Pharmacology of the Blood-Brain Barrier

Handbook of Physiology.

1960 • 10,428 citations

Partition coefficients and their uses

1971 • 4,444 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method

1963 • 1,138 citations

Measurement of local cerebral blood flow with iodo [14C] antipyrine

1978 • 927 citations

THE CEREBROSPINAL FLUID

1938 • 896 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Brain metabolism: a perspective from the blood-brain barrier

1983 • 745 citations

Insulin effects on monovalent cation transport and Na-K-ATPase activity

1978 • 692 citations

The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

1977 • 596 citations

An in situ brain perfusion technique to study cerebrovascular transport in the rat

1984 • 538 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

1978 • 444 citations

Transport of Protein-Bound Hormones into Tissuesin Vivo*

1981 • 435 citations

Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids

1973 • 424 citations

Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells

1980 • 389 citations

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

1974 • 372 citations

Blood-brain barrier in physiology and medicine

1977 • 364 citations

Transport of water and urea in red blood cells

1984 • 354 citations

High‐ and Low‐Affinity Transport of D‐Glucose from Blood to Brain

1981 • 325 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Application of 31P-NMR spectroscopy to the study of striated muscle metabolism

1982 • 306 citations

The localization of monoaminergic blood-brain barrier mechanisms.

1966 • 299 citations

Topics in Pharmaceutical Sciences

1982 • 264 citations

Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water

1976 • 262 citations

Separation of active and passive components of short-range stiffness of muscle

1977 • 247 citations

The Permeability of Brain Capillaries to Non‐Electrolytes

1965 • 246 citations

Drug entry into the brain

1979 • 235 citations

Topics in Pharmaceutical Sciences

1983 • 226 citations

Extracellular space of brain as determined by diffusion of inulin from the ventricular system

1962 • 221 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

SYNTHETIC AMINO ACIDS AND THE NATURE OF <scp>l</scp>‐DOPA TRANSPORT AT THE BLOOD‐BRAIN BARRIER

1975 • 210 citations

Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion

1975 • 207 citations

The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.

1973 • 205 citations

Sucrose and inulin space measurements of cerebral cortex in four mammalian species

1970 • 199 citations

Neuropeptides and the Blood-Brain Barrier

1983 • 192 citations

The Disposition of Propranolol

1972 • 188 citations

Rapid simultaneous determination of regional blood flow and blood‐brain glucose transfer in brain of rat¹

1980 • 177 citations

Blood-Brain and CSF Barriers to Penicillin and Related Organic Acids

1966 • 167 citations

KINETICS OF PENETRATION OF DRUGS AND OTHER FOREIGN COMPOUNDS INTO CEREBROSPINAL FLUID AND BRAIN

1959 • 159 citations

Structural Aspects of Brain Barriers, with Special Reference to the Permeability of the Cerebral Endothelium and Choroidal Epithelium

1980 • 158 citations

The nonelectrolyte permeability of planar lipid bilayer membranes.

1980 • 147 citations

Quantitative regional determination of morphometric indices of the total and perfused capillary network in the rat brain.

1982 • 143 citations

On the relative vascularity of various parts of the central nervous system of the albino rat

1920 • 138 citations

The Direct Demonstration of a Barrier Mechanism in the Brain Capillaries

1964 • 132 citations

Stability of the potassium content of cerebrospinal fluid and brain

1967 • 126 citations

Brain Uptake of Phenytoin, Phenobarbital, and Diazepam

1979 • 119 citations

Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults

1982 • 117 citations

Blood–Brain Barrier Transport of Valproic Acid

1985 • 108 citations

Enkephalin and Blood-Brain Barrier: Studies of Binding and Degradation in Isolated Brain Micro vessels*

1981 • 106 citations

The Antitumor Agent, 1,3-bis(2-chloroethyl)-1-nitrosourea

1966 • 106 citations

Distributed model for drug delivery to CSF and brain tissue

1983 • 105 citations

The influx of amino acids into the brain of the rat in vivo : the essential compared with some non-essential amino acids

1973 • 104 citations

Tryptophan transport through the blood-brain barrier: In vivo measurement of free and albumin-bound amino acid

1979 • 95 citations

Double-Tracer Study of the Fine Regional Blood—Brain Glucose Transfer in the Rat by Computer-Assisted Autoradiography

1985 • 94 citations

Entry of diazepam and its major metabolite into cerebrospinal fluid

1980 • 94 citations

Analysis of brain uptake and loss or radiotracers after intracarotid injection

1975 • 89 citations

Cerebral extraction of N-13 ammonia: its dependence on cerebral blood flow and capillary permeability -- surface area product.

1981 • 89 citations

The absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals.

1970 • 87 citations

Rat brain regional uptake and decarboxylation of L-DOPA following carotid injection

1975 • 86 citations

Blood—Brain Barrier Transport of Butanol and Water Relative to N-Isopropyl-p-Iodoamphetamine as the Internal Reference

1985 • 86 citations

Central Cardiovascular Control

1983 • 80 citations

Enzymes Related to Monoamine Transmitter Metabolism in Brain Microvessels

1980 • 75 citations

Ultrastructure of frog cerebral and pial microvessels and their impermeability to lanthanum ions

1982 • 74 citations

Evaluation of [¹²³I]Isopropyliodoamphetamine as a Tracer for Local Cerebral Blood Flow Using Direct Autoradiographic Comparison

1982 • 64 citations

Ionic lanthanum passage across cerebral endothelium exposed to hyperosmotic arabinose

1983 • 60 citations

Deoxynucleoside and vitamin transport into the central nervous system.

1984 • 59 citations

Characterization of the in vitro uptake of monoamines into brain microvessels

1980 • 57 citations

Amino acid supply to individual cerebral structures in awake and anesthetized rats

1982 • 54 citations

Blood-brain barrier transport and brain sequestration of propranolol and lidocaine

1984 • 49 citations

Saturable transport of amphetamine across the blood-brain barrier

1973 • 43 citations

A compartmental analysis of ²⁴Na kinetics in rat cerebrum, sciatic nerve and cerebrospinal fluid

1972 • 42 citations

Estimation of capillary permeability of inulin, sucrose and mannitol in rat brain cortex

1980 • 40 citations

Cerebrospinal fluid transport and the thiocyanate space of the brain

1966 • 38 citations

Uptake of [¹⁴C]urea by the in vivo choroid plexus—cerebrospinal fluid—brain system: identification of sites of molecular sieving

1978 • 38 citations

Studies on the enzymatic blood‐brain barrier: Quantitative measurements of DOPA decarboxylase in the wall of microvessels as related to the parenchyma in various CNS regions

1979 • 37 citations

Transfer across the human blood-brain barrier: Evidence for capillary recruitment and for a paradox glucose permeability increase in hypocapnia

1982 • 37 citations

Extent of plasma protein binding of amphetamine in different species

1972 • 37 citations

Carrier‐Mediated Transport of Chloride Across the Blood‐Brain Barrier

1984 • 37 citations

Distinctive histochemical characteristics of brain capillaries in organotypic culture

1976 • 31 citations

Increased Blood—Brain Barrier Transport of Protein-Bound Anticonvulsant Drugs in the Newborn

1983 • 30 citations

The absence of blood-brain barrier from certain areas of the central nervous system.

1961 • 29 citations

The dependence of the blood to brain passage of radioactive sodium on blood pressure and temperature

1975 • 25 citations

Uptake of Exogenous Aspartate into Circumventricular Organs but Not Other Regions of Adult Mouse Brain

1984 • 25 citations

Absorption of diazepam and its transfer through the blood-brain barrier after intraperitoneal administration in the rat.

1984 • 24 citations

Comparison of the Vascular Permeability of the Brain and the Spinal Cord to Mannitol and Inulin in Rats

1985 • 19 citations

The Blood-Brain Barrier and its Role in the Control of Circulating Hormone Effects on the Brain

1983 • 19 citations

Metabolism and Disposition of Baker's Antifolate (NSC-139105), Ftorafur (NSC-148958), and Dichlorallyl Lawsone (NSC-126771) in Man

1978 • 16 citations

CNS, CSF, and extradural fluid uptake of various hydrophilic materials in the dogfish

1977 • 16 citations

Kinetic studies on the entry of d-amphetamine into the central nervous system: I. Cerebrospinal fluid.

1980 • 5 citations