Development of an in vivo model of human multiple myeloma bone disease

Evidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma

1974 • 681 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

1990 • 493 citations

Effect of Phosphate, Calcium and Magnesium on Bone Resorption and Hormonal Responses in Tissue Culture

1969 • 410 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.

1995 • 260 citations

Identification of Committed Mononuclear Precursors for Osteoclast-Like Cells Formed in Long Term Human Marrow Cultures*

1990 • 232 citations

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

1992 • 201 citations

Production of interleukin-1 by bone marrow myeloma cells

1989 • 191 citations

Animal model of human disease. Multiple myeloma.

1988 • 183 citations

Cytokine Network in Human Multiple Myeloma

1992 • 150 citations

Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

1989 • 141 citations

Mechanisms of Bone Lesions in Multiple Myeloma

1992 • 116 citations

Stimulation of bone resorption in vitro by a non-prostanoid factor released by human monocytes in culture

1983 • 86 citations

Bone destruction and hypercalcemia in plasma cell myeloma.

1986 • 85 citations

Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease.

1993 • 76 citations

Importance of quantitative histology of bone changes in monoclonal gammopathy

1986 • 57 citations

Long-term engraftment of fresh human myeloma cells in SCID mice

1992 • 54 citations

Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage

1995 • 47 citations

The 5T2 mouse multiple myeloma model: characterization of 5T2 cells within the bone marrow

1987 • 38 citations

Current Issues in Cancer: Multiple myeloma

1994 • 30 citations

MOPC-315 Murine Plasmacytoma as a Model Anticancer Screen for Human Multiple Myeloma<xref ref-type="fn" rid="FN2">2</xref>

1986 • 11 citations