclosporin A

1990 • 128 citations

Pharmacokinetics of vincristine in the cerebrospinal fluid of humans.

1981 • 66 citations

Influence of blood components on the tissue uptake indices of cyclosporin in rats.

1988 • 59 citations

Effect of Dexamethasone on Transport of α‐Aminoisobutyric Acid and Sucrose Across the Blood‐Brain Barrier

1988 • 54 citations

Non-pituitary actions of somatostatin. A review on the therapeutic role of SMS 201-995 (sandostatin)

1986 • 47 citations

Distribution and metabolism of vincristine in mice, rats, dogs, and monkeys.

1977 • 46 citations

Vinca Alkaloids and Colchicine

1975 • 43 citations

Pharmacology of the Blood-Brain Barrier

1989 • 40 citations

Blood–Brain Glucose Transport in the Conscious Rat: Comparison of the Intravenous and Intracarotid Injection Methods

1980 • 39 citations

A guide to the clinical use of the somatostatin analogue SMS 201-995 (Sandostatin)

1987 • 31 citations

Somatostatin Receptors in Normal and Tumoral Tissue

1988 • 31 citations

The dependence of the blood to brain passage of radioactive sodium on blood pressure and temperature

1975 • 25 citations

Non-pituitary actions of hypothalamic hormones functional significance and therapeutic implications

1986 • 3 citations

Chemical Structure — Pharmacological Profile of Sandostatin®

1989 • 2 citations